Bijuva Side Effects
Generic Name: estradiol / progesterone
Note: This document contains side effect information about estradiol / progesterone. Some of the dosage forms listed on this page may not apply to the brand name Bijuva.
For the Consumer
Applies to estradiol/progesterone: oral capsule
Oral route (Capsule)
Estrogen Plus Progestin TherapyEstrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia.The Women's Health Initiative (WHI) estrogen plus progestin substudy reported increased risks of stroke, DVT, PE, and myocardial infarction.The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer.The WHI Memory Study (WHIMS) estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age of older.Estrogen-Alone TherapyThere is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens.Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia.The WHI estrogen-alone substudy reported increased risks of stroke and DVT.The WHIMS estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age or older.
Side effects requiring immediate medical attention
Along with its needed effects, estradiol / progesterone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking estradiol / progesterone:
- Breast tenderness
- non-menstrual vaginal bleeding
- pain in the pelvis
- white or brownish vaginal discharge
Incidence not known
- Blurred vision
- chest pain
- lightheadedness, dizziness, or fainting
- fast or irregular heartbeat
- sudden fainting
- unusual tiredness or weakness
For Healthcare Professionals
Applies to estradiol / progesterone: oral capsule
Common (1% to 10%): Vaginal bleeding, vaginal discharge, pelvic pain, disordered proliferative endometrium
During clinical trials, an endometrial biopsy revealed 1 case of endometrial hyperplasia (n=281). There were no cases in the placebo group (n=92). Four cases of disordered proliferative endometrium were reported in women receiving this drug.[Ref]
Very common (10% or more): Breast tenderness (10.4%)[Ref]
Common (1% to 10%): Headache[Ref]
1. "Product Information. Bijuva (estradiol-progesterone)." TherapeuticsMD, Boca Raton, FL.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
More about Bijuva (estradiol / progesterone)
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 2 Reviews
- Drug class: sex hormone combinations
- FDA Approval History