Estradiol / progesterone Alternatives Compared
| Estradiol / progesterone | Progesterone | Clonidine |
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| Estradiol / progesterone | Progesterone | Clonidine |
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Prescription only
Prescribed for Perimenopausal Symptoms, Postmenopausal Symptoms, Menopausal Disorders, Hot Flashes. Estradiol / progesterone may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Progesterone is a hormone that is used to treat conditions associated with ovulation, fertility, menstruation, menopause, or abnormal uterine bleeding. It may be used in gender-affirming therapy to... View more |
Prescription only
Clonidine can be used to lower blood pressure and extended-release forms are used to treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects... View more |
Related suggestions Perimenopausal Symptoms
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| More about Estradiol / progesterone | More about Progesterone | More about Clonidine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Estradiol / progesterone has an average rating of 6.0 out of 10 from a total of 49 ratings on Drugs.com. 39% of reviewers reported a positive effect, while 27% reported a negative effect. |
Progesterone has an average rating of 6.5 out of 10 from a total of 78 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 21% reported a negative effect. |
Clonidine has an average rating of 7.1 out of 10 from a total of 778 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
View all Progesterone side effects |
View all Clonidine side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Progesterone prices |
View all Clonidine prices |
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| Dosage Forms | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
| Bijuva | Crinone, Cyclogest, Endometrin, First Progesterone MC10, First Progesterone MC5, Gestone, Milprosa, Prometrium | Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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26.47 hours |
1 hour |
15 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category B
No proven risk in humans
Oral Formulations
Category N
Not classified
Excluding Oral Formulations See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 416 drugs are known to interact with Estradiol / progesterone:
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A total of 221 drugs are known to interact with Progesterone:
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A total of 378 drugs are known to interact with Clonidine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||
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| First Approval Date | ||||||||||||||||||
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October 28, 2018 |
November 01, 1974 |
September 03, 1974 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient Resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.