Skip to Content

User Reviews for Duloxetine

Also known as: Cymbalta, Irenka

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Condition Avg. Ratings Reviews Compare
Pain
7.4
   
72 reviews 1111 medications
Osteoarthritis
7.1
   
27 reviews 351 medications
Anxiety
6.8
   
237 reviews 56 medications
Bipolar Disorder
6.8
   
33 reviews 30 medications
Generalized Anxiety Disorder
6.7
   
105 reviews 7 medications
Depression
6.6
   
532 reviews 81 medications
Fibromyalgia
6.5
   
234 reviews 20 medications
Diabetic Peripheral Neuropathy
6.5
   
37 reviews 41 medications
Major Depressive Disorder
6.1
   
65 reviews 46 medications
Small Fiber Neuropathy
6.0
   
1 review 0 medications
Peripheral Neuropathy
5.9
   
30 reviews 6 medications
Chronic Pain
5.8
   
124 reviews 108 medications
Back Pain
5.8
   
42 reviews 178 medications
Chronic Fatigue Syndrome
5.7
   
5 reviews 2 medications
Persistent Depressive Disorder
5.5
   
2 reviews 3 medications
Hot Flashes
5.4
   
12 reviews 17 medications
Urinary Incontinence
4.4
   
4 reviews 49 medications
Summary of Duloxetine reviews 6.5 1,562 reviews

Reviews for Duloxetine

Cymbalta (duloxetine) for Major Depressive Disorder: "It did okay for my depression, reduced my headaches, improved my concentration and my sleep and reduced my anxiety, but it did almost nothing for social anxiety. I switched from Cymbalta to Effexor and I immediately found that Effexor was far superior in almost everything.I would recommend Cymbalta as your second choice SNRI, if Effexor won’t work for you."

   
5.0

Nicolas (taken for 6 months to 1 year) April 9, 2019

0 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Anxiety: "I started on 30 mgs a day and stopped on the 5th day. I felt so nauseous and intestinally challenged. The drug also caused my heart to go into afib / aflutter with moderate tachycardia. As soon as I told the Doctor what was happening he had me stop immediately. Now I am waiting to see a cardiologist to assess the arrhythmia situation. I know the literature says that my side affects are rare, but it happened to me."

   
1.0

Bryan (taken for less than 1 month) April 9, 2019

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Major Depressive Disorder: "I started taking cymbalta 60 mg daily in 2010 after taking natural therapies that just didn’t work. I had severe depression and anxiety. First started on 30mg first month, then increased to 60mg. Side effects were yawning, tight jaw. But I found the Cymbalta that had helped me immensely, with my dark thoughts, sadness, hopelessness had disappeared. I did try going off it a few years ago very gradually, as I thought I was well again, but everyday was such an effort, seratonin was so low. Depression returned and I just thought this is crazy, go back on it. I have so many friends that are so anti prescribed drugs. So I just don’t enter into discussions as it only upsets me because I need this medication. I find I’m happy, healthy in mind. My libido is quite low but I’m active in sport and the community which helps me."

   
10

Missymoo April 7, 2019

5 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Chronic Pain: "Cymbalta was very helpful for my fibromyalgia pain. My pain was reduced by 80%. It was also very helpful in reducing my anxiety. There was one side effect I could not tolerate any longer after 3 years, PROFUSE head sweating. I cold be sitting in an air conditioned house and break out in a horrible sweat. Once I realized it was the Cymbalta I had my doctor wean me off. Please don't stop this medication cold turkey, that can be dangerous."

   
8.0

Nana (taken for 2 to 5 years) April 4, 2019

3 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Hot Flashes: "Began duloxetine for poor sleep and chronic back pain— cannot say that I had depression but have found mood improved. I am very delighted and surprised to find that back pain greatly improved and I was able to go off my HRT without the vasomotor issues returning or insomnia that I have had in past. Only down side is dry mouth and the sexual side effects — working through these. So far so good."

   
9.0

Gramma (taken for less than 1 month) April 4, 2019

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Major Depressive Disorder: "Tried this back in 2006, it was the only time I've ever had suicidal thoughts. After two weeks I was not myself, being temperamental , bad attitude, waking up mad. I quit taking it and felt myself at least return to how I was before. An old girlfriend said her ex husband tried to kill himself on cymbalta and after some research. Cymalta has a black box warning which is about the increase in suicidal thoughts. This stuff needs to be taken with caution and whoever takes this needs people around them who know about the increased risks."

   
1.0

Alucard146 (taken for less than 1 month) March 30, 2019

4 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Depression: "It worked for depression back pain and migraines. But I threw up constantly, and couldn’t keep anything down at all. It always came back out one way or the other. At one point I started getting stomach pains from throwing up so much. My throat is sore and a little swollen now too from it. And I would feel numb sometimes and “off” emotionally. Never felt so bad. Got taken off of it, and the withdrawal symptoms are awful too. Wouldn’t recommend it at all. It’s just not worth it."

   
2.0

Me (taken for less than 1 month) March 29, 2019

4 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Chronic Pain: "Took drug for over six years. Couldn't say it was helping for pain or depression as how would you know how you would feel if you were not taking it? You have nothing to compare it to. I've been titrating off this drug for two months. I have every side effect listed. This is horrible. Please research before taking."

   
1.0

teenerweener (taken for 5 to 10 years) March 25, 2019

3 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Anxiety: "Cymbalta saved my life, I went from a severe agoraphobic with stomach pain, heart palpitations, hyperventilation and insane blood pressure issues on a daily basis to my fully functional self again. I was extremely dissociative before taking this drug and never left my bed because my panic disorder was so debilitating. After about a week on cymbalta, I was up and moving around in the world. Several months later, I'm now in college with a new job and excelling. I've had 2 panic attacks in the last 6 months. My only complaint is that it makes me very tired, but this is easily remedied by taking it in the evening instead of the morning."

   
9.0

Georgia (taken for 6 months to 1 year) March 25, 2019

8 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Anxiety: "I take 20mg of duloxetine because I’m super sensitive to any SSRI or SNRI, everybody’s different I felt quite nauseous and dizzy for the first 2/3 days and now it’s been 2 weeks now and I feel like my old self. I suffer with PTSD and I used to have crippling panic attacks where I got to I couldn't leave the house at all. Now I can get on a bus and do my normal things, still with anxiety but I am a lot better than I was and hopefully one day I won’t need this med to aid me. This is the first med I’ve kept taken as well with minimal side effects."

   
9.0

H March 24, 2019

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Depression: "Hi, I am at the end of week one 30mg Cymbalta, and it is like a brand new me.. although today I have hit a little bit of a low, I am so much better. Cymbalta literally has saved my life and my marriage PRAISE GOD!!!!! I am looking forward to each day and know with time all will level out. No more extreme lows with suicidal thoughts, sleeping all day long, just wanting life to end. I wished I would have let my pride go a long time ago & told my doctor I needed help. Wednesday is my birthday and I am looking forward to spending it with my husband... Yay!!! 44 and hopeful for the future."

   
10

Joyful1975 (taken for less than 1 month) March 18, 2019

24 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Anxiety: "Cymbalta worked to saved my life after perimenopause made my already existent depression increase tenfold. My depression was so dark I felt like I was being held down in a dark abyss. If I didn't seek medical help, I honestly believe I would have taken my own life. 60mg of Cymbalta daily and I could get out of bed, live my life, and function as a loving single parent who could provide for her family. Now, ten years later I will discuss the increasing anxiety I am feeling. Will my Cymbalta dosage increase. I don't know. But I do know for those 10 years I was not just surviving I was living. Thanks to Cymbalta"

   
10

Missy (taken for 10 years or more) March 17, 2019

22 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Back Pain: "At first duloxetine was a God-send, all pain went and I could get back to work and be normal again. It did have a side-effect for me that I couldn't stay asleep so was prescribed Amitriptyline. I noticed a definite decrease in libido to the point where I had NO sexual thoughts at all. I was made aware that I had started to withdraw from social situations and friends and could see no reason why this was the case. After reading reviews I realise I am not the only person affected this way. I am coming off them but having problems, too many to mention I am now almost 8 months down the line, I seem to be pain free and haven't taken a tablet for over 10 days, I don't feel back to normal yet but feel a bit better but feel as though there is a way to go yet. DO YOUR RESEARCH - DO NOT TAKE THIS MEDICATION UNLESS ALL ELSE HAS FAILED. I will definitely source other options if/when my back issues return."

Getting better everyday (taken for 2 to 5 years) March 10, 2019

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Pain: "I've been on Duloxetine about 5 years (@ 60 mg/day), and want to encourage people considering trying it not to be scared off by negative reviews. I do believe the negative reviews are (generally) legitimate, and that a lot of people have had negative experiences. Their voices are also critical (as are all patient's) in helping to create awareness. But I believe the experience most people have with duloxetine is not dramatic. It either helps (sometimes a lot; other times just enough to keep taking), or doesn't. It helped significantly in my case, making my pain bearable, allowing mostly-normal day-to-day activities. I did have initial drowsiness (which went away in 10 days - 2 weeks), and nausea (still have occasionally), dizziness & balance issues (still remain, but not major). Don't be afraid to try Duloxetine, it presents a reasonably good chance to provide you with meaningful relief. Best of luck:-)"

   
8.0

Bluefish321 (taken for 2 to 5 years) March 8, 2019

3 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Depression: "Cymbalta helped me get through a rough patch in my life. I am grateful for how it allowed me to cope with my sibling's passing. I was on 60mg and recently decided it was time to move on and discontinue medication. I decreased dosage every two weeks by 10mg, then weekly by 5mg (taking out one small pill of the 12 pills in the capsule). Please talk to your doctor if you wish to taper off the drug, but this method worked for me. I was terrified of withdrawals based on the horror stories I read, but I had almost no withdrawal symptoms. The sexual side effect of the drug was a real bummer, and the only negative of my experience."

   
8.0

TP (taken for 1 to 2 years) March 8, 2019

14 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Osteoarthritis: "I was given Cymbalta 60mg for arthritis pain primarily and insomnia secondary. It had been recommended by both my oncologist and PCP. I felt awful the 5 days I took it. While there was a slight reduction in pain from a 4 to 3, I couldn’t eat. I woke up from restless sleep vomiting; I could have aspirated. I stopped immediately and had no side effects from doing so. The nausea was unbearable, and my anti-nausea meds were counter-indicated. Horrible experience. I gave a 2 rather than 1 due to slight pain reduction. I saw no improvement in sleep."

   
2.0

Astyanax (taken for less than 1 month) March 3, 2019

1 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Fibromyalgia: "When I began this med for fibromyalgia I thought it was going to work out for me. I felt good enough to start swimming (the only exercise that doesn't hurt me) after a week of being on Cymbalta. I couldn't take the pill on an empty stomach--stomach ache, I couldn't take the pill at night--insomnia, and I had to take it with lunch in order to not have adverse affects. I felt like my pain stopped lessening after 6ish months of 60mgs a day so I stopped taking it. Another bad side effect was the total destruction of my sex drive. When I stopped taking it, my doctor told me to slowly ween off of it due to terrible side effects, but I had already stopped taking it before I saw her, and I didn't have any adverse effects of quitting cold turkey."

dawn19825 (taken for 6 months to 1 year) March 2, 2019

36 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Anxiety: "I have tried cymbalta on 2 different occasions with worsening conditions. It is like all the other SSRI drugs. This medication caused me to become stiff and rigid. I have suffered from racing thoughts most of my life. My doctor finally put me back on benzodiazepines and I am like a new person. Myself again."

   
2.0

Jax103 (taken for 1 to 6 months) February 23, 2019

6 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Depression: "I am on day 3 and I am feeling better than I have in years. My Mom died in 2016 from breast cancer and my brother died in 2017 in a motor cycle wreck. My brother in law had a heart attack in 2018 (they bypassed him and he’s ok!)and his mom passed away from brain cancer this year. Also a family friend just the other day. I have been convincing myself I could do this without help but it became to much. (I have a teenage daughter) :) I decided I had to try something. I know it’s only 3 days but if I feel this good now I know it will get better! Thank you Cymbalta!!"

   
10

Fab4 February 16, 2019

14 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Anxiety: "I have been doing 30mg of cymbalta for the past four years and it was working so we'll.. recently I have had increased stress which is not helping my anxiety. I am starting 60g dosage tonight. I think my body has just gotten tolerant of the 30mg and I need in increase."

   
8.0

Muffin (taken for 2 to 5 years) February 14, 2019

9 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Depression: "So I was on Lexapro for 5 years it stopped working. Doc suggested Cymbalta. I was scared to try with all the bad reviews. But I started on 30 mg for 2 weeks. Then up to 60 mg after 2 weeks. Side effects were dry mouth, nausea, dizzy. But side effects have gotten better and this is working. No more crying spells, moodiness. Also it has helped my back and neck pain."

   
10

Mary (taken for less than 1 month) February 12, 2019

12 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Anxiety: "I've had GAD pretty much all my life but developed increasing depression and withdrawal from social activities. Finally I bit the bullet and told my doctor. He started me on duloxetine, 30 mg with the warnings about weight gain and sexual dysfunction and commented we could increase to 60 mg in three or four weeks if needed. Never needed the increase - 30mg is perfect. I have gained 4 or 5 pounds. I did notice the sexual dysfunction (loss of interest and difficulty "finishing" at first so I would hold my meds a day or two before bath and treat night which worked fine. Pretty much back to normal in that regard. The best thing is I can get more than one or two errands completed now. I call my pills "do lots of things" now!"

   
9.0

Pursuit (taken for 6 months to 1 year) February 11, 2019

10 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

For Depression: "Duloxitine was prescribed for me by my psychiatrist. I have suffered depression on and off for 25 year's. 6 year's ago after having my son switched from citalopram and thought it's pretty good. That was until I got used to the 30mg I was on and had to increase to 60mg, then 90mg and now I'm on 120mg. Sometimes I think I can't be without it then other time's I think not a chance that they working properly still. I was told they are a dual controlled medication which act as a mood lifter and motivator. If I'm honest I keep a diary of how I feel every day, and I have more bad days than good. I do have a lot going on in my life, which I think doesn't help. I've tried coming off a few time's but I hate the dizzy feeling from the side effect which leads to really bad feelings."

   
5.0

Hot potato (taken for 5 to 10 years) February 5, 2019

2 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Fibromyalgia: "I finally decided to try this medication after being sick and tired of being in constant pain, especially at night. I've had fibromyalgia for 20 years and in the past 10 years I've been treating it on an acute basis with Flexeril 20mg and Tramadol 50mg as needed. Cymbalta has been a game changer for me! I would like to mention that I've also worked hard to maintain a steady weight for the past 20 years which as a health care professional myself, I knew this was a crucial component in chronic pain management. I believe this helped me not to rely on medications on a daily basis. However, now that I am on Cymbalta I realize how much pain I truly was in on a daily basis. The only side effects I have suffered thus far is mild nausea and dry mouth which gets better day by day. It's only been a week and my aches and pains are completely gone! I'm hoping that the sweating side effect doesn't kick in."

   
9.0

MB (taken for less than 1 month) January 31, 2019

11 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Cymbalta (duloxetine) for Depression: "It really gave me my life back. From crying and having panic attacks to kayaking and biking with my friends. Amazing product."

   
10

MC (taken for less than 1 month) January 30, 2019

18 users found this comment helpful.
Did you?   Yes   No   |   Report inappropriate

Hide