Leflunomide Alternatives Compared
| Leflunomide | Otezla (apremilast) | Stelara (ustekinumab) |
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| Leflunomide | Otezla (apremilast) | Stelara (ustekinumab) |
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Prescription only
Prescribed for Rheumatoid Arthritis, Psoriatic Arthritis. Leflunomide may also be used for purposes not listed in this medication guide. |
Prescription only
Otezla is a PDE4 inhibitor that may be used to treat adults with plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet’s Disease. It may also be used to treat plaque psoriasis... View more |
Prescription only
Stelara is an immunosuppressant medication that works by binding to two inflammatory cytokines, IL-12 and IL-23, which have been identified as important contributors to chronic inflammation. Stelara... View more |
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| More about Leflunomide | More about Otezla (apremilast) | More about Stelara (ustekinumab) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Leflunomide has an average rating of 5.1 out of 10 from a total of 115 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 46% reported a negative effect. |
Otezla has an average rating of 5.2 out of 10 from a total of 440 ratings on Drugs.com. 35% of reviewers reported a positive effect, while 40% reported a negative effect. |
Stelara has an average rating of 7.6 out of 10 from a total of 252 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 15% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Leflunomide side effects |
View all Otezla side effects |
View all Stelara side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Leflunomide prices |
View all Otezla prices |
View all Stelara prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Arava |
N/A |
Other ustekinumab brands include: Imuldosa, Otulfi, Pyzchiva, Selarsdi, Steqeyma, Wezlana, Yesintek | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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336 hours |
9 hours |
1291.2 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 680 drugs are known to interact with Leflunomide:
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A total of 110 drugs are known to interact with Otezla:
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A total of 537 drugs are known to interact with Stelara:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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September 10, 1998 |
March 21, 2014 |
September 25, 2009 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient Resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
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Plaquenil
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Stelara
Stelara (ustekinumab) is used to treat Crohn's disease, ulcerative colitis, plaque psoriasis, and ...
Enbrel
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Remicade
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Arava
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Rituxan
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Actemra
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Orencia
Orencia is a type of biologic that is given by intravenous infusion or subcutaneous injection which ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.