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What is the difference between Intrarosa and Osphena?

Medically reviewed by Last updated on Oct 7, 2019.

Official Answer


While both Intrarosa (prasterone) and Osphena (ospemifene) are used to help relieve pain during sexual intercourse in menopausal women, the way they work is different.

Intrarosa is a once-daily vaginal insert that provides replacement for the local deficiency in sex steroids with no significant increase in circulating estrogens or androgens.

Osphena is an oral tablet taken daily and in a class of drugs known as selective estrogen receptor modulators (SERMs). It works similar to the way an estrogen works, but without using hormones.

Painful sex (dyspareunia) may occur due to thinner and drier vaginal tissues due to reduced levels of estrogen that occur during menopause.

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