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Estradiol and progesterone

Generic name: estradiol and progesterone [ ES-tra-DYE-ol-and-proe-JES-ter-one ]
Brand name: Bijuva
Dosage form: oral capsule (0.5 mg-100 mg; 1 mg-100 mg)
Drug class: Sex hormone combinations

Medically reviewed by Drugs.com on Jul 23, 2024. Written by Cerner Multum.

What is estradiol and progesterone?

Estradiol and progesterone is used in menopausal adult women to reduce symptoms of moderate to severe "hot flashes".

Estradiol and progesterone may also be used for purposes not listed in this medication guide.

Estradiol and progesterone side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Estradiol and progesterone can increase your risk of blood clots, stroke, or heart attack. Get emergency medical help if you have: chest pain, pain, swelling or warmth in your leg, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath or trouble breathing.

Estradiol and progesterone may cause serious side effects. Call your doctor at once if you have:

Common side effects of estradiol and progesterone may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not take estradiol and progesterone if your uterus has been removed or if you have or have ever had: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, a heart attack, a stroke, a blood clot, or cancer of the breast or uterus.

Estradiol and progesterone may increase your risk of developing uterine cancer. Tell your doctor about any unusual vaginal bleeding right away.

Using this medicine can also increase your risk of blood clots, dementia, stroke, heart attack, or breast cancer. Estradiol and progesterone should not be used to prevent heart disease, stroke, or dementia.

Before taking this medicine

You should not take estradiol and progesterone if you are allergic to it, or if you have or have ever had:

This medicine is for use only in a woman who has not had her uterus removed (hysterectomy).

Estradiol and progesterone should not be used to prevent heart disease, stroke, or dementia. Using this medicine may increase your risk of blood clots, dementia, stroke, or heart attack, especially if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.

Tell your doctor if you have or have ever had:

Long-term use of estradiol and progesterone may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.

Do not use estradiol and progesterone if you are pregnant. Tell your doctor right away if you become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I take estradiol and progesterone?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take with food every evening.

If you need surgery, or will be on bed rest, tell your healthcare provider ahead of time that you are using estradiol and progesterone. You may need to stop using the medicine for a short time.

You will need frequent medical tests, and your next dose may change based on your response to treatment.

Your doctor will need to check your progress on a regular basis to determine how long you should use estradiol and progesterone. Self-examine your breasts for lumps on a monthly basis, and have pelvic exams and a mammogram every year while using estradiol and progesterone.

You should not stop taking estradiol and progesterone suddenly. Ask your doctor before stopping the medicine.

estradiol and progesterone can affect the results of certain medical tests. Tell any doctor who treats you that you are using estradiol and progesterone.

Store at room temperature away from moisture and heat.

Estradiol and progesterone dosing information

Usual Adult Dose for Postmenopausal Symptoms:

1 capsule (estradiol 1 mg/progesterone 100 mg) orally once a day in the evening with food

Comments:
-Hormone replacement therapy should be limited to the shortest duration consistent with treatment goals and risks for the individual women.
-Reevaluate periodically to determine if treatment is still necessary.

Use: Treatment of moderate to severe vasomotor symptoms due to menopause.

What happens if I miss a dose?

Take the medicine (with food) as soon as you can, but skip the missed dose if your next dose is due in less than 2 hours. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking estradiol and progesterone?

Avoid smoking. It can greatly increase your risk of blood clots, dementia, stroke, or heart attack while using estradiol and progesterone.

Grapefruit may interact with estradiol and progesterone and cause side effects. Avoid consuming grapefruit products.

What other drugs will affect estradiol and progesterone?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medicines less effective.

Many drugs can affect estradiol and progesterone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.

paroxetine, estradiol, Premarin, progesterone, megestrol, Estrace, Veozah, Prometrium, conjugated estrogens, fezolinetant

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.