Progestins are a group of naturally occurring or synthetic steroid hormones. The naturally occurring progestin is progesterone, which is secreted by the corpus luteum of the ovary, the placenta and also (in small amounts) by the adrenal cortex and testes. It prepares the inner lining of the uterus for pregnancy, and if pregnancy occurs it maintains the uterus through the pregnancy and prevents ovulation by the ovaries during pregnancy.
Mainly synthetic progestins are used in drug therapy. They are used to treat amenorrhea, premenstrual tension and abnormal uterine bleeding.
As they prevent ovulation, progestins are a major constituent of oral contraceptives and other forms of contraception.
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