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Medications for Hot Flashes

About Hot Flashes

A hot flash is a brief feeling of intense warmth and sweating. Hot flashes commonly occur in women around the time of menopause.

Drugs used to treat Hot Flashes

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
venlafaxine Off-label 6.7 131 reviews
Rx C N X

Generic name: venlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

gabapentin Off-label 8.6 106 reviews
Rx C N X

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

paroxetine 7.2 94 reviews
Rx D N X

Generic name: paroxetine systemic

Brand name:  Brisdelle

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Brisdelle 6.5 35 reviews
Rx D N X

Generic name: paroxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

fluoxetine Off-label 7.6 38 reviews
Rx C N X

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

esterified estrogens / methyltestosterone 9.3 4 reviews
Rx X 3

Generic name: esterified estrogens / methyltestosterone systemic

Brand names:  Covaryx, Covaryx HS, EEMT, EEMT HS …show all

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

Duavee 7.6 14 reviews
Rx X N

Generic name: bazedoxifene / conjugated estrogens systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

citalopram Off-label 5.7 8 reviews
Rx C N X

Generic name: citalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

duloxetine Off-label 5.9 15 reviews
Rx C N X

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

megestrol 9.3 5 reviews
Rx X N

Generic name: megestrol systemic

Drug class: hormones/antineoplastics, progestins

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

mirtazapine Off-label 5.0 5 reviews
Rx C N X

Generic name: mirtazapine systemic

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

desvenlafaxine Off-label 9.5 2 reviews
Rx C N X

Generic name: desvenlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

bazedoxifene / conjugated estrogens 7.6 14 reviews
Rx X N

Generic name: bazedoxifene / conjugated estrogens systemic

Brand name:  Duavee

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Covaryx Rate Add review
Rx X 3

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Covaryx HS Rate Add review
Rx X 3

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

EEMT 9.0 1 review
Rx X 3

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

EEMT HS Rate Add review
Rx X 3

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

Alternative treatments for Hot Flashes

The following products are considered to be alternative treatments or natural remedies for Hot Flashes. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Hot Flashes.

  • Evening primrose

Learn more about Hot Flashes

Symptoms and treatments

Mayo Clinic Reference

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.