Skip to main content


Generic name: estradiol and progesteroneES-tra-DYE-ol-and-pro-JES-ter-one ]
Drug class: Sex hormone combinations

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 4, 2024.

What is Bijuva?

Bijuva capsules contains a combination of estradiol (a form of estrogen) and progesterone. Both are female hormones.

Bijuva is used to reduce moderate to severe hot flashes caused by menopause.

Bijuva is for use only in a woman who has not had her uterus removed.


You should not use Bijuva if your uterus has been removed, or if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Call your doctor if you have any vaginal bleeding.

Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Bijuva should not be used to prevent heart disease, stroke, or dementia.

Before taking this medicine

You should not take Bijuva if your uterus has been removed, or if you have:

To make sure Bijuva is safe for you, tell your doctor if you have ever had:

Bijuva should not be used to prevent heart disease, stroke, or dementia. This medicine may actually increase your risk of developing these conditions.

Estrogens can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.

Estrogens may also increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.

Bijuva is not for use in a woman who is pregnant or breast-feeding.

How should I take Bijuva?

Take Bijuva exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Take Bijuva capsules with food.

If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Bijuva.

Call your doctor if you have any unusual vaginal bleeding.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis and have a mammogram every year while using Bijuva.

Store Bijuva capsules at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Postmenopausal Symptoms:

1 capsule (estradiol 1 mg/progesterone 100 mg) orally once a day in the evening with food

-Hormone replacement therapy should be limited to the shortest duration consistent with treatment goals and risks for the individual women.
-Reevaluate periodically to determine if treatment is still necessary.

Use: Treatment of moderate to severe vasomotor symptoms due to menopause.

What happens if I miss a dose?

Take the medicine (with food) as soon as you can, but skip the missed dose if your next dose is due in less than 2 hours. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using this medicine.

Grapefruit may interact with this medicine and lead to unwanted side effects. Avoid the use of grapefruit products.

Bijuva side effects

Get emergency medical help if you have signs of an allergic reaction to Bijuva: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Common Bijuva side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Bijuva?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with estradiol and progesterone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Bijuva only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.