Leflunomide Alternatives Compared
Leflunomide | Upadacitinib | Methotrexate |
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Leflunomide | Upadacitinib | Methotrexate |
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Prescription only
Prescribed for Psoriatic Arthritis, Rheumatoid Arthritis. leflunomide may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Crohn's Disease, Ankylosing Spondylitis, Atopic Dermatitis, Non-Radiographic Axial Spondyloarthritis, Polyarticular Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Rheumatoid... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Related suggestions Rheumatoid Arthritis
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More about Leflunomide | More about Upadacitinib | More about Methotrexate | ||||||||||||||||
Ratings & Reviews | ||||||||||||||||||
Leflunomide has an average rating of 5.1 out of 10 from a total of 110 ratings on Drugs.com. 41% of reviewers reported a positive effect, while 46% reported a negative effect. |
Upadacitinib has an average rating of 6.7 out of 10 from a total of 175 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 24% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 332 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
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Drug Class | ||||||||||||||||||
Side Effects | ||||||||||||||||||
See also: leflunomide side effects in more detail. |
See also: upadacitinib side effects in more detail. |
See also: methotrexate side effects in more detail. |
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Generic Availability | ||||||||||||||||||
Lower cost generic |
N/A |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
View all leflunomide prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all methotrexate prices |
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Dosage Form(s) Available | ||||||||||||||||||
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N/A |
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Brand Names | ||||||||||||||||||
Arava | Rinvoq, Rinvoq LQ | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
336 hours |
14 hours |
15 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | ||||||||||||||||||
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||
A total of 655 drugs are known to interact with leflunomide:
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A total of 550 drugs are known to interact with upadacitinib:
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A total of 695 drugs are known to interact with methotrexate:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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Disease Interactions | ||||||||||||||||||
First Approval Date | ||||||||||||||||||
September 10, 1998 |
August 16, 2019 |
December 07, 1953 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||
Patient resources | ||||||||||||||||||
Professional Resources | ||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.