Osphena and Headaches: What Users Say

• Tra...
• Taken for 1 to 6 months
• July 21, 2016

For Dyspareunia "I am a 58-year-old woman who entered menopause at 40. I have dealt with severe dyspareunia, vaginal atrophy, and dryness for years now. I have tried everything on the market. My doctor has given me prescriptions for creams, HRT, and suppositories, none of which gave me anything but temporary relief. Intercourse has been extremely painful and difficult. After talking to my doctor at length, I decided to try it. I noticed a significant difference within 5 days. I was nearly pain-free during intercourse! Then the headaches began. A dull, consistent ache in the right side of my head. There was also intermittent nausea. This medication is a Godsend IF you don't suffer any side effects. Unfortunately, I can no longer take Osphena."

• She...
• Taken for less than 1 month
• November 23, 2016

For Dyspareunia "Everyone is obviously so different. My experience wasn't even close to as positive as some of the others have mentioned. Thankfully, I received a physician's sample and did not purchase it. I took about 6 days' worth and noticed increased discharge. After taking it for another 7 days, I woke up with the worst headache. Headaches are very rare for me. Then I noticed some spotting on my underwear. By the evening, I was sweating heavily and just felt horrible. It was then that I decided to look up side effects. I have discontinued taking this medication. It's just not worth the side effects for me. Your mileage will certainly vary."

• myy...
• July 5, 2018

For Dyspareunia "I've been taking Osphena for 8 months now, and it helped my vaginal dryness, but side effects are hot flashes, slight headache, and gaining weight! To date is my heaviest weight in my entire life. Anyhow, before, I had to pay $0 with my old insurance, but now I have a new insurance, and it's not covering the Osphena. It's so expensive to pay $243 every time I refill. I can't afford it anymore. My ob-gyn said there's no generic for Osphena, and she didn't give me any alternative. :("

• Dan...
• Taken for 1 to 6 months
• September 15, 2016

For Dyspareunia "I noticed some improvement after a few weeks, but still had some mild discomfort and spotting after intercourse. I have gained weight (about 5 pounds in a 6-week period), I have headaches, I have hot flashes, and some severe leg cramping (not a normal problem even with my line dancing). I am going to discontinue this drug."

• hot...
• Taken for 1 to 2 years
• September 30, 2017

For Dyspareunia "Osphena came into my life via a rep to the office. I'm a female GP who sees vag complaints daily. I personally had gone through the big pump bottle of lube every few months. Osphena makes me as wet and tight as I was before we married 28 years ago, according to my husband. Much better sex for both of us and no lube needed. Chronic headaches lifelong, no worse."

• Cat...
• Taken for 1 to 6 months
• December 18, 2019

For Vaginal Dryness "I am having horrible headaches, leg cramps, drenched in sweat to the point where I am waking up in the middle of the night dehydrated, fatigue, and had none of that before taking. It started about a week into taking the pills. I am going to stop immediately and search for an alternative."

• Ann...
• Taken for 1 to 6 months
• November 7, 2019

For Atrophic Vaginitis "When I started the Osphena, I felt better, the hot flashes were horrible. Didn't notice any difference in sex, still hurt. By the 3rd month, a slight headache constantly and leg cramps were bad. Called the doctor and stopped taking."

• Ann...
• Taken for 1 to 6 months
• November 6, 2019

For Atrophic Vaginitis "When I started the Osphena, I felt better, the hot flashes were horrible. Didn't notice any difference in sex, still hurt. By the 3rd month, slight headache constantly and leg cramps were bad. Called the doctor and stopped taking."