What is the difference between Intrarosa and Osphena?
Medically reviewed by N. France, BPharm. Last updated on March 2, 2021.
Intrarosa (prasterone) and Osphena (Ospemifene) are both treatments for moderate to severe dyspareunia - the medical term for difficult or painful sexual intercourse - a symptom of vulvar and vaginal atrophy, caused by menopause. Falling estrogen levels play a key role in the development of menopausal symptoms.
There are a number of differences between Intrarosa and Osphena, including how they are administered, what they contain and how they work. See the table below for more details.
|First approved in the US||2016||2013|
|Type of drug||Steroid||Selective estrogen-receptor modulator (SERM)|
|How it works||Intrarosa is broken down in the body into active sex hormones (androgens and estrogens). Increasing estrogen levels helps to alleviate the symptoms of menopause||Osphena binds to estrogen receptors in the body. In some parts of the body this activates estrogenic pathways and in others it blocks them. Osphena is not a hormone, but it does mimic the effects of estrogen|
|Formulation||Vaginal insert||Oral tablet|
|How it's used||Inserted into the vagina using an applicator. Used once daily at bedtime||Swallowed once daily, with food|
|Adverse reactions||The most common adverse reactions (≥2%) are vaginal discharge and abnormal Pap smear||
The most common adverse reactions (≥1%) are:
- Food and Drug Administration (FDA). Intrarosa. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208470s001lbl.pdf. [Accessed March 2, 2021].
- Food and Drug Administration (FDA). Osphena. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/203505s015lbl.pdf. [Accessed March 2, 2021].
- Osphena website. Available from: https://www.osphena.com/. [Accessed March 2, 2021].
- Intrarosa website. Available from: https://us.intrarosa.com/. [Accessed March 2, 2021].
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