Leflunomide Drug Interactions
Currently displaying a list of 679 drugs known to interact with leflunomide.
- 548 major drug interactions
- 121 moderate drug interactions
- 10 minor drug interactions
Medications known to interact with leflunomide
Note: Showing generic names only.
A
- abacavir
- abatacept
- abemaciclib
- abiraterone
- abrocitinib
- acalabrutinib
- acarbose
- acetaminophen
- acetohexamide
- acitretin
- adagrasib
- adalimumab
- adenovirus vaccine
- ado-trastuzumab emtansine
- afamitresgene autoleucel
- afatinib
- aldesleukin
- alectinib
- alefacept
- alemtuzumab
- allogeneic processed thymus tissue
- allopurinol
- altretamine
- ambrisentan
- aminosalicylic acid
- amiodarone
- anakinra
- anifrolumab
- anisindione
- anthrax vaccine adsorbed
- anti-thymocyte globulin (rabbit)
- aprocitentan
- asciminib
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- aspirin
- atezolizumab
- atomoxetine
- atorvastatin
- atovaquone
- atrasentan
- auranofin
- aurothioglucose
- avacopan
- avapritinib
- axicabtagene ciloleucel
- axitinib
- azacitidine
- azathioprine
- azithromycin
B
- baricitinib
- basiliximab
- bcg
- bcg vaccine
- bedaquiline
- belantamab mafodotin
- belatacept
- belimumab
- belinostat
- belumosudil
- benazepril
- bendamustine
- benznidazole
- betamethasone
- bexarotene
- bicalutamide
- bifidobacterium infantis
- bifidobacterium longum
- bimekizumab
- binimetinib
- black cohosh
- bleomycin
- blinatumomab
- bortezomib
- bosentan
- bosutinib
- brentuximab
- brewer's yeast
- brexucabtagene autoleucel
- brigatinib
- brodalumab
- bromfenac
- budesonide
- bupropion
- busulfan
C
- cabazitaxel
- calaspargase pegol
- canakinumab
- candida albicans extract
- cannabidiol
- capecitabine
- capmatinib
- captopril
- carbamazepine
- carboplatin
- carfilzomib
- carmustine
- carvedilol
- caspofungin
- cat's claw
- celecoxib
- ceritinib
- cerivastatin
- certolizumab
- chaparral
- charcoal
- chenodiol
- chikungunya vaccine, live (cvx 317)
- chikungunya vaccine, recombinant (cvx 329)
- chlorambucil
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chloroquine
- chlorpropamide
- chlorzoxazone
- cholera vaccine
- cholera vaccine, live
- cholestyramine
- choline salicylate
- ciltacabtagene autoleucel
- cisplatin
- cladribine
- clarithromycin
- clavulanate
- clofarabine
- clotrimazole
- clozapine
- cobimetinib
- coccidioidin skin test
- colchicine
- comfrey
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- COVID-19 mRNA (Moderna) vaccine
- COVID-19 mRNA (Pfizer) vaccine
- crizotinib
- crovalimab
- cyclophosphamide
- cyclosporine
- cytarabine
D
- dacarbazine
- daclizumab
- dactinomycin
- danazol
- danicopan
- dantrolene
- daprodustat
- dapsone
- daratumumab
- darunavir
- dasatinib
- daunorubicin
- daunorubicin liposomal
- decitabine
- deferasirox
- deferiprone
- deflazacort
- dehydroepiandrosterone
- delandistrogene moxeparvovec
- dengue vaccine
- denileukin diftitox
- denosumab
- deucravacitinib
- dexamethasone
- diclofenac
- diclofenac topical
- dicumarol
- didanosine
- diflunisal
- dimethyl fumarate
- dinutuximab
- diroximel fumarate
- disulfiram
- divalproex sodium
- docetaxel
- dolutegravir
- doxorubicin
- doxorubicin liposomal
- dronedarone
- duloxetine
- dupilumab
- durvalumab
- duvelisib
E
- echinacea
- eculizumab
- efalizumab
- efavirenz
- efgartigimod alfa
- eflornithine
- elagolix
- elderberry
- elotuzumab
- elranatamab
- eltrombopag
- emtricitabine
- enalapril
- enalaprilat
- enfortumab vedotin
- ensifentrine
- entrectinib
- epcoritamab
- epirubicin
- eribulin
- erlotinib
- erythromycin
- etanercept
- ethambutol
- ethanol
- ethionamide
- ethotoin
- etodolac
- etoposide
- etranacogene dezaparvovec
- etrasimod
- etravirine
- etretinate
- everolimus
- ezetimibe
F
- fam-trastuzumab deruxtecan
- febuxostat
- fedratinib
- felbamate
- fenofibrate
- fenofibric acid
- fenoprofen
- fexinidazole
- fezolinetant
- fidanacogene elaparvovec
- fingolimod
- fitusiran
- floxuridine
- fluconazole
- fludarabine
- fludrocortisone
- fluorouracil
- fluoxymesterone
- flurbiprofen
- flutamide
- fluvastatin
- fosinopril
- fosphenytoin
- fostamatinib
- fruquintinib
G
- ganciclovir
- gefitinib
- gemcitabine
- gemtuzumab
- gilteritinib
- givinostat
- givosiran
- glimepiride
- glipizide
- glofitamab
- glyburide
- gold sodium thiomalate
- golimumab
- guselkumab
H
- haemophilus b conjugate (hboc) vaccine
- haemophilus b conjugate (prp-omp) vaccine
- haemophilus b conjugate (prp-t) vaccine
- hepatitis a adult vaccine
- hepatitis a pediatric vaccine
- hepatitis b adult vaccine
- hepatitis b pediatric vaccine
- histoplasmin
- human papillomavirus vaccine
- hydralazine
- hydrocortisone
- hydroxychloroquine
- hydroxyurea
I
- ibritumomab
- ibrutinib
- ibuprofen
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- imatinib
- imetelstat
- inavolisib
- indomethacin
- inebilizumab
- infliximab
- influenza virus vaccine, h1n1, inactivated
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, h5n1
- influenza virus vaccine, inactivated
- influenza virus vaccine, live
- inotersen
- inotuzumab ozogamicin
- interferon alfa-2a
- interferon alfa-2b
- interferon alfa-n1
- interferon alfacon-1
- interferon beta-1a
- interferon beta-1b
- interferon gamma-1b
- iobenguane I 131
- iodine i 131 tositumomab
- iodoquinol
- ipilimumab
- iptacopan
- irinotecan
- irinotecan liposomal
- isatuximab
- isoniazid
- isotretinoin
- itraconazole
- ivacaftor
- ixabepilone
- ixazomib
- ixekizumab
J
K
L
- labetalol
- lactobacillus acidophilus
- lactobacillus reuteri
- lactobacillus rhamnosus
- lactobacillus rhamnosus gg
- lamivudine
- lapatinib
- larotrectinib
- lenalidomide
- lenvatinib
- lesinurad
- levamisole
- levodopa
- levofloxacin
- levoketoconazole
- lifileucel
- linezolid
- lisinopril
- lisocabtagene maraleucel
- lomitapide
- lomustine
- lonafarnib
- loncastuximab tesirine
- losartan
- lovastatin
- lurbinectedin
- lutetium lu 177 dotatate
- lutetium lu 177 vipivotide tetraxetan
- lyme disease vaccine
- lymphocyte immune globulin, anti-thy (equine)
M
- macitentan
- magnesium salicylate
- maralixibat
- maraviroc
- measles virus vaccine
- mechlorethamine
- meclofenamate
- mefenamic acid
- meloxicam
- melphalan
- melphalan flufenamide
- meningococcal conjugate vaccine
- meningococcal group acwy conjugate-group b vaccine (cvx 316)
- meningococcal group B vaccine
- meningococcal polysaccharide vaccine
- mephenytoin
- mercaptopurine
- metaxalone
- methimazole
- methotrexate
- methyldopa
- methylprednisolone
- methyltestosterone
- metronidazole
- midostaurin
- milnacipran
- minocycline
- mipomersen
- mirikizumab
- mirvetuximab soravtansine
- mitomycin
- mitotane
- mitoxantrone
- mixed respiratory vaccine
- moexipril
- mogamulizumab
- momelotinib
- monomethyl fumarate
- montelukast
- mosunetuzumab
- moxifloxacin
- mumps skin test antigen
- mumps virus vaccine
- muromonab-cd3
- mycophenolate mofetil
- mycophenolic acid
N
- nabumetone
- nadofaragene firadenovec
- naltrexone
- nandrolone
- naproxen
- natalizumab
- nateglinide
- naxitamab
- nefazodone
- nelarabine
- nevirapine
- niacin
- niacinamide
- nicotinamide
- nilotinib
- nilutamide
- nintedanib
- niraparib
- nirogacestat
- nitrofurantoin
O
- obecabtagene autoleucel
- obinutuzumab
- ocrelizumab
- ofatumumab
- olaparib
- olaratumab
- olutasidenib
- omacetaxine
- onasemnogene abeparvovec
- orlistat
- osimertinib
- oxaliplatin
- oxandrolone
- oxaprozin
- oxymetholone
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- panobinostat
- pasireotide
- pazopanib
- pegaspargase
- pegcetacoplan
- peginterferon alfa-2a
- peginterferon alfa-2b
- peginterferon beta-1a
- pemetrexed
- pemoline
- penicillamine
- pennyroyal
- pentostatin
- perindopril
- pertussis, acellular
- pexidartinib
- phenazopyridine
- phenylbutazone
- phenytoin
- pioglitazone
- pirfenidone
- piroxicam
- pirtobrutinib
- pitavastatin
- plague vaccine
- plicamycin
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 23-polyvalent vaccine
- pneumococcal 7-valent vaccine
- polatuzumab vedotin
- poliovirus vaccine, inactivated
- poliovirus vaccine, live, trivalent
- pomalidomide
- ponatinib
- ponesimod
- posaconazole
- pozelimab
- pralatrexate
- pralsetinib
- pravastatin
- prednisolone
- prednisone
- procarbazine
- promazine
- propylthiouracil
- pyrazinamide
Q
R
- rabies vaccine, human diploid cell
- rabies vaccine, purified chick embryo cell
- radium 223 dichloride
- ramipril
- ravulizumab
- red yeast rice
- regorafenib
- remdesivir
- repotrectinib
- resmetirom
- revumenib
- ribociclib
- rifampin
- rilonacept
- rilpivirine
- riluzole
- risankizumab
- ritlecitinib
- ritonavir
- rituximab
- rofecoxib
- roflumilast
- romidepsin
- ropeginterferon alfa-2b
- rosiglitazone
- rosuvastatin
- rotavirus vaccine
- rozanolixizumab
- rsv vaccine pref3, recombinant
- rsv vaccine, mrna
- rsv vaccine, pref a-pref b, recombinant
- rubella virus vaccine
- rucaparib
- ruxolitinib
- ruxolitinib topical
S
- saccharomyces boulardii lyo
- sacituzumab govitecan
- salsalate
- sarilumab
- sars-cov-2 (covid-19) ad26 vaccine, recombinant
- sars-cov-2 (covid-19) chadox1 vaccine, recombinant
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)
- sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant
- sars-cov-2 (covid-19) rs-nanoparticle vaccine, recombinant
- sars-cov-2 mrna (tozinameran 5y-11y) vaccine
- sars-cov-2 mrna (tozinameran 6m-4y) vaccine
- sars-cov-2 mrna (tozinameran-tris-sucrose) vaccine
- sars-cov-2 mrna (tozinameran) vaccine
- sars-cov-2 mrna-1273 (6m-5y) vaccine
- sars-cov-2 mrna-1273 (6y-11y) vaccine
- sars-cov-2 mrna-1273 (booster only) vaccine
- sars-cov-2 nvx-cov2373 vaccine, recomb (cvx 313)
- sars-cov-2 pres dtm (booster only) vaccine, recombinant
- satralizumab
- secnidazole
- secukinumab
- seladelpar
- selinexor
- selpercatinib
- siltuximab
- simvastatin
- siponimod
- sipuleucel-T
- sirolimus
- sirolimus protein-bound
- skin test antigens, multiple
- smallpox and mpox vaccine
- smallpox vaccine
- sodium salicylate
- sodium thiosalicylate
- sorafenib
- sotorasib
- sparsentan
- spesolimab
- stanozolol
- staphage lysate (spl)
- stavudine
- streptococcus salivarius
- streptozocin
- sulfasalazine
- sulindac
- sunitinib
- sutimlimab
T
- tacrine
- tacrolimus
- tafasitamab
- tagraxofusp
- talazoparib
- talimogene laherparepvec
- talquetamab
- tamoxifen
- tarlatamab
- teclistamab
- telbivudine
- telithromycin
- temozolomide
- temsirolimus
- teniposide
- tenofovir alafenamide
- tenofovir disoproxil
- teplizumab
- tepotinib
- terbinafine
- teriflunomide
- testosterone
- testosterone topical
- tetanus toxoid
- thalidomide
- thioguanine
- thiotepa
- tick-borne encephalitis (inactivated) pediatric vaccine
- tick-borne encephalitis (inactivated) vaccine
- tildrakizumab
- tinidazole
- tipranavir
- tisagenlecleucel
- tisotumab vedotin
- tizanidine
- tocilizumab
- tofacitinib
- tolazamide
- tolbutamide
- tolcapone
- tolmetin
- tolvaptan
- topotecan
- torsemide
- tositumomab
- tovorafenib
- trabectedin
- trandolapril
- trastuzumab
- treosulfan
- tretinoin
- triamcinolone
- triamcinolone ophthalmic
- trichophyton skin test
- trimetrexate
- troglitazone
- troleandomycin
- trovafloxacin
- tuberculin purified protein derivative
- tucatinib
- typhoid vaccine, inactivated
- typhoid vaccine, live
U
V
- vadadustat
- valdecoxib
- valganciclovir
- valoctocogene roxaparvovec
- valproic acid
- vamorolone
- vardenafil
- varicella virus vaccine
- vedolizumab
- vemurafenib
- venetoclax
- vilobelimab
- vimseltinib
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- vitamin e
- voclosporin
- vorasidenib
- voriconazole
W
Y
Z
- zafirlukast
- zalcitabine
- zanubrutinib
- zidovudine
- zileuton
- zilucoplan
- zinc acetate
- zinc chloride
- zinc gluconate
- zinc sulfate
- ziv-aflibercept
- zolbetuximab
- zoster vaccine live
- zoster vaccine, recombinant
Leflunomide alcohol/food interactions
There are 2 alcohol/food interactions with leflunomide.
Leflunomide disease interactions
There are 7 disease interactions with leflunomide which include:
- immunosuppression
- liver disease
- peripheral neuropathy
- pulmonary toxicity
- renal dysfunction
- tuberculosis
- hypertension
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More about leflunomide
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
