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Osphena User Reviews & Ratings

Osphena has an average rating of 4.9 out of 10 from a total of 45 reviews on Drugs.com. 28% of reviewers reported a positive experience, while 44% reported a negative experience.

Reviews for Osphena

  • Marth...
  • Taken for 1 to 6 months
  • April 9, 2015

For Dyspareunia "This medication started working immediately. Within three days--more moisture. Within the next week, my interest in sex returned and I felt a major decrease in pain. I have been using this medication for 5 months now. Am I completely discomfort free? No. However, with use of a lubricant like coconut oil (best I've used) or olive oil (second best), both of which are the most like the body's natural moisture and some modifications in position or speed, this medicine has been a miracle for us. Unlike when we were young, it takes more preparation to be physically ready for intercourse, but we've adapted to those changes. I was/am frightened by the potential side effects. The only drawback for me at this point is an increase night sweats"

10 / 10
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98 Report
  • Jujuh...
  • March 5, 2016

For Dyspareunia "Sex had become so painful and no matter how much lubricant we used it just did not work. I dreaded sex and had no desire for it. I suffered for 3 years. One my yearly exam with Gynecologist she told me I was fire engine red down there so we discussed Osphena. After three days I noticed a difference. This is hard to share but I know feel like I am 30 down there LOL ( I am 50) . I have sexual urges again. I get lubrication just thinking about sex. My husband is thrilled and said its like before my menopause. I have nothing bad to say about this. It has given me back my sex life. I must admit I am worried about the side effects that can happen. So, I want to keep check ups regularly. I have heard some gain weight on this. I have not."

10 / 10
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70 Report
  • Trave...
  • Taken for 1 to 6 months
  • July 21, 2016

For Dyspareunia "I am a 58 year old woman who entered menopause at 40. I have dealt with severe dispariunia, vaginal atrophy and dryness for years now. I have tried everything on the market. My doctor has given me prescriptions for creams, HRT, suppositories, none of which gave me anything but temporary relief. Intercourse has been extremely painful and difficult. After talking to my doctor at length, I decided to try it. I noticed a significant difference within 5 days. I was nearly pain free during intercourse! Then the headaches began. A dull, consistent ache in the right side of my head. There was also intermittent nausea. This medication is a God send IF you don't suffer any side effects. Unfortunately, I can no longer take Osphena."

7 / 10
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57 Report

Frequently asked questions

  • Sweaty...
  • Taken for 1 to 6 months
  • April 8, 2019

For Vaginal Dryness "I started this medication about 3 months ago and it had taken that long for it to work on me. Then I realized I’ve gained 10 pounds in that three months and the hot flashes are extreme with lots of sweating. Yes it did what it was supposed to do, but I feel bloated, fat, sweaty and have experienced leg cramps. Bottom line, not for me."

3 / 10
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38 Report
  • Anonymous
  • Taken for 1 to 6 months
  • June 4, 2019

For Dyspareunia "This drug has renewed my sex life! My husband is thrilled and I’m pretty darn happy, too! I was getting depressed about how painful sex was and how little of it we were having. Now, it’s like I was 20 years ago!"

8 / 10
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37 Report

Are you taking this medicine?

  • gerte...
  • June 7, 2017

For Dyspareunia "I have always had an active sex life; at about age 59, sex became very painful. Put up with it for several years until I discovered Osphena. It has made life so much better. There is still some discomfort, but that is a minimal price to pay to be intimate with my husband of 45 years. I would highly recommend this drug. :)"

10 / 10
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43 Report
  • Happy...
  • Taken for 2 to 5 years
  • October 27, 2017

For Dyspareunia "I am 65, have taken Osphena for about 2 1/2 years now, no side effects ever noted. How quickly I had positive results after starting this med, I do not remember. I do know that my sexual desire increased, and my poor once-dry vagina now lubricates with even the thought of having intercourse. I make sure I do everything I can to stay healthy, so I can continue this medication and stay sexually active for a long time. My husband is thrilled, too!"

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39 Report
  • willow
  • November 10, 2015

For Dyspareunia "Made a significant positive difference in post-menopause symptoms. However, substantial side effects, worst off which is facial edema with distortion to facial features. Tested this by stopping the med several times to clear it from system and when did this, edema disappeared but reappeared once resume the drug. Also, strong hot flashes and sweating. No weight gain."

8 / 10
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47 Report
  • Toni
  • September 23, 2018

For Dyspareunia "For years after having a complete hysterectomy at age 45, intercourse was very painful, I have been taking Osphena for three years without any side effects. To me it is a miracle drug, I had given up on sex, and now I enjoy sex with my husband on a regular basis without worrying about possible side effects , I would rather live a full life with my husband than not having a life at all. Thank you Osphena"

10 / 10
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34 Report
  • Janed
  • Taken for 1 to 6 months
  • July 31, 2019

For Dyspareunia "At first it was definitely helping with dryness. Then I was wetting my pants all the time and I got a horrific yeast infection -- took three rounds of medication to fix it. I also felt stressed -- lack of energy and weakness. I didn't realize how bad that had gotten until I went off it. The yeast infection was the final straw. Then, after being off it for a week ovarian pain began and I now will need to get this checked off. I went through early menopause (46). I think I have exhausted all options for the pain at this point."

1 / 10
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30 Report
  • Wwotw
  • Taken for 1 to 2 years
  • July 24, 2019

For Vaginal Dryness "I have taken this for over a year. Initially, other than being a little more tired than usual, I was pleased with the results. The last six months I have had severe night sweats, and still feel overall tiredness. I am physically more fit than many women my age. (66). I decided to quit this and try non hormone alternative treatments. After three days I did not have the night sweats. Will see if my energy returns!"

5 / 10
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30 Report
  • slmar...
  • July 5, 2015

For Dyspareunia "Just started taking Osphena after fighting with insurance for almost 3 years to allow it to be covered. (cash price $204 .00) After 3 days use I have noticed an increase of natural vaginal lubricant. I can't wait to start having a sex life again with my husband! Looking forward to the promises and not to worried about the side effects. Thank You Osphena for bringing us back to life!"

10 / 10
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45 Report
  • Molly
  • Taken for 6 months to 1 year
  • September 12, 2019

For Vaginal Dryness "I have been on Osphena for 6 months due painful sex and it unfortunately is not helping ! I have also always been a person of a nsc Wright of 120, even 9 months pregnant didn’t weigh what I do now, I am at 149lbs and realized all the weight increases have occurred while on this med! Nothing else has changed so with still painful sex and lack of interest along with the major weigh gain I am stopping usage! Going back on my old low dose estrogen med!"

6 / 10
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27 Report
  • kitkat
  • February 11, 2019

For Postmenopausal Symptoms "This did not work for me. Since I started taking this drug, I have had increased vaginal pain, increased urination, and weight gain to the fact that I have gone up 2 pants sizes. I see my doctor this week and am getting off of this drug. I doubt if there is an alternative at this point, they don't make many options for women."

2 / 10
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28 Report
  • SheXy
  • Taken for less than 1 month
  • November 23, 2016

For Dyspareunia "Everyone is obviously so different. My experience wasn't even close to as positive as some of the others have mentioned. Thankfully I received a physicians sample, and did not purchase it. I took about 6 days worth, and noticed increased discharge. After taking it for another 7 days, I woke up with the worst headache. Headaches are very rare for me. Then I noticed some spotting on my underware. By the evening I was sweating heavily, and just felt horrible. It was then that I decided to look up side effects. I have discontinued taking this medication. It's just not worth the side effects for me. Your mileage will certainly vary."

1 / 10
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36 Report
  • Letfr...
  • Taken for 1 to 6 months
  • January 1, 2019

For Dyspareunia "I've been taking Osphena for about 2 months. I've had no side effects up until now, and the pain I was experiencing during sex has subsided a lot. Its not perfect yet, but better then it was. However, suddenly I've developed a yeast infection. I've never had yeast infections -only ones out of the blue, only after finishing a course of antibiotics. I read that yeast infections can occur when there is an increase in estrogen. So now I am wondering if I need to stop taking osphena and if its the reason I have a yeast infection."

6 / 10
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27 Report
  • myy
  • July 5, 2018

For Dyspareunia "I've been taking osphena for 8 months now and it helped my vaginal dryness..but side effects are hot flashes, slight headache and gaining weight! To date is my heaviest weight in my entire life...anyhow, before I had to pay $0 with my old insurance but now I have a new insurance and its not covering the osphena. It's so expensive to pay $243 every time I refill. I can't afford it anymore. My obgyn said there's no generic for osphena and she didn't give me any alternative. :("

8 / 10
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27 Report
  • Dancing...
  • Taken for 1 to 6 months
  • September 15, 2016

For Dyspareunia "I noticed some improvement after a few weeks, but still had some mild discomfort and spotting after intercourse. I have gained weight (about 5 pounds in a 6-week period), I have headaches, I have hot flashes and some severe leg cramping (not a normal problem even with my line dancing). I am going to discontinue this drug."

7 / 10
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30 Report
  • Cat...
  • Taken for 1 to 6 months
  • December 18, 2019

For Vaginal Dryness "I am having horrible headaches, leg cramps, drenched in sweat to the point where I am waking up in the middle of the night dehydrated, fatigue, and had none of that before taking. It started about a week into taking the pills. Am going to stop immediately and search for an alternative."

3 / 10
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19 Report
  • Nora
  • Taken for 2 to 5 years
  • December 10, 2020

For Dyspareunia "I've been using Osphena for several years and it changed my life. I could not have sex after menopause due to severe pain-like broken glass. I've had no side effects, no weight gain or bloating. Some leg cramps are easily handled with Ca/ Mg Supplement. BUT in addition my gyno has me using melted cocoanut oil on penetration. She said do not use OTC lubricants as they have ingredients that are drying. I also used a vagdilator for awhile as my muscles were so tight from pain avoidance."

10 / 10
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15 Report
  • Micky
  • Taken for 6 months to 1 year
  • December 23, 2019

For Atrophic Vaginitis "For us, this drug Osphena saved our sex life. I’ve been on it for a year with no side effects. I was embarrassed to go to the doctor and talk about it and once I got on this medication I wished I had done it sooner."

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18 Report
  • hot...
  • Taken for 1 to 2 years
  • September 30, 2017

For Dyspareunia "Osphenia came into my life via a rep to the office. I'm a Female GP who sees vag complaints daily. I personally had gotten through the big pump bottle of lube every few months. Osphenia makes me as wet and tight as I was before we married 28 yrs ago according to my husband. Much better sex for both of us and no lube needed .Chronic headaches lifelong, no worse."

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24 Report
  • Ann
  • Taken for 1 to 6 months
  • November 7, 2019

For Atrophic Vaginitis "When I started the Osphena I felt better, the hot flashes were horrible. Didn't notice any difference in sex, still hurt. By 3rd month slight headache constantly and leg cramps were bad. Called doctor and stopped taking."

4 / 10
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17 Report
  • Eiano
  • Taken for 1 to 6 months
  • March 27, 2018

For Dyspareunia "I've been taking Osphena for two months. It has definitely helped with dryness. However I have constant discharge and have gained 6 lbs. I am not eating more and was the same weight for years. It is crazy. I thought that I would stop gaining and my body would go back to normal but it hasn't. I'm going off the medicine and trying the Femilift."

5 / 10
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21 Report
  • KJano
  • Taken for 6 months to 1 year
  • September 23, 2019

For Atrophic Vaginitis "This medicine did help with dryness, BUT after 6 months of night sweats and hot flashes (worse than I ever experienced during menopause) it just wasn’t worth it. Then came a horrible case of BV, which was the final straw."

4 / 10
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16 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.