What is the difference between Intrarosa and Osphena?
Intrarosa (prasterone) and Osphena (Ospemifene) are both treatments for moderate to severe dyspareunia - the medical term for difficult or painful sexual intercourse - a symptom of vulvar and vaginal atrophy, caused by menopause. Falling estrogen levels play a key role in the development of menopausal symptoms.
There are a number of differences between Intrarosa and Osphena, including how they are administered, what they contain and how they work. See the table below for more details.
|First approved in the US||2016||2013|
|Type of drug||Steroid||Selective estrogen-receptor modulator (SERM)|
|How it works||Intrarosa is broken down in the body into active sex hormones (androgens and estrogens). Increasing estrogen levels helps to alleviate the symptoms of menopause||Osphena binds to estrogen receptors in the body. In some parts of the body this activates estrogenic pathways and in others it blocks them. Osphena is not a hormone, but it does mimic the effects of estrogen|
|Formulation||Vaginal insert||Oral tablet|
|How it's used||Inserted into the vagina using an applicator. Used once daily at bedtime||Swallowed once daily, with food|
|Adverse reactions||The most common adverse reactions (≥2%) are vaginal discharge and abnormal Pap smear||
The most common adverse reactions (≥1%) are:
- Food and Drug Administration (FDA). Intrarosa. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208470s001lbl.pdf. [Accessed March 2, 2021].
- Food and Drug Administration (FDA). Osphena. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/203505s015lbl.pdf. [Accessed March 2, 2021].
- Osphena website. Available from: https://www.osphena.com/. [Accessed March 2, 2021].
- Intrarosa website. Available from: https://us.intrarosa.com/. [Accessed March 2, 2021].