Drug Interactions between methotrexate and Synthroid
This report displays the potential drug interactions for the following 2 drugs:
- methotrexate
- Synthroid (levothyroxine)
Interactions between your drugs
No interactions were found between methotrexate and Synthroid. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
methotrexate
A total of 589 drugs are known to interact with methotrexate.
- Methotrexate is in the following drug classes: antimetabolites, antipsoriatics, antirheumatics, other immunosuppressants.
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Methotrexate is used to treat the following conditions:
- Acute Lymphoblastic Leukemia
- Acute Lymphocytic Leukemia
- Acute Nonlymphocytic Leukemia
- Bladder Cancer
- Brain Tumor
- Breast Cancer
- Bullous Pemphigoid
- Cervical Cancer
- Choriocarcinoma
- Cogan's Syndrome
- Colorectal Cancer
- Dermatomyositis
- Ectopic Pregnancy
- Eczema
- Esophageal Carcinoma
- Gastric Cancer
- Graft-versus-host disease
- Head and Neck Cancer
- Hodgkin's Lymphoma
- Juvenile Idiopathic Arthritis
- Lymphoma
- Mantle Cell Lymphoma
- Meningeal Leukemia
- Mycosis Fungoides
- Neoplastic Diseases
- Non-Hodgkin's Lymphoma
- Non-Small Cell Lung Cancer
- Osteosarcoma
- Ovarian Cancer
- Pancreatic Cancer
- Pemphigoid
- Pemphigus
- Pityriasis rubra pilaris
- Psoriasis
- Psoriatic Arthritis
- Rheumatoid Arthritis
- Scleroderma
- Small Cell Lung Cancer
- Soft Tissue Sarcoma
- Solid Tumors
- Systemic Sclerosis
- Trophoblastic Disease
- Uveitis
Synthroid
A total of 199 drugs are known to interact with Synthroid.
- Synthroid is in the drug class thyroid drugs.
- Synthroid is used to treat the following conditions:
Drug and food interactions
methotrexate food
Applies to: methotrexate
Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are receiving methotrexate for arthritis, you may want to limit your intake of caffeine-containing foods and medications. Check with your doctor or pharmacist if you have concerns or are uncertain what products may contain caffeine.
levothyroxine food
Applies to: Synthroid (levothyroxine)
The timing of meals relative to your levothyroxine dose can affect absorption of the medication. Therefore, levothyroxine should be taken on a consistent schedule with regard to time of day and relation to meals to avoid large fluctuations in blood levels, which may alter its effects. In addition, absorption of levothyroxine may be decreased by foods such as soybean flour, cotton seed meal, walnuts, dietary fiber, calcium, and calcium fortified juices. These foods should be avoided within several hours of dosing if possible. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
When levothyroxine is given during continuous enteral nutrition (tube feedings) for more than 7 days, the tube feeding should be interrupted for at least one hour before and one hour after the dose of levothyroxine. You may need more frequent blood tests to monitor levothyroxine levels.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See Also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
