Osphena and Weight Gain: What Users Say

• Juj...
• March 5, 2016

For Dyspareunia "Sex had become so painful and no matter how much lubricant we used, it just did not work. I dreaded sex and had no desire for it. I suffered for 3 years. On my yearly exam with my gynecologist, she told me I was fire engine red down there, so we discussed Osphena. After three days, I noticed a difference. This is hard to share, but I now feel like I am 30 down there (I am 50). I have sexual urges again. I get lubrication just thinking about sex. My husband is thrilled and said it's like before my menopause. I have nothing bad to say about this. It has given me back my sex life. I must admit I am worried about the side effects that can happen, so I want to keep check-ups regularly. I have heard some gain weight on this. I have not."

• Swe...
• Taken for 1 to 6 months
• April 8, 2019

For Vaginal Dryness "I started this medication about 3 months ago, and it had taken that long for it to work on me. Then I realized I’ve gained 10 pounds in those three months, and the hot flashes are extreme, with lots of sweating. Yes, it did what it was supposed to do, but I feel bloated, fat, sweaty, and have experienced leg cramps. Bottom line, not for me."

• kit...
• February 11, 2019

For Postmenopausal Symptoms "This did not work for me. Since I started taking this drug, I have had increased vaginal pain, increased urination, and weight gain to the fact that I have gone up 2 pant sizes. I see my doctor this week and am getting off of this drug. I doubt if there is an alternative at this point, they don't make many options for women."

• Mol...
• Taken for 6 months to 1 year
• September 12, 2019

For Vaginal Dryness "I have been on Osphena for 6 months due to painful sex, and it unfortunately is not helping! I have also always been a person of a nice weight of 120, even 9 months pregnant didn’t weigh what I do now. I am at 149 lbs and realized all the weight increases have occurred while on this med! Nothing else has changed, so with still painful sex and lack of interest along with the major weight gain, I am stopping usage! Going back on my old low-dose estrogen med!"

• myy...
• July 5, 2018

For Dyspareunia "I've been taking Osphena for 8 months now, and it helped my vaginal dryness, but side effects are hot flashes, slight headache, and gaining weight! To date is my heaviest weight in my entire life. Anyhow, before, I had to pay $0 with my old insurance, but now I have a new insurance, and it's not covering the Osphena. It's so expensive to pay $243 every time I refill. I can't afford it anymore. My ob-gyn said there's no generic for Osphena, and she didn't give me any alternative. :("

• Dan...
• Taken for 1 to 6 months
• September 15, 2016

For Dyspareunia "I noticed some improvement after a few weeks, but still had some mild discomfort and spotting after intercourse. I have gained weight (about 5 pounds in a 6-week period), I have headaches, I have hot flashes, and some severe leg cramping (not a normal problem even with my line dancing). I am going to discontinue this drug."

• Eia...
• Taken for 1 to 6 months
• March 27, 2018

For Dyspareunia "I've been taking Osphena for two months. It has definitely helped with dryness. However, I have constant discharge and have gained 6 lbs. I am not eating more and was the same weight for years. It is crazy. I thought that I would stop gaining and my body would go back to normal, but it hasn't. I'm going off the medicine and trying the Femilift."

• Sun...
• Taken for 1 to 6 months
• September 13, 2020

For Vaginal Dryness "I’ve been taking Osphena for 1 month now. The first week started the hot flashes and night sweats during the night that wake me. Muscle spasms in my legs. Weight gain and feeling bloated. My Dr advised to continue for at least 12 weeks, not sure if I can manage 2 more months of side effects."

• GaN...
• Taken for 1 to 6 months
• April 6, 2020

For Dyspareunia "I've been taking Osphena for 3 months for painful intercourse. My doctor said to give it 3 months, and I did, but sex still hurts, and the side effects are pretty bothersome. Hot flashes, weight gain, bloating, and the worst is the bitchiness. My husband said he'd rather have his sweet wife back. I'm calling the doctor today, but leaning toward stopping it."

• Anonymous
• June 14, 2020

For Postmenopausal Symptoms "I took this medication for 3 months. The side effects are just not worth it. I experienced horrible hot flashes and sweating profusely. You will also gain weight on this medication. My doctor assured me that neither were a side effect... not true. Just read these reviews."

• Mew...
• Taken for less than 1 month
• August 25, 2020

For Vaginal Dryness "Ok, so I started over a week ago on Osphena, and every day I have horrible migraine. I'm tired and am starting to feel the weight gain and bloating also. No night sweats or leg cramps. But I am not going to continue. I read the side effects, and it's not worth it to me."

• Cal...
• Taken for 2 to 5 years
• January 20, 2023

For Vaginal Dryness "I have been taking this for 3+ years, hoping to experience less painful intercourse. I cannot detect any benefits of taking Osphena, and after reading reviews, I am wondering if my severe hot flashes, night sweats, leg cramps, fatigue, and weight gain are related. I'm stopping this drug today. It may not be causing all of the above symptoms, but it certainly isn't providing any detectable benefits. I'm done."

• Nan...
• Taken for 1 to 6 months
• January 2, 2020

For Vaginal Dryness "Really helped with vaginal dryness and improved my sex life immensely. The only side effect is weight gain of about 7 pounds."