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Diclofenac Dosage

Medically reviewed by Drugs.com. Last updated on May 5, 2022.

Applies to the following strengths: sodium 25 mg; potassium 50 mg; sodium 75 mg; sodium 100 mg; sodium 50 mg; 37.5 mg/mL; potassium 25 mg; sodium; 18 mg; 35 mg

Usual Adult Dose for Osteoarthritis

Diclofenac free acid capsules: 35 mg orally 3 times a day
Diclofenac potassium immediate-release tablets: 50 mg orally 2 or 3 times a day
Diclofenac sodium enteric-coated tablets: 50 mg orally 2 or 3 times a day or 75 mg orally 2 times a day
Maximum dose: 150 mg daily

Diclofenac sodium extended-release tablets: 100 mg orally once a day

Use: For the relief of signs and symptoms of osteoarthritis.

Usual Adult Dose for Ankylosing Spondylitis

Diclofenac sodium enteric-coated and delayed-release tablets: 25 mg orally 4 times a day. An additional 25 mg dose may be administered at bedtime, if necessary
Maximum dose: 125 mg per day

Use: For acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis.

Usual Adult Dose for Dysmenorrhea

Diclofenac potassium immediate-release tablets: 50 mg orally 3 times a day

Comments: An initial dose of 100 mg orally followed by 50 mg oral doses may provide better relief for some patients; initiate treatment upon appearance of the first symptoms and continue for a few days.

Use: For the relief of signs and symptoms of primary dysmenorrhea.

Usual Adult Dose for Rheumatoid Arthritis

Diclofenac potassium immediate-release tablets: 50 mg orally 3 or 4 times a day
Diclofenac sodium enteric-coated and delayed-release tablets: 50 mg orally 3 to 4 times a day or 75 mg orally twice a day
Maximum dose: 225 mg daily

Diclofenac sodium extended-release tablets: 100 mg orally once a day
Maximum dose: 100 mg orally 2 times a day; this would be for the rare patient in whom the benefits outweigh the clinical risks.

For the relief of signs and symptoms of rheumatoid arthritis

Usual Adult Dose for Migraine

Diclofenac potassium for oral solution packets: 50 mg (1 packet) orally once

Comments: This drug is not indicated for the prophylactic therapy of migraine or for use in cluster headaches; the safety and efficacy of a second dose has not been established.

Use: For acute treatment of migraine with or without aura.

Usual Adult Dose for Pain

Oral:
Diclofenac potassium liquid-filled capsules: 25 mg orally 4 times a day
Diclofenac free acid capsules: 18 mg or 35 mg orally 3 times a day
Diclofenac potassium immediate-release tablets: 50 mg orally 3 times a day; an initial dose of 100 mg orally followed by 50 mg oral doses may provide better relief in some patients.

Comment: Neither the diclofenac potassium liquid filled capsules nor the diclofenac free acid capsules are interchangeable with each other or with other diclofenac products containing the sodium or potassium salt.

Parenteral:
37.5 mg IV bolus over 15 seconds every 6 hours as needed for pain
Maximum Dose: 150 mg per day

Comment: Patients should be well hydrated prior to IV administration of this drug in order to reduce the risk of adverse renal reactions.

Uses: For the management of mild to moderate acute pain (oral, IV) and moderate to severe pain alone or in combination with opioid analgesics (IV).

Usual Pediatric Dose for Pain

Diclofenac potassium liquid-filled capsules:
12 years and older: 25 mg orally four times a day

Comments:


Use: Mild to moderate acute pain

Renal Dose Adjustments

Oral:
Use with caution in patients with advanced renal disease; if treatment is initiated, close monitoring of renal function is recommended.

Parenteral:
Moderate to severe renal insufficiency in the perioperative period and at risk for volume depletion: Use is contraindicated
Moderate to severe renal impairment: Use is not recommended

Liver Dose Adjustments

Oral:
Use with caution; patients with hepatic disease may require reduced doses; start at the lowest dose, if efficacy is not achieved, consider drug discontinuation.

Parenteral:
Mild hepatic impairment: No dosage adjustment recommended
Moderate to severe hepatic impairment: Use is not recommended

Dose Adjustments

Precautions

US BOXED WARNINGS: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS:


CONTRAINDICATIONS:
Additional AU and UK Contraindications:

Product specific Contraindications:
PARENTERAL USE:
Additional UK Contraindications
SUPPOSITORY:

Safety and efficacy have not been established in patients younger than 12 years (oral liquid filled capsules) to 18 years (other formulations).

Consult WARNINGS section for additional precautions.

Dialysis

Diclofenac is not expected to be removed by dialysis due to its high degree of protein binding.

Other Comments

Administration advice:
Oral:

Parenteral:

Storage:
Injection for IV use: Protect from light; Do not freeze; Store at controlled room temperature 20C to 25C (68F to 77F)

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.