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Acetaminophen Drug Interactions

A total of 182 drugs are known to interact with acetaminophen.

  • 14 major drug interactions
  • 74 moderate drug interactions
  • 94 minor drug interactions

Show all medications in the database that may interact with acetaminophen.

Check for interactions

Type in a drug name to check for interactions with acetaminophen.

Most frequently checked interactions

View interaction reports for acetaminophen and the medicines listed below.

  • aspirin (Ecotrin, Acetylsalicylic Acid, Aspir 81, Bayer Aspirin, Aspirin Low Strength, Bufferin, Arthritis Pain, Easprin, Ascriptin, Fasprin, Low Dose ASA, Buffered Aspirin, Aspir-Low, Durlaza, Ascriptin Enteric, Acuprin 81, Halfprin, Aspergum, Empirin, Bayer Children's Aspirin, Aspirin Lite Coat, Aspi-Cor, Aspirtab, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Entercote, Minitabs, St. Joseph Aspirin, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Aspiritab, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Bayer Aspirin Regimen, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Aspirin Low Strength (aspirin)
  • Benadryl (diphenhydramine)
  • caffeine (Vivarin, Caffedrine, Diurex Ultra, 357 HR Magnum, Overtime, Valentine, NoDoz, Jet Alert Regular Strength, Jet Alert Double Strength, Jet Alert Maximum Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Stay Awake, Verv, Alert, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Pep-Back Ultra, Cafcit, Enerjets, Fastlene, Keep Going, Molie)
  • Calcium 600 D (calcium / vitamin d)
  • codeine
  • Colace (docusate)
  • Cymbalta (duloxetine)
  • diclofenac (Voltaren, Cataflam, Cambia, Zorvolex, Zipsor, Voltaren-XR, Dyloject)
  • Eliquis (apixaban)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
  • ibuprofen (Advil, Motrin, IBU, Motrin IB, Advil Liqui-Gels, Motrin Childrens, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Ibuprofen PMR, Nuprin, NeoProfen, Proprinal, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Advil Infant's Concentrated Drops, Motrin Pediatric, Ibu-Tab, Rufen, Genpril, Haltran, IBU-200, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Motrin Migraine Pain, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Ibu-8, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Advil Film-Coated)
  • Lasix (furosemide)
  • Lipitor (atorvastatin)
  • Lyrica (pregabalin)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • Metoprolol Succinate ER (metoprolol)
  • Metoprolol Tartrate (metoprolol)
  • Milk of Magnesia (magnesium hydroxide)
  • MiraLax (polyethylene glycol 3350)
  • Mucinex (guaifenesin)
  • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, Naprelan, Anaprox-DS, Flanax Pain Reliever, EC-Naprosyn, Midol Extended Relief, Aflaxen, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Dazidox, Oxyfast, Oxecta, RoxyBond, Oxydose, Percolone, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Liquid Pred, Meticorten, Orasone, Prednicen-M)
  • ProAir HFA (albuterol)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramahexal, ConZip, Larapam SR, Ryzolt, Tramal SR, GenRx Tramadol, Tramahexal SR, Tramedo, Zydol, Zamadol, Zydol XL, Rybix ODT, Ultram ODT)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xarelto (rivaroxaban)
  • Zoloft (sertraline)
  • Zyrtec (cetirizine)

Acetaminophen alcohol/food interactions

There is 1 alcohol/food interaction with acetaminophen

Acetaminophen disease interactions

There are 3 disease interactions with acetaminophen which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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