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User Reviews for Duloxetine

Also known as: Cymbalta, Irenka

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.

Learn more about Duloxetine.

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Condition DownUp Reviews Compare Avg. Ratings DownUp
Persistent Depressive Disorder 1 reviews 3 medications
   
10
Pain 64 reviews 1119 medications
   
7.4
Anxiety 167 reviews 56 medications
   
7.1
Osteoarthritis 20 reviews 350 medications
   
7.1
Generalized Anxiety Disorder 83 reviews 7 medications
   
6.8
Bipolar Disorder 32 reviews 28 medications
   
6.7
Hot Flashes 9 reviews 19 medications
   
6.7
Depression 448 reviews 79 medications
   
6.6
Diabetic Peripheral Neuropathy 31 reviews 40 medications
   
6.6
Fibromyalgia 194 reviews 20 medications
   
6.5
Major Depressive Disorder 46 reviews 46 medications
   
6.4
Back Pain 27 reviews 178 medications
   
6.4
Peripheral Neuropathy 24 reviews 6 medications
   
6.3
Chronic Pain 93 reviews 113 medications
   
6.0
Small Fiber Neuropathy 1 reviews 0 medications
   
6.0
Chronic Fatigue Syndrome 5 reviews 2 medications
   
5.7
Urinary Incontinence 4 reviews 49 medications
   
4.4
Summary of Duloxetine reviews 1249 reviews 6.6

Reviews for Duloxetine

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Cymbalta (duloxetine) for Fibromyalgia: "I took Cymbalta for 6 years after my house burned down, my husband was diagnosed with cancer, he lived 8 months. I was diagnosed with fibromyalgia and severe depression. It worked with minimal side effects. I felt like myself 3 days after starting it. I was in a good place 8 yrs. I weened off and stopped taking it. 3 years later I had a massive stroke and slowly began to feel more and more depressed. I was suicidal in Jan. 2016. I asked a new Dr. to put me back on it. I felt better in only 36 hours. It was amazing how it changed my thinking. My back pain, suicidal thoughts and anxiety had all but disappeared. I would recommend Cymbalta to anyone with any of these symptoms. Everyone is different and if my not work for you. I'm still taking it."

MamaKat_55 (taken for 10 years or more) May 18, 2017

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Cymbalta (duloxetine) for Chronic Pain: "I started taking 30mg of Cymbalta about a month ago. I was diagnosed with Fibromyalgia and was prescribed Cymbalta mainly for depression, but I must say that Cymbalta has significantly helped the chronic pain. I had side effects the first two weeks or so, but they mostly went away. As far as depression goes though, it hasn't really helped me."

   
8.0

Sutton12 (taken for 1 to 6 months) May 18, 2017

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Cymbalta (duloxetine) for Depression: "I've been having anxiety and depression issues recently and since I've had back surgery and residual pain, my doc put me on 40 mg of Cymbalta. About 3 hours after I took my first dose I had the worst migraine I've ever had in my life, coupled with nausea, finally vomiting, cold chills, auditory hallucinations (low rumbling sound, plus my tinnitus got worse,) sleeplessness, loss of appetite and everything tasted like aspirin. The next morning my wife and I attempted to have sex. While I did have an erection, after almost two hours of trying I never even got close to an orgasm. Now I'm in some discomfort. For a drug that's supposed to make me feel better, I'd never take it again."

joebloe256 (taken for less than 1 month) May 17, 2017

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Cymbalta (duloxetine) for Fibromyalgia: "Had been in a great deal of pain for over 3 years was diagnosed with fibromyalgia 2 months ago. My Doctor put me on Cymbalta 30mg once a day 2 weeks ago it took 5 days to kick in wow I am very pleased, I feel 90% pain free. I feel tired but I would rather be tired then in pain. It's nice to sleep pain free."

   
9.0

Chasewen May 17, 2017

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For Peripheral Neuropathy: "Duloxetine at 40mg did nothing for my neuropathic pain but on increasing the dose to 60mg I did get some relief. Unfortunately as one of the previous reviewers suggested I had problems urinating so yes it probably does help with incontinence."

   
7.0

Bobknob May 16, 2017

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Cymbalta (duloxetine) for Anxiety: "I feel like some of you people commenting on how inept the doctors are at prescribing medication for you fail to realize how medications affect people differently. You had a bad experience? That is in no way, shape or form the doctors fault. At all. Your body chemistry is just different than they expected. These psychiatric issues are not an exact science. Medicine is not an exact science. That aside, I've only been on Cymbalta for about a month but I have already noticed a vast improvement. I feel less anxious overall and haven't experienced a panic attack since I started on it. Again this isn't an exact science and sometimes it takes experimentation to get the right combination. Hopefully I've found a proper solution to my issues."

   
9.0

MomoRose May 15, 2017

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Cymbalta (duloxetine) for Major Depressive Disorder: "although OK when I first stated to take this 30mg caps, then increased to 60 mg daily...after some years , I am showing more signs of tiredness, confusion, anxiety, hot flushes, and forgetfulness and general mental decline, and still get depressed, among symptoms....am truly concerned about this, as is my Husband and children (as I am not yet 65 yrs old)...and have always been in good health. I do not smoke, do drugs, and very seldom drink alcohol...."

   
6.0

Anna - Rose S May 15, 2017

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For Peripheral Neuropathy: "Started Cymbalta, but also started gabapentin at the same time. Not sure which drug has caused some relief with the intense cold and pain feeling in my feet. It seems most folks are having problems with hot feelings along with pain in their feet. My feet are freezing. I'm 46 and my wife and I had a great sexual relationship. The Cymbalta has totally killed my libido and ability to get or maintain an erection. She's supportive, but I can't keep on with this diminished sex drive. I'm so tired of every med having such terrible side effects and it seems doc's just don't get it...."

   
3.0

side effects, side effects (taken for 1 to 2 years) May 15, 2017

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Cymbalta (duloxetine) for Depression: "Previous med Lexapro quit working after several years. Cymbalta seemed to work for the 1st week but I think it may have been placebo effect, after about a week my body started hurting and feeling hot from the inside especially my legs below my knees. After about 3 weeks stiff neck, hot flashes, restlessness, anxiety, headaches. 4 weeks all these plus talking in sleep, joint pain, body aches, stiff feeling, trouble focusing and I asked to be taken off it. I was only at 30mg."

   
1.0

Kypr May 11, 2017

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Cymbalta (duloxetine) for Chronic Pain: "It's not working for my functional abdominal pain"

   
1.0

Asidar (taken for less than 1 month) May 10, 2017

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Cymbalta (duloxetine) for Depression: "Horrible headache, drowsiness, feeling of paralysis, and diarrhea"

   
1.0

lonesomecharlie (taken for less than 1 month) May 9, 2017

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Cymbalta (duloxetine) for Fibromyalgia: "For almost 2 years I had felt like I was exhausted and in pain all of the time. Was told that it was osteoarthritis and because of my getting adult acquired flat feet. Finally went to an arthritis doctor who said it was fibromyalgia and started on Cymbalta two weeks ago. Within 5 days, I felt relief. It have given me hope to be able to do things without constant pain. I still get tired easily, but I can finally sleep at night and not nearly as stiff in the morning. I was scared to death when reading about the side effects. Other than a headache for a few days... that was all for me. Sooo glad it has changed my life."

   
9.0

PJN May 5, 2017

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "My thoughts on Cymbalta: Cymbalta has left me in a fog. I have no feelings- NONE. Driving is a chore as my eyes are excessively shifty. God forbid you ever forget to take your medication as you will be stricken with these obnoxious little shocks (which I've recently learned were called 'brain zaps'.) My heart beat is erratic. My brain is unable to form the right words when I talk which causes me to pause when I speak. I zone out regularly. I've been trying to taper off of this medication and am on day 9. The withdrawals are debilitating. I cannot focus. My chest and my jaw are tense. My fog has worsened significantly. Driving is dangerous as my vision is blurred. I am angry and easily agitated. I feel like crying but I can't. JUST SAY NO!!"

   
1.0

Anonymous (taken for 2 to 5 years) May 3, 2017

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Cymbalta (duloxetine) for Fibromyalgia: "I have fibromyalgia, and have had this condition for many years. I tried Cymbalta for about two weeks, and never felt like I was in my right mind at all during the time I took it. I would much rather deal with my pain, and feel somewhat alive and painful, rather than a zombie. I do not recommend this drug: it's hard on the liver, your urine will smell very bad, you're going to be extremely sleepy, and a feeling of being not quite right. If that's what it takes to take pain away, I'd much rather work on massage, de-stressing techniques, walks, and praying than to feel like half a human being. That's been my experience, I glad I had the experience, as it taught me there's no easy route to pain relief. My hope is the new sodium-blockers!"

   
1.0

EspírituSpirit May 3, 2017

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Cymbalta (duloxetine) for Depression: "I just started it , but felt it working already. Compare to Citalopram that I used before. I'm excited cause I have hope that Cymbalta will help with my depression and my back pain"

   
8.0

sylla April 27, 2017

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Cymbalta (duloxetine) for Depression: "First 24 hours my experience is as follows: I made up a joke about my experience since I had lots of time last night to think about it; I certainly wasn't sleeping. So I go to this really sleazy bar called 'The Cymbalta'. I order a shot of E Coli. I'm still standing so I tell the bartender to pour me some Dysentery. Then I try a frosty mug of Swine Flu. In other words, this stuff is like taking poison! My idea for Contraindications. 1) Not recommended for anyone who is actually alive. 2) Not recommended if you are more than 10 feet away from a toilet bowl. Yeah, I know all drugs have side effects, and this probably a transitory condition that will eventually go away. Maybe. I just don't think I can wait for the "feeling better" part to begin"

   
1.0

Californado (taken for less than 1 month) April 26, 2017

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Cymbalta (duloxetine) for Depression: "I feel very conflicted about this medication. For about 80% of the day it helps me to be more stable and less reactionary. But then every day or every other day I have a breakdown and start sobbing, get very moody and paranoid, accuse my partner of not loving/caring about me, want to self harm and die. It has helped my chronic pain and doesn't cause me to dissociate constantly like many antidepressants do. However, I'm not sure it's worth it because of the breakdowns, but I'm scared to go off of it because I heard withdrawal is awful. I am just about ready to give up on medication altogether at this point."

   
4.0

Yeti2 April 26, 2017

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Cymbalta (duloxetine) for Depression: "Cymbalta has been an incredible drug for me. Since taking Cymbalta, I have been able to enjoy life more, sleep less and feeling more refreshed, reduction in pain, and improved memory and concentration. Recently, I have been studying for an exam. This is a hard exam, that I previously had failed before, while not taking Cymbalta. I started taking Cymbalta, approximately in January. The months leading up to the exam, I was more focused, and able to concentrate better than I can last remember. I know that Cymbalta doesn't treat concentration or memory problems, but I think that sometimes if you are depressed, it can have a severe affect on concentration. Thank you Cymbalta for helping me in my life."

   
10

CymbaltaFan April 23, 2017

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Cymbalta (duloxetine) for Fibromyalgia: "I was diagnosed with fibromyalgia and the beginings of osteoarthritis. I'm a 24 year old mother of 3 children, and for me, Cymbalta has helped manage my pain. With 2 kiddos under the age of 3, and a special needs step-child, I don't have time to hurt, and I definitely can't lay around when I have a flare-up. Cymbalta has made the pain lessen from a screaming pain, to more of a whisper. Do I still have flares? Yes. But they are fewer and the pain is less, and I am able to control my flares better with the help of naproxen and a muscle relaxer. As far as side effects, I've noticed some loss of appetite and constipation. Every medication has some sort of negative effect, but you have to pick and choose what you are willing to live with."

   
8.0

Gracey Mae (taken for 1 to 6 months) April 21, 2017

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Cymbalta (duloxetine) for Anxiety: "Was put on this for anxiety/pain. Although it did help with anxiety, it made me very weak in the legs. So much so that I can't stand it. I am prescribed 60 mg, but I take 15 mg to keep the edge off. Im told weakness in muscles is not a side effect. Garbage ! I see in some comments that few others have it. Doctors act like we don't know our own bodies. ...So frustrating!"

   
1.0

nervousnelly9 (taken for 1 to 6 months) April 20, 2017

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Cymbalta (duloxetine) for Anxiety: "I have never in my life functioned properly until cymbalta, I have gone from panic attacks , to public speaking with no hesitation , I finally have a real life , I don't over stress , I no longer ruminate , no shakings , no lasting side effects , a bit hyper and loss of libido but sorted out in a few months, I never want to come of it , changed my life totally , been on 60 mgs for 20 months"

   
9.0

may78 (taken for 1 to 2 years) April 17, 2017

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Cymbalta (duloxetine) for Fibromyalgia: "Severe constipation, horrible horrible time it gave me,I don't care what anyone says,I was on it for 6 weeks and had to take laxatives every other night just to get relief before it finally hit me what was happening, I went off it right away, terrible drug,I'd rather live with any kind of pain then to ever go through that again!!!!"

   
3.0

Samby April 16, 2017

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "My new doctor recently switched me from klonopin to Cymbalta. I'd been taking Klonopin for two years at a low dose with NO issues, but this doctor can't help meddling. Anyway, this Cymbalta is a nightmare. I'm not depressed, just have anxiety, so why am I taking this? I've been so edgy and nauseous since starting it. I can't sleep, and sit in meetings at work spacing out. Never take this medication. I'm seeing my doc next week and am just going to flatly say I'm not taking this anymore. Luckily a different doc prescribes the Klonopin."

   
1.0

Jame F April 15, 2017

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Cymbalta (duloxetine) for Generalized Anxiety Disorder: "Within 2 hours of taking the medication, my brain lit up, it felt like I was high. I couldn't contain the energy, so I went for a run. By midway through the day I went to the park with my nephews, I took them on the swings. I thought I'd go on with them, so I started swinging and it felt like I was going to die. The most terrible feeling of fear I have ever experienced. It felt like I was free falling. I had a total panic attack. At the end of it I freaked out and just needed to get home. Could barely drive or focus. By day two I started feeling terrible raw feeling in my stomach, fought the feeling of vomiting most of the day, exhausted detached. My brain would fluctuate between euphoria and complete inability to calculate or communicate."

   
3.0

Dr stranglove April 14, 2017

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Cymbalta (duloxetine) for Major Depressive Disorder: "I started this drug back in the summer-ish of 2016. I was given 30 mg, which, let me say, was [at the time] The Holy Grail. I lost a bunch of weight, because it had helped me feel good enough to stop emotionally eating. Started on 60 mg, and it felt like a placebo. I accidentally stopped taking it for about 5 days and experienced physical withdrawals which I wasn't warned about until I googled. I'm currently weening myself off of it, because I refuse to be a slave to this or any other drug."

   
2.0

purple reign (taken for 6 months to 1 year) April 13, 2017

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