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Rimegepant

Generic name: rimegepant (ri ME je pant)
Brand name: Nurtec ODT
Drug class: CGRP inhibitors

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 24, 2020.

What is rimegepant?

Rimegepant is a calcitonin gene-related peptide receptor antagonist.

Rimegepant is a prescription medicine used in adults to treat a migraine headache with or without aura.

Rimegepant is not used as a preventive treatment of migraine.

Rimegepant (Nurtec ODT) is supplied as an orally disintegrating tablets (ODT) for sublingual (under the tongue) or oral use.

Warnings

It is not known if it is safe to take rimegepant ODT for more than 15 migraine headaches in 30 days.

Rimegepant ODT can be taken 1 time each day as needed. You should not take more than 1 tablet in 24 hours.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

If you take too much rimegepant ODT, go to the nearest emergency room right away.

Before taking this medicine

You should not use rimegepant if you are allergic to it.

To make sure rimegepant is safe for you, tell your doctor if you have ever had:

It is not known whether rimegepant will harm an unborn baby. However, having migraine headaches may cause complications during pregnancy such as dangerously high blood pressure that can lead to medical problems in both mother and baby. The benefit of treating migraines may outweigh any risks to the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Rimegepant is not approved for use by anyone younger than 18 years old.

How should I take rimegepant?

Use rimegepant ODT exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Call your doctor if your symptoms do not improve, or if you have more than 15 headaches in one month (30 days).

Remove an orally disintegrating tablet from the package only when you are ready to take the medicine.

  • Use dry hands when opening the blister pack.

  • Peel back the foil covering of one blister and gently remove the orally disintegrating tablet (ODT). Do not push the ODT through the foil.

  • As soon as the blister is opened, remove the ODT and place on the tongue; alternatively, the ODT may be placed under the tongue.

  • The ODT will disintegrate in saliva so that it can be swallowed without additional liquid.

  • Swallow several times as the tablet dissolves.

  • Take the ODT immediately after opening the blister pack. Do not store the ODT outside the blister pack for future use.

Store at cool room temperature, away from moisture and heat.

Dosing information

Usual Adult Dose for Migraine:

75 mg orally
Maximum dose: 75 mg in a 24-hour period

Comments:
-This drug is not for the preventive treatment of migraine.
-The safety of treating more than 15 migraines in a 30-day period is unknown.

Use: For the acute treatment of migraine with or without aura.

Place on tongue (or under tongue) and allow to disintegrate in saliva and swallow; additional liquid is not necessary. Do not take more than 1 dose in 24-hours.

What happens if I miss a dose?

Since rimegepant is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using this medicine.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Rimegepant side effects

Get emergency medical help if you have signs of an allergic reaction to rimegepant: hives, rash; difficult breathing; swelling of your face, lips, tongue, or throat.

An allergic reaction can be severe, and may occur days after you have taken this medicine.

Common rimegepant side effects may include nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect rimegepant?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

If you use any of the following medicines, avoid taking rimegepant within 48 hours after you last took the other medicine:

This list is not complete and many other drugs may interact with rimegepant. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use rimegepant only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.