Drug interactions between Flexeril and methotrexate
Interactions between your drugs
There were no interactions found in our database between Flexeril and methotrexate - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.
- Flexeril is in the drug class skeletal muscle relaxants.
- Flexeril is used to treat the following conditions:
- Methotrexate is a member of the following drug classes: antimetabolites, antipsoriatics, antirheumatics, other immunosuppressants.
- Methotrexate is used to treat the following conditions:
- Acute Lymphoblastic Leukemia
- Acute Lymphocytic Leukemia
- Acute Nonlymphocytic Leukemia
- Bladder Cancer
- Brain Tumor
- Breast Cancer
- Bullous Pemphigoid
- Cervical Cancer
- Cogan's Syndrome
- Colorectal Cancer
- Ectopic Pregnancy
- Esophageal Carcinoma
- Gastric Cancer
- Graft-versus-host disease
- Head and Neck Cancer
- Hodgkin's Lymphoma
- Juvenile Idiopathic Arthritis
- Mantle Cell Lymphoma
- Meningeal Leukemia
- Mycosis Fungoides
- Neoplastic Diseases
- Non-Hodgkin's Lymphoma
- Non-Small Cell Lung Cancer
- Ovarian Cancer
- Pancreatic Cancer
- Pityriasis rubra pilaris
- Psoriatic Arthritis
- Rheumatoid Arthritis
- Small Cell Lung Cancer
- Soft Tissue Sarcoma
- Solid Tumors
- Systemic Sclerosis
- Trophoblastic Disease
Drug and food interactions
Applies to: methotrexate
Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are receiving methotrexate for arthritis, you may want to limit your intake of caffeine-containing foods and medications. Check with your doctor or pharmacist if you have concerns or are uncertain what products may contain caffeine.
Applies to: Flexeril (cyclobenzaprine)
Alcohol can increase the nervous system side effects of cyclobenzaprine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cyclobenzaprine. Do not use more than the recommended dose of cyclobenzaprine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.