Meloxicam Side Effects
Medically reviewed by Drugs.com. Last updated on Jun 3, 2022.
More frequently reported side effects include: abdominal pain, anemia, and edema. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to meloxicam: intravenous solution
Intravenous route (Solution)
NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. Meloxicam is contraindicated in the setting of coronary artery bypass graft surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.
Side effects requiring immediate medical attention
Along with its needed effects, meloxicam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking meloxicam:
- Abdominal or stomach pain, cramping, burning, or tenderness
- bloody or black, tarry stools
- dark urine
- decreased appetite
- itching or skin rash
- loss of appetite
- nausea and vomiting
- swelling of the feet or lower legs
- trouble breathing
- unusual tiredness or weakness
- vomiting of material that looks like coffee grounds, severe and continuing
- yellow eyes or skin
Incidence not known
- Blistering, peeling, or loosening of the skin
- bloody or cloudy urine
- cough or hoarseness
- decrease in the frequency of urination
- decrease in urine volume
- difficulty in passing urine (dribbling)
- difficulty swallowing
- fast heartbeat
- fever with or without chills
- general feeling of tiredness or weakness
- greatly decreased frequency of urination or amount of urine
- lower back or side pain
- pains in the chest, groin, or legs, especially calves of the legs
- painful or difficult urination
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red, irritated eyes
- severe headaches of sudden onset
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- sudden loss of coordination
- sudden onset of shortness of breath for no apparent reason
- sudden onset of slurred speech
- sudden vision changes
- swelling of the feet or lower legs
- tightness in the chest
- unusual bleeding or bruising
Side effects not requiring immediate medical attention
Some side effects of meloxicam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
For Healthcare Professionals
Applies to meloxicam: intravenous dispersion, oral capsule, oral suspension, oral tablet, oral tablet disintegrating
Very rare (less than 0.01%): GI perforation
Frequency not reported: Dry mouth, duodenal ulcer, gastric ulcer, gastritis, hematemesis, hemorrhagic duodenal ulcer, hemorrhagic gastric ulcer, intestinal perforation, melena, pancreatitis, perforated duodenal ulcer, perforated gastric ulcer, stomatitis ulcerative[Ref]
Common (1% to 10%): Hypertension
Uncommon (0.1% to 1%): Flushing
Rare (less than 0.1%): Palpitations
Common (1% to 10%): Dizziness, headache, carpel tunnel syndrome
Uncommon (0.1% to 1%): Somnolence
Rare (less than 0.1%): Asthma
Frequency not reported: Bronchospasm[Ref]
Frequency not reported: Face edema, fever, malaise, weight decreased, weight increased, tinnitus
Common (1% to 10%): Anemia
Rare (0.01% to 0.1%): Blood count abnormal, leukopenia, thrombocytopenia
Uncommon (0.1% to 1%): Angioedema
Very rare (less than 0.01%): Dermatitis bullous, erythema multiforme
Frequency not reported: Alopecia, bullous eruption, exfoliative dermatitis, photosensitivity reaction, sweating increased
Postmarketing reports: Erythema multiforme[Ref]
Common (1% to 10%): Hypersensitivity
Uncommon (0.1% to 1%): Allergic reactions
Frequency not reported: Anaphylactoid reaction
Postmarketing reports: Anaphylactoid reactions including shock[Ref]
Postmarketing reports: Female infertility[Ref]
Common (1% to 10%): Arthralgia, aggravated arthralgia, joint crepitation, joint effusion, joint swelling, back pain, osteoarthritis, pain in extremity, arthritis, bursitis, muscle spasms, myalgia, rheumatoid arthritis[Ref]
Common (1% to 10%): Micturition frequency, urinary tract infection, hematuria
Uncommon (0.1% to 1%): Liver function disorder, ALT increased, AST increased, bilirubinemia
Very rare (less than 0.01%): Hepatitis
Common (1% to 10%): Insomnia
Rare (less than 0.1%): Nightmares, mood alterations
Postmarketing reports: Alterations in mood such as mood elevation[Ref]
Very rare (less than 0.01%): Acute renal failure, papillary necrosis, acute tubular necrosis
Frequency not reported: Albuminuria, BUN increased, creatinine increased, interstitial nephritis, renal failure[Ref]
Common (1% to 10%): Dehydration, appetite increased
Common (1% to 10%): Cataract
Rare (less than 0.1%): Visual disturbances, conjunctivitis, blurred vision
Frequency not reported: Abnormal vision[Ref]
Frequently asked questions
- Meloxicam vs Ibuprofen, what's the difference?
- Can I take Meloxicam and Aleve or Tylenol together?
- Which painkiller should you use?
- Should I take meloxicam at night or in the morning?
- How long do I wait after taking ibuprofen to take meloxicam?
- Is meloxicam very similar to Celebrex?
- Can meloxicam cause drowsiness and headache?
- Is meloxicam a narcotic?
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- Is meloxicam a sulfa drug?
More about meloxicam
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- Dosage information
- During pregnancy or Breastfeeding
- Reviews (552)
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- Drug class: Nonsteroidal anti-inflammatory drugs
- Drug Information
- Meloxicam Intravenous (Advanced Reading)
- Meloxicam Orally-Disintegrating Tablets
- Meloxicam Capsules
- Meloxicam Suspension
- Meloxicam Tablets
Related treatment guides
1. "Product Information. Mobic (meloxicam)." Boehringer-Ingelheim (2001):
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. MHRA. Medicines and Health Regulatory Agency "MHRA Drug Safety Update. http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate." (2013):
4. "Product Information. Anjeso (meloxicam)." Baudax Bio, Inc. (2020):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.