Other names: Cyclo-oxygenase-2 inhibitors
What are Cox-2 inhibitors
Cyclo-oxygenase-2 (COX-2) inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that specifically blocks COX-2 enzymes.
There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury. Prostaglandins have a number of different effects, one of which is to regulate inflammation.
By specifically only blocking COX-2 enzymes, COX-2 inhibitors relieve inflammation and pain with less adverse gastrointestinal effects than NSAIDs that inhibit both COX-1 and COX-2 enzymes. However, they are not devoid of gastrointestinal effects entirely, and their use (like all NSAIDs) has been associated with a higher risk of stroke and heart attack.
List of Cox-2 inhibitors:
|Drug Name||View by: Brand | Generic>||Reviews||Avg. Ratings|
|Bextra (Pro, More...)|
generic name: valdecoxib
generic name: rofecoxib
|Celebrex (Pro, More...)|
generic name: celecoxib