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Cambia

Generic Name: diclofenac (dye KLOE fen ak)
Brand Names: Cambia, Zipsor, Zorvolex

Medically reviewed by Sanjai Sinha, MD. Last updated on Apr 19, 2020.

What is Cambia?

Cambia (diclofenac) is a nonsteroidal anti-inflammatory drug (NSAID). Diclofenac works by reducing substances in the body that cause pain and inflammation.

Cambia oral powder is used to treat a migraine headache attacks, with or without aura, in adults 18 years of age and older. It is not used to prevent migraine headaches. Do not use Cambia to treat a cluster headache.

Cambia will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Important information

You should not use Cambia if you have a history of allergic reaction to aspirin or NSAIDs (non-steroidal anti-inflammatory drugs).

Diclofenac can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Cambia may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Cambia, especially in older adults.

Before taking this medicine

Cambia may cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Cambia, especially in older adults.

Diclofenac can also increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

You should not use Cambia if you are allergic to diclofenac, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Do not use Cambia to treat a cluster headache.

To make sure this medicine is safe for you, tell your doctor if you have:

  • heart disease, high blood pressure;

  • ulcers or bleeding in your stomach;

  • asthma;

  • liver or kidney disease; or

  • if you smoke.

Taking diclofenac during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Cambia is not approved for use by anyone younger than 18 years old.

How should I take Cambia?

Take Cambia oral powder exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Take one dose of Cambia to treat your migraine headache:

  • remove one single dose packet from a set of three packets
  • open the packet only when you are ready to use it
  • empty contents of packet into 1 to 2 ounces or 2 to 4 tablespoons (30 to 60 mL) of water. Do not use any other form of liquid
  • mix well and drink the water and powder mixture
  • throw away empty packet in a safe place and out of the reach of children
  • taking Cambia with food may cause a reduction in effectiveness compared to taking Cambia on an empty stomach.

Call your doctor if your headache does not completely go away after taking Cambia. Do not take a second dose without your doctor's advice. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks

If you use Cambia long-term, you may need frequent medical tests.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Cambia dosing information

Usual Adult Dose for Migraine:

Diclofenac potassium for oral solution packets: 50 mg (1 packet) orally once

Comments: This drug is not indicated for the prophylactic therapy of migraine or for use in cluster headaches; the safety and efficacy of a second dose has not been established.

Use: For acute treatment of migraine with or without aura.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Cambia?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin or other NSAIDs unless your doctor tells you to.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to diclofenac (such as aspirin, ibuprofen, ketoprofen, or naproxen).

Cambia side effects

Get emergency medical help if you have signs of an allergic reaction to Cambia (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using Cambia and call your doctor at once if you have:

  • the first sign of any skin rash, no matter how mild;

  • flu-like symptoms;

  • heart problems - swelling, rapid weight gain, feeling short of breath;

  • kidney problems - little or no urinating, painful or difficult urination, swelling in your arms or legs, feeling tired or short of breath;

  • liver problems - nausea, diarrhea, stomach pain (upper right side), tiredness, itching, dark urine, jaundice (yellowing of the skin or eyes); or

  • signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common Cambia side effects may include:

  • indigestion, gas, nausea, vomiting, stomach pain;

  • diarrhea, constipation;

  • headache, dizziness, drowsiness;

  • abnormal lab tests;

  • itching, sweating;

  • stuffy nose;

  • increased blood pressure; or

  • swelling or pain in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Cambia?

Ask your doctor before using Cambia if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with diclofenac, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cambia only for the indication prescribed..

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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