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Medications for Hot Flashes

What is Hot Flashes:  A hot flash is a brief feeling of intense warmth and sweating. Hot flashes commonly occur in women around the time of menopause.

Medications to treat Hot Flashes

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
venlafaxine Off Label C N X 70 reviews
7.0

Generic name: venlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Brisdelle D N X 31 reviews
6.0

Generic name: paroxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
gabapentin Off Label C N X 74 reviews
8.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
paroxetine D N X 77 reviews
7.0

Generic name: paroxetine systemic

Brand name:  Brisdelle

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Estratest X 3 1 review
10

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

 
fluoxetine Off Label C N X 18 reviews
7.0

Generic name: fluoxetine systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Duavee X N 5 reviews
9.0

Generic name: bazedoxifene / conjugated estrogens systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
esterified estrogens / methyltestosterone X 3 3 reviews
7.0

Generic name: esterified estrogens / methyltestosterone systemic

Brand names:  Estratest, Covaryx, Estratest H.S., Covaryx HS, EEMT, Menogen, EEMT DS, Essian, EEMT HS, Essian H.S.

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Megace Off Label X N 1 review
8.0

Generic name: megestrol systemic

Drug class: hormones/antineoplastics, progestins

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Covaryx X 3 Add review
4.0

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Estratest H.S. X 3 2 reviews
9.0

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

 
megestrol Off Label X N 3 reviews
8.0

Generic name: megestrol systemic

Brand names:  Megace, Megace ES

Drug class: hormones/antineoplastics, progestins

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
mirtazapine Off Label C N X 1 review
8.0

Generic name: mirtazapine systemic

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
citalopram Off Label C N X 6 reviews
4.0

Generic name: citalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
duloxetine Off Label C N X 9 reviews
6.0

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Covaryx HS X 3 Add review Rate

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

 
Megace ES Off Label X N Add review Rate

Generic name: megestrol systemic

Drug class: hormones/antineoplastics, progestins

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
bazedoxifene / conjugated estrogens X N 5 reviews
9.0

Generic name: bazedoxifene / conjugated estrogens systemic

Brand name:  Duavee

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
EEMT X 3 Add review Rate

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Menogen X 3 Add review Rate

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

 
desvenlafaxine Off Label C N X 1 review
10

Generic name: desvenlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
EEMT DS X 3 Add review Rate

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

 
Essian X 3 Add review Rate

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

 
EEMT HS X 3 Add review Rate

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

 
Essian H.S. X 3 Add review Rate

Generic name: esterified estrogens / methyltestosterone systemic

Drug class: sex hormone combinations

For consumers: dosage, interactions, side effects

 

Alternative treatments for Hot Flashes

The following products are considered to be alternative treatments or natural remedies for Hot Flashes. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Hot Flashes.

  • Evening primrose

Learn more about Hot Flashes

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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