Leflunomide Interactions
There are 679 drugs known to interact with leflunomide, along with 7 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 548 are major, 121 are moderate, and 10 are minor.
- View all 679 medications that may interact with leflunomide
- View leflunomide alcohol/food interactions (2)
- View leflunomide disease interactions (7)
Most frequently checked interactions
View interaction reports for leflunomide and the medicines listed below.
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- Celebrex (celecoxib)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Enbrel (etanercept)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Humira (adalimumab)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- Orencia (abatacept)
- Ozempic (semaglutide)
- Plaquenil (hydroxychloroquine)
- ProAir HFA (albuterol)
- Protonix (pantoprazole)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zyrtec (cetirizine)
Leflunomide alcohol/food interactions
There are 2 alcohol/food interactions with leflunomide.
Leflunomide disease interactions
There are 7 disease interactions with leflunomide which include:
- immunosuppression
- liver disease
- peripheral neuropathy
- pulmonary toxicity
- renal dysfunction
- tuberculosis
- hypertension
Report options
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- Dosage information
- During pregnancy
- Drug class: antirheumatics
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
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Plaquenil
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Stelara
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Enbrel
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Remicade
Remicade is used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis and Crohn's ...
Rituxan
Rituxan infusion is used to treat certain leukemias and lymphomas and some non-cancer conditions ...
Orencia
Orencia is a type of biologic that is given by intravenous infusion or subcutaneous injection which ...
Infliximab
Infliximab infusion (brand names Avsola, Inflectra, Remicade, and others) reduces inflammation and ...
Rituximab
Rituximab infusion is used to treat certain leukemias and lymphomas and some non-cancer conditions ...
Adalimumab
Adalimumab is used to treat plaque psoriasis, Crohn's disease, ulcerative colitis, rheumatoid ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
