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Medications for Muscle Spasm (Involuntary Hypertonicity)

Other names: Charley horse; Spasms

Painful involuntary muscle contractions. Often seen in skeletal muscle after acute injury

Drugs used to treat Muscle Spasm

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
cyclobenzaprine 5.7 349 reviews
Rx B N X

Generic name: cyclobenzaprine systemic

Brand names:  Amrix, Comfort Pac with Cyclobenzaprine, Fexmid

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

tizanidine 6.2 284 reviews
Rx C N X

Generic name: tizanidine systemic

Brand name:  Zanaflex

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

baclofen Off-label 6.1 150 reviews
Rx C N X

Generic name: baclofen systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

methocarbamol 5.9 226 reviews
Rx C N X

Generic name: methocarbamol systemic

Brand name:  Robaxin

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Soma 9.2 170 reviews
Rx C 4 X

Generic name: carisoprodol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Zanaflex 7.7 94 reviews
Rx C N X

Generic name: tizanidine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

diazepam 8.5 151 reviews
Rx D 4 X

Generic name: diazepam systemic

Brand names:  Valium, Diazepam Intensol

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Robaxin 6.2 62 reviews
Rx C N X

Generic name: methocarbamol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Valium 8.8 51 reviews
Rx D 4 X

Generic name: diazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

carisoprodol 9.1 251 reviews
Rx C 4 X

Generic name: carisoprodol systemic

Brand name:  Soma

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Skelaxin 7.7 66 reviews
Rx N N X

Generic name: metaxalone systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Amrix 6.9 32 reviews
Rx B N X

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Diazepam Intensol 9.8 4 reviews
Rx D 4 X

Generic name: diazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

metaxalone 7.2 96 reviews
Rx N N X

Generic name: metaxalone systemic

Brand names:  Skelaxin, Metaxall

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Comfort Pac with Cyclobenzaprine 4.5 2 reviews
Rx B N X

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

orphenadrine 6.9 52 reviews
Rx C N X

Generic name: orphenadrine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

chlorzoxazone 6.7 59 reviews
Rx N N X

Generic name: chlorzoxazone systemic

Brand name:  Lorzone

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Fexmid 5.8 4 reviews
Rx B N X

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Lorzone 6.0 21 reviews
Rx N N X

Generic name: chlorzoxazone systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

aspirin / caffeine / orphenadrine 7.0 10 reviews
Rx N N X

Generic name: aspirin / caffeine / orphenadrine systemic

Brand name:  Orphengesic Forte

Drug class: skeletal muscle relaxant combinations

For consumers: interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

aspirin / carisoprodol / codeine 9.3 3 reviews
Rx C 3 X

Generic name: aspirin / carisoprodol / codeine systemic

Drug class: skeletal muscle relaxant combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

Metaxall Rate Add review
Rx N N X

Generic name: metaxalone systemic

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

pentafluoropropane / tetrafluoroethane Rate Add review
OTC N N

Generic name: pentafluoropropane / tetrafluoroethane topical

Brand name:  Gebauer's Spray and Stretch

Drug class: topical anesthetics

For consumers: dosage, side effects

Gebauer's Spray and Stretch Rate Add review
OTC N N

Generic name: pentafluoropropane / tetrafluoroethane topical

Drug class: topical anesthetics

For consumers: dosage, side effects

Orphengesic Forte Rate Add review
Rx N N X

Generic name: aspirin / caffeine / orphenadrine systemic

Drug class: skeletal muscle relaxant combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Topics under Muscle Spasm

Alternative treatments for Muscle Spasm

The following products are considered to be alternative treatments or natural remedies for Muscle Spasm. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Muscle Spasm.

Learn more about Muscle Spasm (Involuntary Hypertonicity)

Drugs.com Health Center

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.