Skip to Content
Diagnosed with AS? Biologics can help >

Xeljanz (tofacitinib) Drug Interactions

A total of 417 drugs are known to interact with Xeljanz (tofacitinib).

  • 287 major drug interactions
  • 128 moderate drug interactions
  • 2 minor drug interactions

Show all medications in the database that may interact with Xeljanz (tofacitinib).

Check for interactions with Xeljanz (tofacitinib)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Xeljanz (tofacitinib)

  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • Arava (leflunomide)
  • Aspirin Low Strength (aspirin)
  • Cymbalta (duloxetine)
  • Enbrel (etanercept)
  • folic acid (Folvite, Folacin-800, FaLessa, FA-8)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • Humira (adalimumab)
  • hydroxychloroquine (Plaquenil, Quineprox)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Children's Motrin, Motrin Migraine Pain, Advil Migraine, Caldolor, Ibuprofen PMR, Advil Children's, Addaprin, NeoProfen, Advil Infant's Concentrated Drops, A-G Profen, Motrin Childrens, Childrens Ibuprofen Berry, Ibu-6, Ibu-8, Motrin Infant Drops, Ibu-Tab, Rufen, Genpril, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • leflunomide (Arava)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Unithroid, Levothyrox, Euthyrox, Levo-T, L Thyroxine Roche, Eutroxsig, Novothyrox, Oroxine, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • losartan (Cozaar)
  • Lyrica (pregabalin)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • methotrexate (Trexall, Rasuvo, Otrexup, Methotrexate LPF Sodium, Xatmep, Rheumatrex Dose Pack, Folex PFS)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Percolone, Oxyfast, Dazidox, RoxyBond, Oxecta, Oxydose, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
  • Plaquenil (hydroxychloroquine)
  • prednisone (Deltasone, Rayos, Sterapred DS, Sterapred, Prednicot, Meticorten, Liquid Pred, Orasone, Prednicen-M)
  • tizanidine (Zanaflex)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Tramedo, Ultram ER, Larapam SR, GenRx Tramadol, ConZip, Zydol, Ryzolt, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • Tylenol (acetaminophen)
  • Vitamin D3 (cholecalciferol)

Xeljanz (tofacitinib) alcohol/food interactions

There is 1 alcohol/food interaction with Xeljanz (tofacitinib)

Xeljanz (tofacitinib) disease interactions

There are 11 disease interactions with Xeljanz (tofacitinib) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide