Skip to Content
Print Share

Medications for Muscle Spasm (Involuntary Hypertonicity)

Other names: Charley horse; Spasms

What is Muscle Spasm:  Painful involuntary muscle contractions. Often seen in skeletal muscle after acute injury

See also: sub-topics

Medications to treat Muscle Spasm

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Flexeril Rx B N X 102 reviews
6.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
cyclobenzaprine Rx B N X 242 reviews
6.0

Generic name: cyclobenzaprine systemic

Brand names:  Flexeril, Amrix, Comfort Pac with Cyclobenzaprine, Fexmid …

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
tizanidine Rx C N X 176 reviews
6.0

Generic name: tizanidine systemic

Brand name:  Zanaflex

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
baclofen Rx C N X 97 reviews
6.0

Generic name: baclofen systemic

Brand names:  Lioresal, Kemstro, Lioresal Intrathecal

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Soma Rx C 4 X 136 reviews
9.0

Generic name: carisoprodol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Zanaflex Rx C N X 76 reviews
7.0

Generic name: tizanidine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
methocarbamol Rx C N X 161 reviews
6.0

Generic name: methocarbamol systemic

Brand names:  Robaxin, Robaxin-750

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Valium Rx D 4 X 35 reviews
8.0

Generic name: diazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
diazepam Rx D 4 X 82 reviews
8.0

Generic name: diazepam systemic

Brand names:  Valium, Diastat, Diazepam Intensol, Diastat AcuDial, Diastat Pediatric …

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Robaxin Rx C N X 46 reviews
6.0

Generic name: methocarbamol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Skelaxin Rx N N X 56 reviews
7.0

Generic name: metaxalone systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
carisoprodol Rx C 4 X 175 reviews
8.0

Generic name: carisoprodol systemic

Brand names:  Soma, Vanadom

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Amrix Rx B N X 29 reviews
7.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Robaxin-750 Rx C N X 24 reviews
5.0

Generic name: methocarbamol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

 
Diastat Rx D 4 X 1 review
10

Generic name: diazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Diazepam Intensol Rx D 4 X 3 reviews
9.0

Generic name: diazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

 
Lioresal Rx C N X 7 reviews
7.0

Generic name: baclofen systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Norflex Rx C N X 14 reviews
6.0

Generic name: orphenadrine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
metaxalone Rx N N X 72 reviews
7.0

Generic name: metaxalone systemic

Brand names:  Skelaxin, Metaxall

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Comfort Pac with Cyclobenzaprine Rx B N X 2 reviews
4.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

 
chlorzoxazone Rx N N X 45 reviews
6.0

Generic name: chlorzoxazone systemic

Brand names:  Lorzone, Remular-S

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Fexmid Rx B N X 4 reviews
5.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Lorzone Rx N N X 20 reviews
6.0

Generic name: chlorzoxazone systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
orphenadrine Rx C N X 28 reviews
6.0

Generic name: orphenadrine systemic

Brand names:  Norflex, Antiflex, Orphenate, Mio-Rel, Orfro …

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Soma Compound Rx C 4 X 8 reviews
9.0

Generic name: aspirin / carisoprodol systemic

Drug class: skeletal muscle relaxant combinations

For consumers: dosage, interactions, side effects

 
Page 1 2 Next

Topics under Muscle Spasm

Alternative treatments for Muscle Spasm

The following products are considered to be alternative treatments or natural remedies for Muscle Spasm. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Muscle Spasm.

Learn more about Muscle Spasm (Involuntary Hypertonicity)

Drugs.com Health Center

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Browse Drugs by Condition

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Drugs.com Mobile Apps

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Explore Apps
Hide