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Antizol

Generic Name: fomepizole (foe MEP i zole)
Brand Name: Antizol

Medically reviewed on April 23, 2018.

What is Antizol?

Antizol is an antidote to certain types of poison.

Antizol is used to treat poisoning with ethylene glycol (antifreeze) or methanol (contained in solvents, fuels, and other household or automotive chemicals). This medicine is sometimes used together with hemodialysis to rid the body of a poison.

Antizol may also be used for purposes not listed in this medication guide.

Important Information

In a poisoning situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received this medicine.

Before taking this medicine

If possible before you receive Antizol, tell your doctor if you have:

  • an allergy to any drug;

  • kidney disease or if you are unable to urinate; or

  • if you recently drank alcohol.

FDA pregnancy category C. It is not known whether Antizol will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether Antizol passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

In an emergency situation, it may not be possible before you are treated with Antizol to tell your caregivers if you are pregnant or breast-feeding. However, make sure any doctor caring for your pregnancy or your baby knows that you have received this medicine.

How is fomepizole given?

Antizol is injected into a vein through an IV. A healthcare provider will give you this injection.

You may be given other medicines and IV fluids as part of your treatment.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving Antizol. Your blood and urine will also need to be tested often during treatment, and your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

You will also be watched for any effects of the poisoning, such as problems with vision, breathing, or urination.

What happens if I miss a dose?

Because you will receive Antizol in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Antizol?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Antizol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness.

  • severe nausea, severe dizziness or spinning sensation; or

  • a light-headed feeling, like you might pass out.

Common side effects may include:

  • headache;

  • dizziness, drowsiness;

  • nausea; or

  • unpleasant or metallic taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Antizol?

Other drugs may interact with fomepizole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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