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Nurtec ODT Disease Interactions

There are 2 disease interactions with Nurtec ODT (rimegepant).

Major

Rimegepant (applies to Nurtec ODT) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Rimegepant should be avoided in patients with ESRD as it not been studied in patients with CrCl less than 15 mL/min or among patients on dialysis. No dosage adjustment is necessary for patients with mild to severe renal impairment. A single-dose pharmacokinetic study showed exposure to rimegepant in patients with mild or severe renal impairment was not clinically meaningful different compared to normal subjects, however, exposure in subjects with moderate renal impairment was approximately 40% higher. In healthy male subjects, 78% of a radiolabeled dose was excreted in the feces and 24% in the urine.

References

  1. "Product Information. Nurtec ODT (rimegepant)." Biohaven Pharmaceuticals (2020):
Major

Rimegepant (applies to Nurtec ODT) severe hepatic impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Rimegepant should be avoided in patients with severe hepatic impairment. A dedicated pharmacokinetic study has shown an approximately 2-fold increased exposure to a single-dose of rimegepant in patients with severe hepatic impairment (Child-Pugh class C). There were no clinically meaningful differences in rimegepant exposure with mild (Child-Pugh class A) and moderate hepatic impairment (Child-Pugh class B).

References

  1. "Product Information. Nurtec ODT (rimegepant)." Biohaven Pharmaceuticals (2020):

Nurtec ODT drug interactions

There are 152 drug interactions with Nurtec ODT (rimegepant).

Nurtec ODT alcohol/food interactions

There is 1 alcohol/food interaction with Nurtec ODT (rimegepant).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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