Generic Name: acetaminophen (injection) (a SEET a MIN oh FEN)
Brand Name: Ofirmev
Medically reviewed by Philip Thornton, DipPharm. Last updated on March 4, 2021.
What is Ofirmev injection?
Ofirmev injection is sometimes given with opioid pain medication to treat moderate to severe pain in adults and children at least 2 years old.
Ofirmev injection may also be used for purposes not listed in this medication guide.
You should not use Ofirmev if you have severe liver disease.
Do not use more Ofirmev than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).
Be very careful when measuring your dose. Ofirmev contains 10 milligrams (mg) of acetaminophen in each milliliter (mL) of the solution.
In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. Stop using Ofirmev and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.
Before taking this medicine
You should not use Ofirmev if you are allergic to acetaminophen, or if you have severe liver disease.
To make sure Ofirmev is safe for you, tell your doctor if you have ever had:
kidney disease; or
if you are malnourished.
Tell your doctor if you are pregnant or breastfeeding.
Ofirmev may affect fertility (your ability to have children), whether you are a man or a woman.
How is Ofirmev injection given?
Ofirmev is given as an infusion into a vein, usually once every 4 to 6 hours. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
Be very careful when measuring your dose. Ofirmev injection contains 10 milligrams (mg) of acetaminophen in each milliliter (mL) of the solution. If your dose is 1000 mg, for example, you would use only 100 mL of solution.
If you are using an infusion pump, take care to properly program the machine to deliver the correct amount of medicine for your dose.
Tell your doctor if you have any changes in weight while using this medicine. Lower doses are used in people who weigh less than 110 pounds (50 kilograms).
Do not use more Ofirmev than is recommended. An overdose of acetaminophen can damage your liver or cause death.
Each Ofirmev vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.
Store at room temperature away from heat and moisture. Do not refrigerate or freeze.
You must use the medicine within 6 hours after opening a vial.
What happens if I miss a dose?
Since Ofirmev is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
Do not use Ofirmev injection more often than every 4 hours.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can damage your liver or cause death.
Overdose symptoms may also include hunger with irritability, fast heart rate, tremors, feeling jittery, trouble concentrating, easy bruising, unusual bleeding, or purple or red pinpoint spots under your skin.
What should I avoid while using Ofirmev injection?
Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen (sometimes abbreviated as APAP). Using too much acetaminophen can lead to a fatal overdose.
Avoid drinking alcohol. It may increase your risk of liver damage.
Ofirmev injection side effects
Get emergency medical help if you have signs of an allergic reaction to Ofirmev: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop using this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.
Stop using Ofirmev and call your doctor at once if you have:
chest pain, trouble breathing; or
liver problems - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common Ofirmev side effects may include:
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Ofirmev injection?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may interact with acetaminophen, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Yes, it is safe to take ibuprofen and acetaminophen together if you need to for extra pain relief. Taking ibuprofen and acetaminophen together is quite an effective combination for pain relief because they work in different ways and have different side effects. But you should only take them together if you need to, and only if it is safe to do so. And you should never take more than the recommended dosage of either ibuprofen or acetaminophen. Continue reading
Paracetamol is known as acetaminophen in the U.S. Acetaminophen relieves mild-to-moderate pain, headache and fever. It's available over-the-counter as brand names such as Tylenol, Mapap or Panadol, and also as generics and store-specific brands. There are no differences in the chemical or therapeutics uses of acetaminophen and paracetamol, although recommended doses or available products may differ between countries. Continue reading
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More about Ofirmev (acetaminophen)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Generic Availability
- Drug class: miscellaneous analgesics
- FDA Alerts (14)
- FDA Approval History
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ofirmev only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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