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Acetaminophen Drug Interactions

A total of 181 drugs are known to interact with acetaminophen.

  • 14 major drug interactions
  • 73 moderate drug interactions
  • 94 minor drug interactions

Show all medications in the database that may interact with acetaminophen.

Check for interactions with acetaminophen

Type in a drug name and select a drug from the list.

Common medications checked in combination with acetaminophen

  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Bufferin, Ecotrin Adult Low Strength, Arthritis Pain, Fasprin, Halfprin, Aspiritab, Easprin, Aspergum, Durlaza, St. Joseph 81 mg Chewable Aspirin, Empirin, Buffered Aspirin, Ecotrin Maximum Strength, Ascriptin Enteric, Migralex, Aspi-Cor, Aspirtab, Low Dose ASA, Bufferin Extra Strength, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Bayer Children's Aspirin, Bayer Aspirin Extra Strength Plus, Buffex, Entercote, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Aspirin Low Strength (aspirin)
  • Benadryl (diphenhydramine)
  • caffeine (Vivarin, NoDoz, Caffedrine, Stay Awake, Cafcit, Jet Alert Regular Strength, Jet Alert Double Strength, Jet Alert Maximum Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Verv, Alert, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Diurex Ultra, Pep-Back Ultra, 357 HR Magnum, Enerjets, Fastlene, Keep Going, Molie, Overtime, Valentine)
  • Calcium 600 D (calcium / vitamin d)
  • codeine
  • Colace (docusate)
  • Cymbalta (duloxetine)
  • diclofenac (Voltaren, Cataflam, Cambia, Zorvolex, Zipsor, Voltaren-XR, Dyloject)
  • Eliquis (apixaban)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Advil Liqui-Gels, Proprinal, IBU-200, Motrin IB, Advil Migraine, Ibu-8, Motrin Childrens, Caldolor, Ibuprofen PMR, Nuprin, Childrens Ibuprofen Berry, Motrin Migraine Pain, Addaprin, NeoProfen, Advil Infant's Concentrated Drops, Ibu-Tab, Rufen, Genpril, Motrin Infant Drops, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Advil Children's, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Lasix (furosemide)
  • Lipitor (atorvastatin)
  • Lyrica (pregabalin)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • Metoprolol Succinate ER (metoprolol)
  • Metoprolol Tartrate (metoprolol)
  • Milk of Magnesia (magnesium hydroxide)
  • MiraLax (polyethylene glycol 3350)
  • Mucinex (guaifenesin)
  • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, Anaprox-DS, Naprelan, EC-Naprosyn, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, All Day Pain Relief, All Day Relief)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Percolone, RoxyBond, Oxydose, Oxyfast, Oxecta, Dazidox, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
  • prednisone (Deltasone, Sterapred, Rayos, Sterapred DS, Prednicot, Orasone, Meticorten, Liquid Pred, Prednicen-M)
  • ProAir HFA (albuterol)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Larapam SR, Ryzolt, Tramal SR, GenRx Tramadol, Zamadol, Tramedo, Zydol, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xarelto (rivaroxaban)
  • Zoloft (sertraline)
  • Zyrtec (cetirizine)

Acetaminophen alcohol/food interactions

There is 1 alcohol/food interaction with acetaminophen

Acetaminophen disease interactions

There are 3 disease interactions with acetaminophen which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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