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User Reviews for Duloxetine

Also known as: Cymbalta, Irenka

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Duloxetine.

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Condition DownUp Reviews Compare Avg. Ratings DownUp
Persistent Depressive Disorder 1 reviews 3 medications
   
10
Pain 64 reviews 1118 medications
   
7.4
Anxiety 173 reviews 56 medications
   
7.1
Osteoarthritis 23 reviews 350 medications
   
7.0
Bipolar Disorder 32 reviews 28 medications
   
6.7
Generalized Anxiety Disorder 85 reviews 7 medications
   
6.7
Hot Flashes 9 reviews 19 medications
   
6.7
Depression 458 reviews 79 medications
   
6.6
Diabetic Peripheral Neuropathy 31 reviews 40 medications
   
6.6
Fibromyalgia 196 reviews 20 medications
   
6.5
Major Depressive Disorder 47 reviews 46 medications
   
6.4
Back Pain 27 reviews 178 medications
   
6.4
Peripheral Neuropathy 26 reviews 6 medications
   
6.3
Chronic Pain 95 reviews 108 medications
   
6.1
Small Fiber Neuropathy 1 reviews 0 medications
   
6.0
Chronic Fatigue Syndrome 5 reviews 2 medications
   
5.7
Urinary Incontinence 4 reviews 49 medications
   
4.4
Summary of Duloxetine reviews 1277 reviews 6.6

Reviews for Duloxetine

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Cymbalta (duloxetine) for Anxiety: "Go figure, the only one that works is the most expensive lol.. I have had not one side effect it works wonderfully for me. I used clonazepam with it for awhile and finally decided to just do the Cymbalta. I helps me with my PTSD which was caused by a severe car accident so I love it as I no longer have to experiment with a hundred different types."

Anonymous (taken for 1 to 6 months) July 25, 2017

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For Osteoarthritis: "I never have had such a love/hate relationship with any drug. Started taking 2 months ago and experienced immediate side effects from throat all the way to my intestines along with headache. Side effects have decreased and I've tried going to 60 mg that lasted no more than 5 days before back to 30 mg. I keep waffling between continuing it or stopping it. Only happy days are those I don't take it. Positives are it decreased my osteoarthritis and neuropathy pain and reduced swelling of ankles. Side effects intensity changes often. This is really the drug from hell!"

Aunt Annie (taken for 1 to 6 months) July 24, 2017

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Cymbalta (duloxetine) for Depression: "Very effective worked immediately"

Jodie c July 24, 2017

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Cymbalta (duloxetine) for Anxiety: "Was on 40 mg of Cymbalta for 6.5 months, and it gave me massive high blood pressure! Since my BP remained elevated for so long even with BP meds, I became too frightened to continue taking any Cymbalta while waiting to see my psychiatrist for a revision. I know you are supposed to taper off, but I stopped completely 5 days ago. For days 1-3, I had symptoms of withdrawal with increased sweating and what felt like the blood coursing through me was pulsating. Also, arms a bit shaky when using hands. Day 4, first day to go out and run errands. The blood coursing feeling changed to a sort of high, with increased food cravings for 24 hours. Day 5, blood coursing feeling has mostly subsided, as well as the hunger cravings. Feeling good today."

High BP (taken for 6 months to 1 year) July 22, 2017

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For Anxiety: "I was put on duloxetine to enhance my citilopram performance. It had absolutely no effect in helping my anxiety. I asked my doctor ( originally ) if she could increase my dosage of citalopram. Adding duloxetine to my anxiety meds, was not working for me."

PN56 (taken for 1 to 6 months) July 20, 2017

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For Peripheral Neuropathy: "Started taking this drug about three weeks ago because of the neuropathy in my feet and legs. I already take three different antidepressants for bipolar II I found that this did lift my mood a little bit more but I haven't seen much improvement in the neuropathy. I am taking 60 mg once a day. Major side effects I am struggling with are hot flashes and disrupted sleep at night. Has has anyone else had the side effects and did they go away?"

Massgardener (taken for less than 1 month) July 20, 2017

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Cymbalta (duloxetine) for Osteoarthritis: "I've been in constant pain from osteoarthritis with some fibromyalgia on top of it for about two years and began taking cymbalta about 6+ weeks ago. I've been pain free for a month now with no need for any painkillers (I was taking a vicoden and tramadol every day during that time). Truly a miraculous recovery. Interestingly my doctor told me that his wife who had bad osteoarthritis pain had the same result from the cymbalta. Hope that it continues!"

   
10

Daisypop July 19, 2017

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For Depression: "I'm not getting much relief with my depression. I wonder if there's another medication that could be used along with Duloxetine (Cymbalta) to help."

Poodle Lady (taken for 5 to 10 years) July 16, 2017

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Cymbalta (duloxetine) for Fibromyalgia: "I've been taking it for less than a month and I already want to stop. I would rather be in pain than be how I am with this medicine. It makes me foggy and extremely tired, and depression symptoms I haven't had in months are coming back. I can barely do anything because all I feel like doing is sleeping. My fibro pain isn't horrible anymore, but this is worse. I'm going to stop now while I'm still on 20mg before weaning off becomes harder."

   
3.0

mlleindrani July 14, 2017

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Cymbalta (duloxetine) for Anxiety: "I Just started on 30mg today, I had to come off of Prozac 20mg after five days, because it made my anxiety worse, and no appetite and my stomach hurt, and stayed in the bathroom. I use to be on Cymbalta and it was great, I came off of it because I thought I could deal with my menopause, and nope, it got bad again with anxiety. I hope Cymbalta helps me."

Cjene July 13, 2017

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Cymbalta (duloxetine) for Chronic Pain: "I have not actually taken this yet. My prescription will be ready by tomorrow. I'm scared, depressed, hopeful and in pain.... I hope I have good stories to share like the positive comments on here. I worry I'm going to be like the others."

JuicyK81 July 11, 2017

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For Peripheral Neuropathy: "I got breast cancer mets in my bones (mainly spine) in 2010 and had chemo. I recently was diagnosed with chemo induced peripheral neuropathy CIPN. I'm on Lyrica 250mg/day, which helps a bit. They tried all the anti-epileptics and most of the amnitriptiline family and gave up. My psychologist suggested Duloxetine. I've been on it two months and I'm loving it! The lightning strikes have abated but I still have a little burning, etc and still drop everything I pick up, bit without this drug the pain was intolerable! It has even helped with my cancer pain. It has caused a bit of fogginess, occasional bouts of double vision and ringing in the ears - BUT that's nothing compared to the side effects I got from all the other concoctions. Love it."

Cheryl2017 July 8, 2017

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For Depression: "For some reason my spouse and I were both givne this last month when prescription was renewed. I have been on this medication for 10 years plus. Within two weeks I felt headaches, severe irritability and depression. It was horrible. I even took 120 mgs one day and it worsened. Thank heaven this month was back to normal. Within 3 days I am feeling better. Btw my spouse feels the same way."

Jodi1202119 (taken for less than 1 month) July 6, 2017

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Cymbalta (duloxetine) for Osteoarthritis: "I started taking this med six days ago to treat neuropathy pain in my feet and lower legs. It, like gabapentin that I was taking before this, is giving me severe arthritis pain in my hands and knees, which I did not have before. I will discontinue the use today. It stopped the neuropathic pain but is crippling me in other ways. I will go back to treatments with NSAIDS and acetaminophen."

   
3.0

Justajo (taken for less than 1 month) July 2, 2017

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Cymbalta (duloxetine) for Depression: "Ok so I'm a 19y/o female and, After a month and a half of super minor side effects (groggy, dizzy, no appetite) cymbalta started to work really well, however about a couple months ago I began experiencing mood swings more and more gradually. Now I have days where I'm in a completely crabby mood (I don't want to do anything), or I'm in an ok mood (I'll go out and try to do a couple of things to build confidence), or I'm totally pissy and mean all day and I cry and flip out. (like literally cry and like threaten to leave him for nothing) My poor boyfriend who doesn't even understand the medicine (who tries to because he respects my choices) I plan on changing my medicine my next doctor's visit cuz the mood swings are making it hard to get a job."

   
6.0

Meghan k (taken for 1 to 6 months) June 30, 2017

4 users found this comment helpful.

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Cymbalta (duloxetine) for Depression: "Had panic attacks and major depression. This medication changed my life for the better. Been on this medication for almost a year. Takes about 3 months to feel the full effect. If the dose is too strong you may feel worse. Its trial and error."

   
10

Shannon262 June 28, 2017

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Cymbalta (duloxetine) for Depression: "Just took it at its smallest available dose this past week. I was replacing my Zoloft because I felt that my depression is more of a reaction to my anxiety, so my doc put me on this which is known to treat both, unlike Zoloft which only treats depression. I have yet to experience any bad side effects like many do in the beginning, and if anything it actually treated the side effects of getting off Zoloft, like nerve tingliness. It gives me an overall sense of calm, and unlike other anxiety meds, it doesn't sacrifice by concentration and memory which is very important since I'm a full time student. It calmed my anxiety and allowed me to sleep, which in result, I don't feel depression. A+ on this medication so far."

   
10

Kay F. (taken for less than 1 month) June 23, 2017

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Cymbalta (duloxetine) for Depression: "This drug has changed my life. Before taking Cymbalta I was depressed, anxious and borderline suicidal. Within a few weeks of my first dose (60mg) I noticed that I was more outgoing, friendly and that my mood has significantly improved. Although I experience some sexual side effects, the drug has been incredible on the whole. I'd highly recommend it."

   
9.0

houdini95 (taken for 6 months to 1 year) June 21, 2017

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Cymbalta (duloxetine) for Anxiety: "I'm pretty sure that I don't suit this medication. The first three weeks were absolute torture with blurred vision, headaches, nausea, and no energy. After that time the medicine did seem to help my anxiety and depression. However, after three months the side effects came back worse than the first three weeks. I went to my doctor and asked to switch medications immediately. Coming off of the Cymbalta was the worst experience of my life. At one point I had uncontrollable shaking and muscle movements. I couldn't even concentrate enough to go to the kitchen and make a sandwich. I know this drug works for many people, but for myself it was like taking poison."

   
2.0

Spencer H (taken for 1 to 6 months) June 19, 2017

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Cymbalta (duloxetine) for Depression: "It works one of the few antidepressants that I can take that doesn't have any side effects I can notice. Other antidepressants in other families, I.e. SSRI's I know I cannot take due to the side effects. With cymbalta, I don't feel any side effects, and I seem to function alright. I know it works because off it, I can't pull it together and am in bed most of the time, so it works. I give it a B+ because I can't take it at its highest dose without getting too overstimulated. I take it at 30mg."

Anonymous June 15, 2017

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Cymbalta (duloxetine) for Depression: "It alleviates my depression. But I have some headache, I am not sure if it is caused by the drug"

   
9.0

caden byran (taken for 6 months to 1 year) June 12, 2017

8 users found this comment helpful.

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Cymbalta (duloxetine) for Fibromyalgia: "I did not notice a change while taking this med. I still took it for 2 years even though it was not effective. The reason I continued this med was because everything me and my Dr tried to get me off the med, it did not work. Finally after 2 years. I was able to stop taking it by starting prozac the next day of my last dose of cymbalta. I took the prozac for 10 days with no side effects and then I stopped the prozac. I am finally free of that prison."

   
2.0

Medicman4tn (taken for 2 to 5 years) June 11, 2017

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Cymbalta (duloxetine) for Anxiety: "It's amazing. Zero side effects. I feel "Normal". These reviews scared me but my Dr encouraged me to try for myself and see. Lexapro put 10 kilos on me. Edeonax made me the sickest I have ever been in my life and was a bloody nightmare. After that ordeal I was so scared to take Cymbalta. My energy is amazing now. Anxiety, panic attacks and social anxiety feel mild but manageable- like I have a chance."

   
10

Sharing (taken for less than 1 month) June 8, 2017

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For Depression: "This worked for a while, but not a long time"

shouwang2007 (taken for 1 to 6 months) June 7, 2017

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "I personally didn't like this medication as it made me so sick I couldn't eat lost weight and generally felt weak due lack of energy from not eating. Although my GP told me this was a rare occurrence as the side effects generally stop after a couple of days after weeks they didn't. Still looking for a medication that suits me personally. Glad it has been effective so many others"

   
1.0

Muchelle (taken for less than 1 month) June 3, 2017

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