Osphena and Hot Flashes: What Users Say

• Swe...
• Taken for 1 to 6 months
• April 8, 2019

For Vaginal Dryness "I started this medication about 3 months ago, and it had taken that long for it to work on me. Then I realized I’ve gained 10 pounds in those three months, and the hot flashes are extreme, with lots of sweating. Yes, it did what it was supposed to do, but I feel bloated, fat, sweaty, and have experienced leg cramps. Bottom line, not for me."

• wil...
• November 10, 2015

For Dyspareunia "Made a significant positive difference in post-menopause symptoms. However, substantial side effects, worst of which is facial edema with distortion to facial features. Tested this by stopping the med several times to clear it from the system, and when I did this, edema disappeared but reappeared once I resumed the drug. Also, strong hot flashes and sweating. No weight gain."

• myy...
• July 5, 2018

For Dyspareunia "I've been taking Osphena for 8 months now, and it helped my vaginal dryness, but side effects are hot flashes, slight headache, and gaining weight! To date is my heaviest weight in my entire life. Anyhow, before, I had to pay $0 with my old insurance, but now I have a new insurance, and it's not covering the Osphena. It's so expensive to pay $243 every time I refill. I can't afford it anymore. My ob-gyn said there's no generic for Osphena, and she didn't give me any alternative. :("

• Dan...
• Taken for 1 to 6 months
• September 15, 2016

For Dyspareunia "I noticed some improvement after a few weeks, but still had some mild discomfort and spotting after intercourse. I have gained weight (about 5 pounds in a 6-week period), I have headaches, I have hot flashes, and some severe leg cramping (not a normal problem even with my line dancing). I am going to discontinue this drug."

• Ann...
• Taken for 1 to 6 months
• November 7, 2019

For Atrophic Vaginitis "When I started the Osphena, I felt better, the hot flashes were horrible. Didn't notice any difference in sex, still hurt. By the 3rd month, a slight headache constantly and leg cramps were bad. Called the doctor and stopped taking."

• KJa...
• Taken for 6 months to 1 year
• September 23, 2019

For Atrophic Vaginitis "This medicine did help with dryness, but after 6 months of night sweats and hot flashes (worse than I ever experienced during menopause), it just wasn’t worth it. Then came a horrible case of BV, which was the final straw."

• GaN...
• Taken for 1 to 6 months
• April 6, 2020

For Dyspareunia "I've been taking Osphena for 3 months for painful intercourse. My doctor said to give it 3 months, and I did, but sex still hurts, and the side effects are pretty bothersome. Hot flashes, weight gain, bloating, and the worst is the bitchiness. My husband said he'd rather have his sweet wife back. I'm calling the doctor today, but leaning toward stopping it."

• Sun...
• Taken for 1 to 6 months
• September 13, 2020

For Vaginal Dryness "I’ve been taking Osphena for 1 month now. The first week started the hot flashes and night sweats during the night that wake me. Muscle spasms in my legs. Weight gain and feeling bloated. My Dr advised to continue for at least 12 weeks, not sure if I can manage 2 more months of side effects."

• Anonymous
• June 14, 2020

For Postmenopausal Symptoms "I took this medication for 3 months. The side effects are just not worth it. I experienced horrible hot flashes and sweating profusely. You will also gain weight on this medication. My doctor assured me that neither were a side effect... not true. Just read these reviews."

• Lab...
• May 2, 2019

For Perimenopausal Symptoms "I started Osphena to maybe help with worsening prolapse... along with pelvic PT. Then, 1.5 years later, I have had a hysterectomy due to endometrial cancer, also, I have had night sweats and hot flashes."

• Ann...
• Taken for 1 to 6 months
• November 6, 2019

For Atrophic Vaginitis "When I started the Osphena, I felt better, the hot flashes were horrible. Didn't notice any difference in sex, still hurt. By the 3rd month, slight headache constantly and leg cramps were bad. Called the doctor and stopped taking."

• Cal...
• Taken for 2 to 5 years
• January 20, 2023

For Vaginal Dryness "I have been taking this for 3+ years, hoping to experience less painful intercourse. I cannot detect any benefits of taking Osphena, and after reading reviews, I am wondering if my severe hot flashes, night sweats, leg cramps, fatigue, and weight gain are related. I'm stopping this drug today. It may not be causing all of the above symptoms, but it certainly isn't providing any detectable benefits. I'm done."

• Dol...
• Taken for less than 1 month
• September 5, 2016

For Dyspareunia "Horrible hot flashes and depression."

• Anonymous
• Taken for 1 to 6 months
• October 3, 2021

For Atrophic Vaginitis "Making hot flashes unbearable, coming too often and stronger. Is helping with dryness and painful intercourse."