Acetaminophen use while Breastfeeding
Medically reviewed by Drugs.com. Last updated on Mar 8, 2023.
Drugs containing Acetaminophen: Paracetamol, Tylenol, Percocet, Norco, Vicodin, Fioricet, Tylenol with Codeine #3, Panadol, Excedrin, Aceta, Show all 1054 »Lortab, Ultracet, Excedrin Migraine, Vicks NyQuil Cold & Flu Nighttime Relief, Percocet 10/325, Endocet, Tylenol Arthritis Pain, Tylenol with Codeine, Midol, Tylenol PM, Tylenol Extra Strength, Percocet 5/325, Mapap, Vicks NyQuil Severe Cold & Flu, Vicks DayQuil Severe Cold & Flu, Migraine Relief, Dologesic, Tylenol with Codeine #4, Coricidin HBP Cold & Flu, Ofirmev, Perfalgan, Vicks Dayquil Cold & Flu Relief, Darvocet-N 50, Esgic, Sudafed PE Sinus Pressure + Pain, Cough & Cold Relief, Dologen, Midrin, Darvocet-N 100, Children's Tylenol, Alka-Seltzer Plus Cold, Doliprane, Sinarest, Prolate, Headache Relief PM, Vicodin ES, Headache Relief, Percocet 7.5/325, Triad, Arthritis Pain Relief, Paracetamol Almus, Panadol Osteo, Advil Dual Action, Altenol, Feverall, Panadol ActiFast, Tencon, Fioricet with Codeine, Midol Complete, Codral Cold and Flu + Cough Day and Night, Mucinex Fast-Max Severe Cold, Theraflu Nighttime Severe Cold & Cough, Lorcet, Roxicet, Cetafen, Excedrin Tension Headache, Flextra, Tylenol Cold, Norel AD, Night Time Cold & Flu, Tylenol Cold & Flu Severe, Pamprin Cramp Menstrual Pain Relief, Menstrual Pain Relief, Pharbetol, Dafalgan, Panamax, Excedrin Extra Strength, Delsym Cough & Sore Throat, Cold Multi-Symptom (Daytime), Hycet, Percocet 10/650, Theraflu Flu & Sore Throat, Panadol Extend, Cipla Genpharm Paracetamol, Rex Paracetamol, Tactinal, Promax, KneeRelief, Vicks NyQuil Cold & Flu Nighttime Relief (Alcohol Free), Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Coricidin D, Tylenol with Codeine #1, Vicks NyQuil HBP Cold & Flu, Vicks Nyquil D Cold and Flu Nighttime Relief, Comtrex Cold & Cough, Pain Relief PM Extra Strength, Xartemis XR, Nalocet, Midol PMS Maximum Strength, Premsyn PMS, Anabar, Tylenol 8 Hour, Mapap Children's, Acephen, Buckley's Complete, Paracetamol Teva, Infant's Tylenol, Paralgin, Mapap Arthritis Pain, Coricidin HBP Maximum Strength Flu, Singlet, Sinutab Ex-Strength, Tylenol Cold Multi-Symptom Severe, Sudafed PE Cold & Cough, Percogesic Extra Strength, Tylenol Sinus Severe Day, Tylox, Primlev, Pamprin Maximum Pain, Tylenol Sinus + Headache Day, Lemsip Cold and Flu Liquid Capsule, Lemsip Original, A-Pak Laboratories Paediatric Analgesic Paracetamol, Tempra, Paracetamol Arrow, DG Health Pain Reliever, Calpol Six Plus, Masophen, Hedex, Valorin, Guardian Childrens Paracetamol, Pamprin Max Menstrual Pain Relief, Goody's Headache Powders, Migraine Formula, Backaid Inflammatory Pain Formula, Levacet, Painaid, Bupap, Esgic-Plus, DHC Plus, Prodrin, MigraTen, Triaminic Multi-Symptom Fever, Coricidin HBP Multi-Symptom Cold (Night), Theraflu Flu & Cough, Allpanto-S, XL-3 Cold Medicine, Cold Medicine Plus, Tylenol with Codeine #2, Diabetic Tussin Night Time Formula, NyCair, Mucinex Fast-Max Cold, Flu & Sore Throat, Mucinex Nightshift Severe Cold and Flu, Amidrine, Migrex, Acetadryl, Equate Allergy & Sinus Headache, Anexsia, Lorcet Plus, Vicodin HP, Dolagesic, Combogesic, Percocet 2.5/325, Xolox, Syncol, Alka-Seltzer Plus Cold and Sinus, Dolorex, Frenadol, Tylenol Childrens Paracetamol, 7T Gummy ES Chewable Tablets, Panadol Gel Caps, Hexal Comfarol, Abenol, Bristol Pharma Paracetamol, Gold Cross Paracetamol, Herron Gold Paracetamol Tabsules, Tempol, Conacetol, Efferalgan, Expandox, Actamin, Paracetamol Ranbaxy, Tycolene, Atasol, Alvedon, Lemsip Childrens Cold & Flu, Amcal Paracetamol Tabsules, RP Scherer Paracetamol, Excedrin Back & Body, Arthriten Inflammatory Pain Formula, Vanquish, Marten-Tab, Promacet, Vanatol LQ, Arcet, Repan, Orbivan, Menstrual Complete, Coricidin HBP Day & Night Multi-Symptom Cold, Tylenol Children’s Cold + Flu, Tylenol Cold Multi-Symptom Nighttime, XL-3 Xtra Cold and Cough, Cold Multi-Symptom (Nighttime), Childrens Tylenol Cold Plus Cough, Alka-Seltzer Plus-D Multi-Symptom Sinus & Cold Liquid Gels, Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, Alumadrine, Cocet Plus, Dologen 325, Drixoral Cough/Sore Throat, Delsym Night Time Cough & Cold, Tylenol Cold & Cough Nighttime, Tylenol Cold Multi-Symptom Nighttime Liquid, Decorel Forte Plus, Mucinex Sinus-Max Pressure, Pain & Cough, Adult Cold, Flu & Sore Throat, Daytime Cold & Flu, Neocitran Non Drowsy Extra Strength Cold and Flu, Daytime Cold and Flu Relief, Severe Cold Multi-Symptom, Mucinex Nightshift Cold & Flu, Diacetazone, Duradrin, Excedrin PM, Pain Reliever PM, Mucinex Fast-Max Night Time Cold & Flu, Mucinex Sinus-Max Day & Night (Night), Sudafed PE Nighttime Cold, CVS Allergy & Cold, Theraflu ExpressMax Nighttime Severe Cold & Cough, Benadryl Severe Allergy & Sinus Headache, Mucinex Fast-Max Cold & Sinus, Mucinex Sinus-Max Day & Night (Day), Duocet, Zydone, Xodol, Zolvit, Dual Action Pain Relief, Percocet 7.5/500, Oxycet, Pamprin Multi-Symptom Menstrual Relief, Talacen, Panadol Cold + Flu Non-Drowsy, 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Merck, Liquiprin, Paracetamol Qualimed, Adprin B, BF-Paradac, Paracetamol RPG, Tempra Quicklets, Paracetamol Sandoz, Paracetamol Sandoz Conseil, Lloydspharmacy Paracetamol Six Plus, Q-Pap, Paracetamol Winthrop, Triaminic Fever Reducer Pain Reliever, Lloydspharmacy Paracetamol Infant, Paracetamol Zydus, Triaminic Infant Drops, Atasol Forte, Paralyoc, Tylenol Cool Caplet Extra Strength, Perfalgan Nourrissons Et Enfants, Acetaminophen-odan, Mapap Rapid Tabs, Jr. Tylenol, Mapap Extra Strength Rapid Burst, Elixsure Fever/Pain, Infadrops, Disprol Soluble Paracetamol, Calpol Infant, Disprol Paracetamol, Galpamol, Paldesic, Calpol Paediatric, Medinol Paediatric, Medinol Under 6, Infantaire Drops, Lemsip Pharmacy Non-Decongestant Formula, Calpol Fastmelts, Aminofen, Medinol Over 6, Nortemp Children's, Paracets, Anadin Paracetamol, UN-Aspirin Extra Strength, Mandanol, Actimol Children's, Dakota Paracetamol, Miradol, Umphamol, Remedol, Panamax 240, Parahexal, Febridol, Mid West Products Numol 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Comtrex Acute Head Cold, Dristan Cold Maximum Strength, Phrenilin Forte (old formulation), Orbivan CF, Allzital, Triaprin, Bucet, Sedapap, Dolgic, Prominol, Cephadyn, Butex Forte, Axocet, Phrenilin, Phrenilin Forte, Alagesic LQ, Vtol LQ, Isocet, Pharmagesic, Anoquan, Two-Dyne, Tenake, Margesic, Anolor 300, Femcet, Geone, Tencet, Fiorpap, Dolmar, Endolor, Ezol, Ide-cet, G-1, Medigesic, Minotal, Mygracet, Pacaps, Alagesic, Americet, Zebutal, Nonbac, Vanatol S, Dolgic Plus, Dolgic LQ, Capacet, Phrenilin with Caffeine and Codeine, Excedrin Mild Headache, Valorin Extra, Excedrin Quick Tab, Hycomine Compound, Sinapils, Panlor DC, Panlor SS, Panlor, Trezix, Dvorah, Zerlor, Emagrin Forte (old formulation), Migralam, Combiflex ES, Durabac Forte, Cafgesic Forte, Saleto-D, Flextra Plus, Combiflex, Cafgesic, Durabac, Menstrual Relief Extra Strength, Menstrual Relief Maximum Strength, Menstrual Relief, Rid-A-Pain Compound, Ninjacof-A, Congestant, 999 Cold Remedy Granular, Cotabflu, Colrex Compound, Colrex, Tylenol Children’s Cold + Cough + Runny Nose, PediaCare Cough & Runny Nose Plus Acetaminophen, Flu HBP Maximum Strength, Mapap Cough & Sinus Formula, Vicks Formula 44 Custom Care Cough & Cold PM, Flu Relief BP, Tylenol Cold and Flu Severe Day & Night, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), PediaCare Multi-Symptom Cold Plus Acetaminophen, PediaCare Flu Plus Acetaminophen, Alka-Seltzer Plus Severe Cold & Flu PowerFast Fizz, Alka-Seltzer Plus Maximum Strength Sinus Congestion & Pain PowerFast Fizz, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Alka-Seltzer Plus Maximum Strength Cold & Cough, Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Maximum Strength Cold & Cough Liquid Gels, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold, Giltuss Multi-Symptom Cold & Flu, Giltuss Children's Multi-Symptom Cold & Flu, Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and Flu Maximum Stength, Theraflu Flu, Cold and Cough Powder, Comtrex Day and Night, Cough Formula M Multi-Symptom, Comtrex Cold and Flu Maximum Strength Tablet, Comtrex Cold and Flu Maximum Strength Liquid, Genacol Maximum Strength, Contac Cold and Flu Maximum Strength, Co-Apap, Theracaps Multi-Symptom Cough & Cold Reliever, Triaminic Flu, Cough & Fever, Gelpirin-CCF, Contac Cold + Flu (Night Formula), Medicidin-D, BC Sinus Pain & Congestion, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, GNP Cold Relief Plus, Super Strength Sinadrin, Gendecon, Dristan Cold Multi Symptom Formula, Tylenol Allergy Multi-Symptom, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Protid, Hybrid CF, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, HEB Allergy, Dryphen, Covangesic, Norel SR, Trital SR, Rhinogesic, Duadacin, Sinulin, Chlor-Trimeton Sinus, Comtrex Sinus and Nasal, Comtrex Nighttime Flu Therapy, Simplet, Tricom, Comtrex Allergy Sinus, Codimal, Kolephrin, Allerest Sinus, Tylenol Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Allerest Headache Strength, Sinarest Extra Strength, Triaminicin, Sinutab Maximum Strength Caplets, Allergy Sinus Maximum Strength, Actifed Cold & Sinus, Tavist Allergy/Sinus/Headache, EZ III, Phenaphen with Codeine, Capital with Codeine Suspension, Aceta w/ Codeine, Capital w/Codeine, Cocet, Codrix, Phenflu CDX, Phenflu CD, Maxiflu CD, Maxiflu CDX, G-Dologen, Dologesic NF, Actidogesic, Drixoral Cold/Flu, Complete Sinus Relief, Sinadrin Plus, Drixoral Allergy Sinus, Drixoral Cold and Flu, Drixoral Sinus, Hexaflu, Tylenol Children’s Cold + Cough + Sore Throat, PediaCare Cough & Sore Throat Plus Acetaminophen, Triaminic Cough & Sore Throat, Tylenol Cough and Sore Throat Daytime, Triaminic Softchews Cough & Sore Throat, Children's Triacting, Tylenol Cold & Cough Daytime, Topcare Cough and Sore Throat, Vicks DayQuil HBP Cold & Flu, Diabetic Tussin Night Time Cold & Flu, Mucinex Fast-Max Day Time Severe Cold and Night Time Cold & Flu Maximum Strength, Mucinex Fast-Max Day Time Cold & Flu and Night Time Cold & Flu Maximum Strength, Mucinex Fast-Max Day Time Severe Congestion & Cough and Night Time Cold & Flu Maximum Strength, Mucinex Children's Day Time & Night Time Multi-Symptom Cold Value Pack, Respa C&C, Respa C&C IR, Contac Day and Night Cold and Flu, Robitussin Peak Cold Nighttime Cold + Flu, Contac Cold + Flu (Night) Cooling Relief Liquid, Robitussin Cold + Flu (Nighttime), Coricidin HBP Nighttime Multi-Symptom Cold, Vicks Nature Fusion Cold & Flu Nighttime Relief, Multi Symptom NiteTime, Night Time Multi Symptom Cold/Flu Relief, Alka-Seltzer Plus Severe Cold+Cough Night Liquid, Tylenol Cough & Sore Throat Nightime, Clear Cough PM Multi-Symptom, Mucinex Fast-Max Day & Night, Mucinex Sinus-Max Day & Night, DayQuil/NyQuil Severe Cold and Flu, Mucinex Fast-Max Day Severe Cold and Night Cold & Flu, Delsym Night Time Multi-Symptom, Alka-Seltzer Plus Night Cold Formula Liquid, Alka-Seltzer Plus Multi-Symptom Cold & Flu (Night Formula), Alka-Seltzer Plus Severe Sinus Congestion & Cough (Night Formula), Mucinex Fast-Max Night Time Cold & Flu Liquid Gels, Alka-Seltzer Plus Severe Sinus Congestion, Allergy & Cough Liquid Gels, Alka-Seltzer Plus Maximum Strength Night Cold & Flu Liquid Gels, Alka-Seltzer Plus Maximum Strength Day & Night Cold & Flu Liquid Gels (Night Formula), Alka-Seltzer Plus Multi-Symptom Cold & Flu Day & Night Liquid Gels (Night Formula), Alka-Seltzer Plus Night Severe Cold+Flu Hot Drink Mix, All-Nite Cold, Tylenol Severe Cold & Flu Night Time, Multi-Symptom Nighttime, All-Nite Multi-Symptom Cold/Flu Relief, Coricidin HBP Cold Cough and Flu Maximum Strength, Mucinex Sinus-Max Pressure, Pain & Cough and Sinus-Max Clear & Cool Nasal Spray, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Children's Multi-Symptom Cold & Fever, Mucinex Children's FreeFrom Multi-Symptom Cold, Flu & Sore Throat, Delsym Cough+ Cold Day Time, Sudafed PE Head Congestion + Flu Severe, Mucinex Fast-Max Day Time Severe Cold, Non-Pseudo Cold Relief, Tylenol Cold + Mucus Severe, Mucinex Fast-Max Cold, Flu & Sore Throat Liquid Gels, CounterAct Day, Tylenol Cold Head Congestion Severe (old formulation), Mucinex Fast-Max Severe Congestion & Cold, Alka-Seltzer Plus Severe Cough, Mucus & Congestion Liquid Gels, Alka-Seltzer Plus Severe Sinus, Cold & Cough Liquid Gels, Phenflu DM, Alka-Seltzer Plus Severe Cold, Mucus & Congestion, Alka-Seltzer Plus Day Severe Cold+Flu Hot Drink Mix, Rompe Pecho MAX, Cold Head Congestion, Cold Multi-Symptom Severe, ConRx Cold, Robitussin Severe Multi-Symptom Cough Cold + Flu, Mucus Relief Complete, Mucus Relief Plus, Cold & Cough PE Multi-Symptom, Suphedrine PE Cold & Cough, Sudafed PE Pressure+Pain+Cold, Tylenol Cough & Severe Congestion Daytime, Mucinex FreeFrom Cold & Flu Daytime and FreeFrom Cold & Flu Nighttime, Mucinex Fast-Max Severe Congestion & Cough and Nightshift Cold & Flu, Anatuss, Robitussin Cold Cough and Flu, Tylenol Cold Severe Congestion Daytime, Phlemgesic, Balminil Cough and Flu Sugar Free, Theraflu Max-D Severe Cold & Flu, Flutabs, Duraflu, Maxiflu DM, Tusnel-A, Mucinex Fast-Max DM Max and Nightshift Cold & Flu, Mucinex Fast-Max DM Max & Mucinex Nightshift Cold & Flu, Robitussin Peak Cold Daytime Cold + Flu, Contac Complete Cough, Cold & Flu Extra Strength, Tylenol Plus Children's Cold & Cough, Robitussin Cold + Flu (Daytime), Mapap Cold Formula, BC Cough & Cold, Little Colds Multi-Symptom, Vicks Nature Fusion Cold & Flu Multi-Symptom Relief, Theraflu Daytime Severe Cold & Cough, Comtrex Cold and Cough Maximum Strength, Day Relief PE, Vicks Dayquil Cold & Flu Symptom Relief Plus Vitamin C, Day Time Multi-Symptom Cold/Flu Relief, Mucinex Fast-Max Congestion & Headache, Multi Symptom Cold (Day Formula), Alka-Seltzer Plus Severe Sinus Congestion & Cough Liquid Gels, Alka-Seltzer Plus Maximum Strength Day Cold & Flu Liquid Gels, Alka-Seltzer Plus Multi-Symptom Cold & Flu Day Liquid Gels, Theraflu Multi-Symptom Severe Cold with Lipton Flavors, Theraflu Warming Relief Daytime Multi-Symptom Cold Caplets, Theraflu Warming Relief Daytime Severe Cold & Cough, Tylenol Cold Max Day, Tylenol Cold Head Congestion Daytime, Sudafed PE Pressure+Pain+Cough, Flu & Severe Cold & Cough Daytime Powder, Theraflu ExpressMax Daytime Severe Cold & Cough, Mucinex Children's FreeFrom Multi-Symptom Cold & Flu Nighttime, Mucinex Nightshift Sinus, Mucinex Nightshift Cold & Flu Clear & Cool, Mucinex Nightshift Sinus Clear & Cool, Comtrex Non Drowsy Liquigel, Theraflu Flu Cold & Cough, Tylenol Cold + Flu Multi-Action, Alka-Seltzer Plus Flu/Body, Vicks Dayquil Daytime Cold/Flu (old formulation), Comtrex Non-Drowsy, Contac Severe Cold and Flu Non Drowsy, Day Time Multi Symptom, Non-Drowsy Super Strength Contac Complete, Contact Cold and Sore Throat, Day Relief Cold and Flu, Tylenol Cold Non-Drowsy Gelcaps, Daytime Non-Drowsy, Theraflu (pseudoephedrine) Daytime Severe Cold, Daytime Cold, Migragesic IDA, LarkaDrin, Nodolor, Migrazone, Isocom, Migrapap, Migratine, Mitride, Migquin, IDA, Midchlor, Alidrin, Iso-Acetazone, Epidrin, Migrin-A, Bayer Select Max Strength Night Time Pain, ConRx PM, Night Time Pain, Percogesic Original Strength, Unisom PM Pain, Genapap PM, Mapap PM, Counteract PM Extra Strength, Midol PM, Wal-Nadol PM Extra Strength, Headache Formula PM, Sominex Pain Relief Formula, Legatrin PM, Coricidin Night Time Cold Relief, Tylenol Sore Throat Nighttime, Pharbetol PM, Non-Aspirin PM Extra Strength, Acetaminophen PM Extra Strength, Aceta-Gesic, Tylenol Severe Allergy, Anacin PM Aspirin Free, Mucinex Sinus-Max Day and Night Maximum Strength, Dimetapp Children's Multi-Symptom Cold & Flu, Tylenol Plus Children's Cold & Allergy, Sudafed PE Severe Cold, Theraflu Warming Relief Nighttime Severe Cold & Cough, Delsym Cough+ Cold Night Time, Delsym Children’s Cough+ Cold Night Time, Mucinex Sinus-Max Night Time Congestion & Cough, Night Time Severe Cold and Cough, Suphedrine PE Severe Cold, CounterAct Night, Robitussin Multi-Symptom Cold Night Time, Mucinex Children's Night Time Multi-Symptom Cold, Theraflu Warming Relief Flu & Sore Throat, Benadryl Severe Allergy Plus Sinus Headache, Severe Allergy and Sinus Headache, Tylenol Allergy Multi-Symptom Nighttime, CVS Allergy & Sinus Headache, Children's Tylenol Plus Cold And Allergy, Robitussin Severe Multi-Symptom Cough Cold + Flu Nighttime, Theraflu Warming Relief Sinus & Cold, Theraflu ExpressMax Flu, Cough & Sore Throat, Benadryl Allergy Plus Cold, 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Acetaminophen Levels and Effects while Breastfeeding
Summary of Use during Lactation
Acetaminophen is a good choice for analgesia, and fever reduction in nursing mothers. Amounts in milk are much less than doses usually given to infants. Adverse effects in breastfed infants appear to be rare.
Drug Levels
Maternal Levels. A single oral dose of 650 mg of acetaminophen was given to 12 nursing mothers who were 2 to 22 months postpartum. Peak milk levels of 10 to 15 mg/L occurred between 1 and 2 hours after the dose in all patients. Acetaminophen was undetectable (<0.5 mg/L) in all mothers 12 hours after the dose. The authors calculated that an infant who ingested 90 mL of breastmilk every 3 hours would receive an average of 0.88 mg of acetaminophen or 0.14% (range 0.04 to 0.23%) of the mother's absolute dosage.[1] Using data from this study, an infant would receive a maximum of about 2% of the maternal weight-adjusted dosage.
Three women took a single 500 mg dose of acetaminophen. Peak milk levels averaging 4.2 mg/L occurred within 2 hours after the dose.[2] Using data from this study, an infant would receive a maximum of about 3.6% of the maternal weight-adjusted dosage.
Four women who were 2 to 8 months postpartum were given a single 1 gram dose of acetaminophen. Milk was completely emptied from one breast every 30 minutes for 3 to 3.5 hours, with a final sample from the opposite breast. Peak milk levels occurred between 1 and 2.5 hours after the dose. The acetaminophen level in the breast that was sampled only once had a lower level than the breast sampled at half-hour intervals. The authors estimated that a breastfed infant would receive an average of 1.1% and a maximum of 1.8% of the maternal weight-adjusted dosage. This dose is about 0.5% of the lowest recommended infant dose of acetaminophen.[3]
Infant Levels. No acetaminophen was detected in the urine of 12 breastfed infants aged 2 to 22 months after maternal ingestion of 650 mg of acetaminophen.[4]
Urine was collected for 1 to 3.5 hours after nursing in 6 infants aged 2 to 6 days whose mothers received 1 to 2 grams of acetaminophen 2 to 4 hours before nursing their infant. Infants excreted an average of 401 mcg of acetaminophen and its metabolites in urine during the collection interval. These neonates excreted a greater percentage of drug as acetaminophen and much less as the sulfate metabolite than in an adult comparison population.[3]
Effects in Breastfed Infants
A maculopapular rash on the upper trunk and face of a 2-month-old infant was probably caused by acetaminophen in breastmilk. The rash occurred after 2 days of therapy in the mother at a dose of 1 gram at bedtime. It subsided when the drug was discontinued and recurred 2 weeks later after another acetaminophen dose of 1 gram was taken by the mother.[5]
Two papers report 14 women who breastfed after taking acetaminophen or its prodrug phenacetin with no adverse effects to their infants.[4,6]
In a telephone follow-up study, mothers reported no side effects among 43 infants exposed to acetaminophen in breastmilk.[7]
Two clinicians speculated that breastmilk exposure to acetaminophen during breastfeeding might be a risk factor for asthma and wheezing in the breastfed infants based on their personal observations.[8] However, these observations were uncontrolled and cannot be considered to be valid proof of an association.[9]
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
- 1.
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Berlin CM Jr, Yaffe SJ, Ragni M. Disposition of acetaminophen in milk, saliva and plasma of lactating women. Pediatr Pharmacol (New York). 1980;1:135–41. [PubMed: 7202185]
- 2.
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Bitzén PO, Gustafsson B, Jostell KG, et al. Excretion of paracetamol in human breast milk. Eur J Clin Pharmacol. 1981;20:123–5. [PubMed: 7262173]
- 3.
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Notarianni LJ, Oldham HG, Bennett PN. Passage of paracetamol into breast milk and its subsequent metabolism by the neonate. Br J Clin Pharmacol. 1987;24:63–7. [PMC free article: PMC1386281] [PubMed: 3620287]
- 4.
-
Berlin CM Jr, Yaffe SJ, Ragni M. Disposition of acetaminophen in milk, saliva and plasma of lactating women. Pediatr Pharmacol. 1980;1:135–41. [PubMed: 7202185]
- 5.
-
Matheson I, Lunde PKM, Notarianni L. Infant rash caused by paracetamol in breast milk? Pediatrics 1985;76:651-2. Letter. PMID: 2931668. [PubMed: 2931668]
- 6.
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Findlay JW, DeAngelis RL, Kearney MF, et al. Analgesic drugs in breast milk and plasma. Clin Pharmacol Ther. 1981;29:625–33. [PubMed: 7214793]
- 7.
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Ito S, Blajchman A, Stephenson M, et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393–9. [PubMed: 8498418]
- 8.
-
Verd S, Nadal-Amat J. Paracetamol and asthma and lactation. Acta Paediatr. 2011;100:e2–3. [PubMed: 21244486]
- 9.
-
Bakkeheim E, Carlsen KH, Lodrup Carlsen KC. Paracetamol exposure during breastfeeding and risk of allergic disease. Acta Paediatr. 2011;100:e3. [CrossRef]
Substance Identification
Substance Name
Acetaminophen
CAS Registry Number
103-90-2
Drug Class
Breast Feeding
Lactation
Analgesics, Non-Narcotic
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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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