Diclofenac Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Diclofenac	Ubrelvy (ubrogepant)	Nurtec ODT (rimegepant)	Enter another drug to compare

Diclofenac

Ubrelvy (ubrogepant)

Nurtec ODT (rimegepant)

Prescription only

Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects compared with some other NSAIDs. Prescribed... View more

Prescription only

Ubrelvy is a prescription medicine that may be used to treat acute migraine attacks in adults and works by blocking the effects of a protein, called CGRP that is thought to play a role in migraine... View more

Prescription only

Nurtec ODT may be placed onto or under the tongue to treat the symptoms of migraine in adults, and it may also be used to prevent episodic migraine when taken every second day. Nurtec ODT works by... View more

More about Diclofenac

More about Ubrelvy (ubrogepant)

More about Nurtec ODT (rimegepant)

Ratings & Reviews

Diclofenac has an average rating of 7.3 out of 10 from a total of 701 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 21% reported a negative effect.

Ubrelvy has an average rating of 6.5 out of 10 from a total of 275 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 34% reported a negative effect.

Nurtec ODT has an average rating of 6.5 out of 10 from a total of 335 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 29% reported a negative effect.

View all 701 reviews

View all 275 reviews

View all 335 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Upset stomach (4.9%)
Diarrhea (3.3%)
Nausea (3.3%)
Dizziness (2.9%)
Stomach pain (2.1%)
Drowsiness (2.0%)
Headaches (1.7%)

View all Diclofenac side effects

Nausea (17.5%)
Dizziness (6.9%)
Tiredness (6.9%)
Drowsiness (5.5%)
Vomiting (5.1%)
Headaches (4.7%)
Sleepy (4.0%)

View all Ubrelvy side effects

Nausea (18.8%)
Dizziness (4.5%)
Headaches (3.9%)
Tiredness (3.9%)
Migraine (3.3%)
Upset stomach (3.0%)
Vomiting (3.0%)

View all Nurtec ODT side effects

Drug Class

Nonsteroidal anti-inflammatory drugs

CGRP inhibitors

CGRP inhibitors

Generic Availability

Lower cost generic

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	10 delayed release tablet
Strength	sodium 75 mg
Per unit^*	$0.92
Cost^*	$9.17

View all Diclofenac prices

Quantity	10 tablet
Strength	100 mg
Per unit^*	$110.05
Cost^*	$1,100.54

View all Ubrelvy prices

Quantity	8 tablet, disintegrating
Strength	75 mg
Per unit^*	$126.63
Cost^*	$1,013.02

View all Nurtec ODT prices

Get free Discount Card

Dosage Forms

Oral capsule
Oral delayed release tablet
Oral powder for reconstitution
Oral tablet
Oral tablet, extended release

Oral tablet

Oral tablet, disintegrating

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

1.8 hours

7 hours

11 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 452 drugs are known to interact with Diclofenac:

100 major drug interactions (422 brand and generic names)
335 moderate drug interactions (1311 brand and generic names)
17 minor drug interactions (83 brand and generic names)

A total of 248 drugs are known to interact with Ubrelvy:

38 major drug interactions (96 brand and generic names)
209 moderate drug interactions (601 brand and generic names)
1 minor drug interactions (2 brand and generic names)

A total of 171 drugs are known to interact with Nurtec ODT:

57 major drug interactions (174 brand and generic names)
113 moderate drug interactions (320 brand and generic names)
1 minor drug interactions (2 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using diclofenac together with alcohol. Do not drink alcohol while taking... View more

Grapefruit and grapefruit juice can increase the blood levels of ubrogepant. This may increase... View more

If you are receiving therapy with rimegepant you may want to avoid the regular consumption of large... View more

Disease Interactions

First Approval Date

July 28, 1988

December 23, 2019

February 27, 2020

WADA Class View classifications

N/A

More Information

Patient Resources

Ubrelvy uses

Nurtec ODT uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Diclofenac Alternatives Compared

See also:

Ubrelvy

Nurtec ODT

Qulipta

Cosentyx

Humira

Taltz

Paracetamol

Naproxen

Oxycodone

Cyclobenzaprine

Further information

Diclofenac Alternatives Compared

See also:

Further information

Compare Drugs