Comparing Acetaminophen vs Diclofenac
| Acetaminophen Remove Acetaminophen from your drug comparison | Diclofenac Remove Diclofenac from your drug comparison |
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| Acetaminophen Remove Acetaminophen from your drug comparison | Diclofenac Remove Diclofenac from your drug comparison | ||||||||||||||||
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Acetaminophen is an effective mild pain reliever with a low risk of side effects. Prescribed for Sciatica, Muscle Pain, Pain, Fever, Eustachian Tube Dysfunction, Chiari Malformation, Neck Pain,... View more |
Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects. Prescribed for Back Pain, Frozen Shoulder,... View more |
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Prescription and OTC |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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6.7
For Fever: Had high fever, took 2 Tylenol extra strength and fever broke within 1/2 hour. You'll sweat a lot as fever breaks but that's normal per my doctor. |
7.6
For Pain: Diclofenac takes the edge of my hip pain. For Pain: Gained a greater range of motion after rotator cuff surgery. |
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Drug Class |
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Side Effects |
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See the full acetaminophen side effects document. |
See the full diclofenac side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all acetaminophen prices |
View all diclofenac prices |
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Generic Availability |
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Yes (this medicine) |
Yes (this medicine) |
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Dosage Form(s) Available |
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Brand Names |
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| 7T Gummy ES Chewable Tablets, Abenol, Acephen, Actamin, Actimol Children's, Actimol Infant, Adprin B, Aldi Hedanol Paracetamol, Alpha First Aid Supplies Paracetamol, Alphapharm Paracetamol, Altenol, Alvedon, Amadol Paracetamol, Amcal Childrens Paracetamol 1-5 Years, Amcal Childrens Paracetamol 5-12 Years, Amcal Paracetamol Infant Drops 1 Month to 2 Years, Amcal Paracetamol Pain Relief, Amcal Paracetamol Tabsules, Aminofen, Anacin Aspirin Free, Anadin Paracetamol, API Healthcare Coloufree Childrens Paracetamol, API Healthcare Colourfree Childrens Paracetamol Double Strength, API Healthcare Paracetamol, Apra, Arthritis Pain Relief, Atasol, Atasol Forte, Aurophen, BF-Paradac, Bi-Lo Paracetamol, Biochemie Paracetamol, Blooms the Chemist Paracetamol, Bristol Pharma Paracetamol, Buckley's Complete, Bydol, Calpol Fastmelts, Calpol Infant, Calpol Paediatric, Calpol Six Plus, Capital Chemist Paracetamol, Cetafen, Cetafen Extra, Chem Mart Chemadol, Chem Mart Chemadol Children 1 to 5 Years, Chem Mart Chemadol Colourfree, Chem Mart Chemadol Colourfree Children 5-12 Years, Chem Mart Chemadol Colourfree Childrens 1-5 Years, Chemists Own Chiildrens Paracetamol 5-12 Years, Chemists Own Childrens Paracetamol 1-5 Years, Chemists Own Paracetamol, Chemists Own Paracetamol Capseals, Chemists Own Paracetamol Pain & Fever 1 Month to 2 Years, Chemists Own Paracetamol Pain & Fever 1 to 5 Years, Chemists Own Paracetamol Pain and Fever 5 to 12 Years, Chemplus Paracetamol, Chemworld Colourfree Childrens Paracetamol Double Strength 5-12 Years, Chemworld Colourfree Childrens Paracetamol Junior 1-5 Years, Chemworld Paracetamol, Chemworld Paracetamol Infant Colour Free, Children's ElixSure, Children's Silapap, Children's Tylenol, Childrens Panadol 1 - 5 Years, Childrens Panadol 1 - 5 Years Colourfree, Childrens Panadol 5 - 12 Years, Childrens Panadol 5 - 12 Years Colourfree, Cipla Genpharm Paracetamol, Claradol, Coles Paracetamol, Conacetol, Conney Aspirin-Free, ConRx Extra Strength, Country Chemists Paracetamol, Cuprofen for Children, Dafalgan, Dakota Paracetamol, DG Health Pain Reliever, Disprol Paracetamol, Disprol Soluble Paracetamol, Doliprane, Doliprane Adultes, Doliprane Sans Sucre, Dolitabs, Dolko, Dolko Enfants, Dolono, Dolono Infant, Dolotec, Duatrol SR, Dymadon, Ed-APAP, Efferalgan, Efferalgan Pediatrique, Efferalganodis, Elixsure Fever/Pain, Equaline Pain Relief, Expandox, Fawns & McAllan Paracetamol, Febridol, Febridol Clear Effervescent, Febridol Infant Drops, Febridol Syrup for Children, Febrol Solution, Fennings Childrens Cooling, Feverall, Flu Strength Hot Lemon Powders, Galpamol, Geluprane, Genapap, Genapap Extra Strength, Genebs, Gold Cross Paracetamol, Guardian Childrens Paracetamol, Guardian Childrens Paracetamol 5-12 Years, Guardian Paracetamol, Guardian Paracetamol Tabsules, Help I Have A Headache, Home Brand Paracetamol, HyVee Health 8 Hour Pain Relief, Infant's Tylenol, Infantaire Drops, Jr. Tylenol, Leader 8 Hour Pain Reliever, Lemsip Childrens Cold & Flu, Lemsip Cold and Flu Liquid Capsule, Lemsip Headcold, Lemsip Max, Lemsip Original, Lemsip Pharmacy Non-Decongestant Formula, M-Pap, Mapap, Mapap Arthritis Pain, Mapap Extra Strength Rapid Burst, Mapap Rapid Release Gelcaps, Mapap Rapid Tabs, Masophen, Midol Long Lasting Relief, Nortemp Children's, Ofirmev, Orajel Maximum Strength Toothache, Panadol, Panadol ActiFast, Panadol Childrens, Panadol Colourfree Drops, Panadol Extend, Panadol Gel Caps, Panadol Gel Tabs, Panadol Jr, Panadol Mini Caps, Panadol Osteo, Panadol Rapid Handipak, Panadol Soluble, Panamax, Panamax 240, Panamol, Paracetamol, PediaCare Children's Acetaminophen Fever Reducer/Pain Reliever, PediaCare Infants' Acetaminophen Fever Reducer/Pain Reliever, PediaCare Smooth Melts Acetaminophen Fever Reducer/Pain Reliever, Pharbetol, Silapap Childrens, Tactinal, Tempra Quicklets, Topcare 8 Hour Pain Relief, Topcare Arthritis Pain Relief, Triaminic Fever Reducer Pain Reliever, Triaminic Infant Drops, Tycolene, Tylenol, Tylenol 8 Hour, Tylenol Arthritis Pain, Tylenol Childrens Paracetamol, Tylenol Cold Sore Throat, Tylenol Cool Caplet Extra Strength, Tylenol Extra Strength, Tylenol Regular Strength, Tylenol Sore Throat Daytime, Tylophen, UN-Aspirin Extra Strength, Valorin, Vicks Formula 44 Custom Care Body Aches, Vitapap, Zee Unaspirin ES View more | Cambia, Cataflam, Voltaren, Zipsor, Zorvolex | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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2.5 hours |
1.8 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category D
Positive evidence of risk
See the full Pregnancy Warnings document. |
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FDA Alerts |
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Drug Interactions |
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A total of 116 drugs are known to interact with acetaminophen:
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A total of 383 drugs are known to interact with diclofenac:
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Alcohol/Food/Lifestyle Interactions |
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Disease Interactions |
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First Approval Date |
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November 07, 1968 |
July 28, 1988 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Fever: My son has had a lo-grade fever for three days. I've had him on Tylenol every 4 hours but decided to try Motrin instead during his regular dosing schedule. It didn't do a thing. His fever kept rising. Tylenol is the only thing that has worked for him.