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User Reviews for Duloxetine

Also known as: Cymbalta, Irenka

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Duloxetine.

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Condition DownUp Reviews Compare Avg. Ratings DownUp
Persistent Depressive Disorder 1 reviews 3 medications
   
10
Pain 65 reviews 1100 medications
   
7.4
Anxiety 176 reviews 56 medications
   
7.0
Osteoarthritis 23 reviews 350 medications
   
7.0
Generalized Anxiety Disorder 89 reviews 7 medications
   
6.8
Bipolar Disorder 32 reviews 29 medications
   
6.7
Hot Flashes 9 reviews 19 medications
   
6.7
Diabetic Peripheral Neuropathy 33 reviews 40 medications
   
6.7
Depression 464 reviews 79 medications
   
6.6
Fibromyalgia 202 reviews 20 medications
   
6.5
Major Depressive Disorder 49 reviews 46 medications
   
6.4
Back Pain 27 reviews 178 medications
   
6.4
Peripheral Neuropathy 26 reviews 6 medications
   
6.3
Small Fiber Neuropathy 1 reviews 0 medications
   
6.0
Chronic Pain 98 reviews 108 medications
   
6.0
Chronic Fatigue Syndrome 5 reviews 2 medications
   
5.7
Urinary Incontinence 4 reviews 49 medications
   
4.4
Summary of Duloxetine reviews 1304 reviews 6.6

Reviews for Duloxetine

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For Fibromyalgia: "Started on 30 mg XR. Didn't make it passed 3 days. This drug was really hard on my body. Nausea, vomiting, diarrhea, excruciating acid reflux, sweating, pupil dilation, tremors and depersonalization were all experienced. The only way this drug would be helpful would be is if they made it in smaller doses. It did, however, help my nerve pain. The pamphlet says specifically not to open the capsule and dump out some of the enteric coated beads, but this is the only way I could see this drug being tolerable."

   
2.0

lumberguy (taken for less than 1 month) September 17, 2017

1 users found this comment helpful.

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Cymbalta (duloxetine) for Depression: "I took my first dose of generic Cymbalta last night of 60 milligrams. It's now 5:47 PM & I've not eaten all day due to the severe nausea. I'm also very jittery, anxious, have a super, really bad headache (I'm also prone to migraines.), & my tinnitus is worse in my left ear. I also have slept most of the day, besides. I have depression & mild PTSD & anxiety & migraines, I've been on other anti-depressants before. Prozac increased my migraines the last time. I think this generic of Cymbalta won't be for me."

   
1.0

Seriouscatlady (taken for less than 1 month) September 16, 2017

1 users found this comment helpful.

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Cymbalta (duloxetine) for Fibromyalgia: "Cymbalta seems to me like a "miracle" in ridding me of fibromyalgia pain. I have had fibro symptoms of varying severity for over 30 years (I am 58), and I have never found lasting relief, except for one year when I did not work, studied massage therapy, and got massages several times a week. Recently, severe pain returned in my hips which prevented me from sleeping. My doctor subscribed the generic version of Cymbalta (duloxetine), and within a few days the pain was greatly reduced. When increased to 60mg a week later, the pain went completely away."

   
10

Anonymous (taken for 1 to 6 months) September 16, 2017

1 users found this comment helpful.

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Cymbalta (duloxetine) for Major Depressive Disorder: "Was prescribed Cymbalta 1.5 years ago to treat Major Depressive Disorder. Helped lessen the sadness caused by depression, but also made me numb emotionally. Decided to taper off of Cymbalta, while being advised by my physician, and the withdrawal symptoms were terrible. Currently still on 30mg (down from 120mg) and going to look for easier ways to withdraw. Would not recommend Cymbalta to anyone, as I feel I was doing better before I started the medication, and the withdrawal symptoms aren't worth it."

   
3.0

Zack T (taken for 1 to 2 years) September 9, 2017

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Cymbalta (duloxetine) for Diabetic Peripheral Neuropathy: "I'm a recovering alcoholic of 16 years. I was diagnosed diabetic in 2008 and continued drinking until May 7th 2017. Unfortunately my addiction had caused a lot of damage to my body that I didn't notice while consuming 3-6 gallons of beer a day. In the past if I didn't have a drink I would start to feel pain in my legs so I drank more. Now after the first I weeks and the shakes went away I went to a doctor to get my health checked. After fully disclosing my situation he prescribed gabapentin.. I had a bad skin burring reaction after a few weeks and my legs and feet were like lighting storms of pain. He then prescribed Cymbalta. I was reluctant at first reading all the side effects. But now I take it 2 hours before bed and the pain is gone."

   
8.0

Amoya81 (taken for 1 to 6 months) September 8, 2017

3 users found this comment helpful.

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For Depression: "Worse drug ever!! I am finally weaned off and I can go to the bathroom again, sleep soundly, no more bruising, not tired all the time and the list goes on. You don't know how bad you feel until you go off this drug and feel normal again. The physical side effects are way worse than ant depression!"

Nederland (taken for 5 to 10 years) September 5, 2017

3 users found this comment helpful.

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For Fibromyalgia: "I tried cymbalta before and I gave up two times many side effects, but after trying all others medication like gabapentin, savella, lyrica, pain killers, I decide to give a last chance, and finally work, the first 3 weeks I have all kind of side effects but eventually pass, I started at lower dose of 20 mg once a day then after a month 40 mg a day for two weeks and now I am taking 60 mg once a day. I still experience some moods issues, but my pain went from 10 to 3 and so far I have been on 60 mg for a week, so I hope it keep helping me with the fibromyalgia and anxiety."

   
10

Aslen (taken for 1 to 6 months) September 5, 2017

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For Major Depressive Disorder: "I have depression, anxiety, and ADHD. I tried lexapro, prozac, gabapentin, and lamictal for my depression/anxiety, and none helped at all. I was starting to get discouraged, and I was nervous when my psychiatrist suggested on trying Cymbalta, an SNRI, because I've heard many horror stories about Cymbalta from brain zaps to emergency room visits. But every medication has it's horror stories, and I knew that every person has a different experience, so I gave it a try. And holy moly, this medication saved my life. I feel finally feel like myself again, and thinking about the difference this med has made is making my eyes tear up. I was in such a dark place for so long, and things FINALLY feel okay now. I've been on it for 4 months, 60mg."

   
10

NoGoodUsername (taken for 1 to 6 months) September 4, 2017

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For Anxiety: "This drug is ruining my life. I'm 58 years old and have been tormented by side affects and horrible thoughts. Don't care about anything. If I stop can't handle it. I have tried to get off for last couple of years and has caused my health to decline. I'm 94 pounds now and I just feel like a zombie. Can't even think. Sit for hours on end and can't move. Don't take this drug. It will ruin your life and change you to someone who doesn't care about anything. Don't take this drug."

   
1.0

Tina464 September 1, 2017

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For Pain: "I had Shingles in March and was given two meds - one was an antiviral and the other for pain. The pain pill they gave me didn't mix with my meds. I went without the pain med. Then the beginning of April the pain came. It got worse and worse. April, May, June, July ever increasing pain around the shingles area. Went to my family doctor in Jul and she prescribed Doloxtine 30mg. Well I read the pill first. I read and wanted to avoid ALL Side affects. So I continued without the pill and took tramadol and a local ointment. The pain was constant and intense. Aug 3 back to my family Doc. She insisted I try the Doloxtine about 3 days later almost no pain. Yesterday she increased it to 60mg. So far so good, I shouldn't be so stubborn."

   
8.0

JAM51 August 30, 2017

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Cymbalta (duloxetine) for Chronic Pain: "I suffer from chronic pain, depression and anxiety for the past 10 years and I'm 30. Football ruined my life, but cymbalta has made it worse. Not only did I NOT receive any benefit from cymbalta but I gave it the a serious 2 month try and I'm not spending 90% of my time withdrawing from it. I cannot imagine if I was on this a year, let alone ten. If this medicine helps you, I would weigh the benefits seriously- because either you're going to the grave with this medicine or you're going to have to feel the "benefits" of coming off of this poison. Beware.. because no doctor will tell you these things. Worse than 2 years of clonazepam, alcohol, or opiates... no joke. Hope this helps someone!"

   
1.0

Adub0614 (taken for 1 to 6 months) August 29, 2017

15 users found this comment helpful.

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Cymbalta (duloxetine) for Fibromyalgia: "I have tried amitriptiline, citalopram Paxil Gabapentin and now Cymbalta I sure have noticed a big difference thank goodness I was ready to give up."

   
10

Budgee (taken for 1 to 6 months) August 29, 2017

10 users found this comment helpful.

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Cymbalta (duloxetine) for Fibromyalgia: "I have been suffering for years to the point I could not walk to the parking lot without having pain throughout my whole body. My legs would go numb to the point I couldn't walk and had to sit til I can feel my legs again. Since taken cymbalta I've been able to do normal house work exercise a little. And wake up and get out the bed without pain. It's the worst feeling in the world to wake up everyday and every part of your body hurts. I'm on 30 mg and I have been feeling like a normal person again I love living again."

Janess August 24, 2017

4 users found this comment helpful.

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "Cymbalta seems to be working great for me. I had been on two others Lexapro and Zoloft just prior. One made me feel happy but had bad side effects and the other stopped the panic and anxiety but left me feeling depressed/unhappy. I was not real hopeful going on this as I thought I needed more serotonin in my body verses just levelling out what I had, I was happy to find out that it seems to help a lot. No panic and anxiety and I actually feel like getting up and doing something rather than laying around and I have lost 8 pounds! I take 20mg and that seems to be all I need. Overall I am happy with it."

Windee (taken for 1 to 6 months) August 22, 2017

6 users found this comment helpful.

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Cymbalta (duloxetine) for Chronic Pain: "This is the worst drug ever put out. I'm 70 and it has ruined my life when weaned off it has nearly killed me. I have been over a year of withdrawal and still going. They should be stopped from selling this and tell everyone you know to never be put on this crap - it will ruin your life"

Pus August 21, 2017

11 users found this comment helpful.

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Cymbalta (duloxetine) for Fibromyalgia: "I was on Cymbalta for fibromyalgia and the medication did not work for me. I did have a change in mood. One thing they do NOT tell you is getting off the medication is a terrible experience. For two weeks I was vomiting about three times a day. My anger was uncontrollable and I had very bad brain zaps. I did tapper like the Dr recommended and I was still sick. This lasted a month after my last tapper dose. I was never a depressed person but my husband almost had to take me to the ER because I was so bad. Don't take this medication it is not worth the effects."

Hamrick August 21, 2017

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Cymbalta (duloxetine) for Depression: "I was put on this for a while. It made me very depressed, anxious and withdrawn. It was only when my friends told me how bad I was that I realised I was having a real "breakdown" on it. I went to see my doctor who changed me to Sertraline which suits me a lot better. I was depressed before I took Duloxetine but I went in to a very dark place that I had trouble getting out off. We are all different and different medication suit different people."

   
2.0

Tina50 August 18, 2017

12 users found this comment helpful.

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For Anxiety: "Awful!!! Caused my anxiety to go into massive overdrive to the point my entire body was shivering. I did fall asleep at night because I was exhausted from being on edge all day. I put on 15 lbs since I started taking it 3 months ago. They are like speed pills which causes the excessive anxiety. So glad I'm off of them now. Definitely not for me! (Bipolar-PTSD-OCD-Anxiety) this medicine was added to my daily Lamictal 150mg"

   
2.0

NurseBetty88 August 17, 2017

2 users found this comment helpful.

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "To the gentleman whose doctor switched him from Klonopin to Cymbalta: The reason you are suffering from severe anxiety is that you were taken off a Benzodiazepine too quickly instead of having been TAPERED off the drug. Cymbalta is no substitute for Klonopin. Your doctor needs to go back to med school! I've been taking 60 mg of Cymbalta since 2009, after my husband committed suicide. It has helped me a lot with depression and anxiety, but I'm finding that my anxiety has recently increased because my new husband has lung cancer. I was put on 90 mg of Cymbalta recently, and I'm hoping that the higher dose will decrease, and not increase, my anxiety levels."

   
10

GenieP August 15, 2017

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Cymbalta (duloxetine) for Chronic Pain: "I have had three back surgeries the latest was back fusion I now suffer from nerve pain especially in my right thigh and knee At times I can hardly walk due to the pain and weakness in my leg Xrays and MRI show the fusion is in the correct position but the Specialist have said I may always have this nerve pain They prescribed Cymbalta and oh what a calamity I only took this medication for 3 days and that was 3 too many I was not warned about possible side effects these are numerous Massive increase in pain Massive increase in weakness in the leg (had to use a walker) Chest pain Headaches Nausea Stomach pain Mood swings like anger suicidal thoughts Nightmares Hot and cold flushes Sweating for no reason list goes on"

   
2.0

austmanice (taken for less than 1 month) August 14, 2017

12 users found this comment helpful.

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For Depression: "I began taking this in April after a suicidal episode. I started at 30mg and noticed the effects immediately. I suffer from social anxiety and clinical depression. Constant worrying and panic attacks. The first thing I noticed was that it became easier to let go of worrying thoughts. e.g. if I embarrassed myself usually I'd ruminate until I became depressed, once I started duloxetine the bad thoughts were out of my mind almost as soon as they came. This made life a lot easier for me, day by day my symptoms disappeared. It is now August and I am on 120mg the maximum dose. Its wearing off as my mood is starting to slip, but I can honestly 100% say that for the past 5 months I have been cured. Duloxetine was the best thing to ever happen to me."

   
10

A girl with depression August 13, 2017

5 users found this comment helpful.

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "Hey everyone trying cymbalta, This drug has calmed me down and lightened me up. When someone asks me how I'm doing, I can honestly say , good ! I use to be intense and I thought about suicide a lot and spent many hours in bed trying to escape from reality . I hated small talk and saw it as phoney and awkward and an act I put on just to come across as average ; like the average happy person . Nope . That was not me . I was tormented by anxiety and depression and dark thoughts. Cymbalta is a good drug. Hope it works for you. I started at approx 5 mg, then 10, 20 and now 30mg. Low dose I know but effective. I would open the capsule and measure a somewhat close enough dose to what I could handle . Give it a good 3 months to work!!"

Sage123 (taken for 1 to 6 months) August 12, 2017

7 users found this comment helpful.

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Cymbalta (duloxetine) for Depression: "I've been taking Cymbalta for depression for two and a half years. My doctor titrated me up to 120mg. I was at 120mg for over two and a half years and almost constantly I was severely depressed, severe anxiety, some paranoia, no energy, over reaction, self harm, extreme anger, just to name a few. That's not to say I do have some of those problems normally, but not as severe or as constant. So Cymbalta was overlooked as a cause to my worsening issues. Two weeks ago I was admitted into an inpatient hospital to basically save my life. While I was in there I was abruptly taken off, then titrated up to 60mg. I'm a totally different person now. I did a complete 180°. I can't believe what a difference it makes being on the right dose."

   
5.0

ShaeFox (taken for 2 to 5 years) August 10, 2017

11 users found this comment helpful.

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Cymbalta (duloxetine) for Diabetic Peripheral Neuropathy: "I have taken 60mg for 20 years. Three weeks ago my Dr. dropped the dosage to 30 mg. I had some hateful and days of crying. Now that passed but my feet and legs and lower back hurt so bad I can barely walk. Is this normal and would it stop if I took 60 again."

   
9.0

Billiejeanhampton (taken for 10 years or more) August 7, 2017

2 users found this comment helpful.

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For Depression: "I have PTSD. Depression. Anxiety. Bone pain. I'm not one for pills, in the past I've been used as a Guinea pig for a plethora of meds and I've also self medicated before PTSD was diagnosed. I've several issues from long term injuries including broken leg and multiple internal injuries from stabbing. I was on sertraline for a year while on diazepam and dehydracodeine for pain relief, they made me a shadow of myself. I found a new doctor who recognised instantly my TBI, PTSD ISSUES etc. He prescribed me duloxetine 30mg, a month later I've felt nothing, if anything I was doing less, still in pain and still in a dark place mentally. I revisited him last week to review, he upped my dose to 60mg and the difference is unbelievable! Pain down, depression gone!Anxiety all time low!✅ "

   
9.0

John. (taken for 1 to 6 months) August 5, 2017

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