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User Reviews for Megestrol

Also known as: Megace ES

Megestrol has an average rating of 7.4 out of 10 from a total of 122 ratings on Drugs.com. 65% of reviewers reported a positive experience, while 19% reported a negative experience.

Condition Avg. Rating Reviews Compare
Abnormal Uterine Bleeding  
7.0
51 reviews 100 medications
Weight Loss  Off-label
8.3
28 reviews 42 medications
Anorexia  
7.9
16 reviews 3 medications
Endometrial Hyperplasia  
5.3
13 reviews 1 medications
Endometrial Cancer  
7.3
8 reviews 7 medications
Hot Flashes  
9.3
5 reviews 17 medications
Cachexia  
9.0
1 reviews 1 medications
Summary of Megestrol reviews 7.4 122 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Megestrol

Ms D · Taken for less than 1 month · February 8, 2021

For Abnormal Uterine Bleeding: “I have experienced excessive uterine bleeding for about a year now! I am 56 years old and still peri menopausal. The bleeding and clotting became unbearable! I was told early on that it was normal and a part of transitioning to menopause. I finally sought help from a gyn because I refused to believe it was normal. I was prescribed megestrol acetate, 40 mg twice a day. It was like a miracle!! The bleeding decreased immediately, and now two weeks later, I have not seen any blood at all for two consecutive days!! Yes!! I feel liberated! Heavy bleeding controls your life and I haven't felt this way since before the issue started! So I'm thinking, after reading other's experiences, maybe the dosage was too low! Ask your doctor is it possible to increase dosage to twice a day instead of once. I love this drug and am so thankful to my doctor for prescribing it!! Hope things get better for those of you who are still suffering!”

10 / 10
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HK · April 8, 2021

For Endometrial Cancer: “I was on Megace for uterine cancer. I was diagnosed early with stage one uterine cancer when I was 34. I hadn’t had children yet and was hoping to conceive still. My doctor said we could try this medication before doing a hysterectomy since my cancer was a low grade. I was also in the middle of a weight loss journey so the side effect of weight gain freaked me out. I was on Megastrol for 6 months and beat uterine cancer with this drugs. Additionally, with a strong mental attitude, I was able to work out and lose weight on this medication and did not let myself over eat. I’m almost 36 now and currently pregnant with a baby girl. I was desperate for stories like mine, but couldn’t find any when I went through all of this. If you’re in a situation like me, don’t give up hope. You’ve got this!!”

10 / 10
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My miracle · Taken for 1 to 6 months · August 29, 2019

For Abnormal Uterine Bleeding: “Was on a straight period for 3 months, not just a regular period either. I went thru about 10-14 pads a day, and I had to double them so over 20 pads a day, heavy clots. I was white as a ghost, constantly sleeping. So I finally went to the hospital and they admitted me instantly. I had 3 blood transfusions within the first 24 hours being there, my level was a 3! I started the megace the next day and my period stopped that night. Well I just had a D&C done 4 days ago and I just started bleeding and cramping so bad. This medicine is amazing and I highly recommend it. But now I have to go back to the hospital tomorrow morning because my Dr is afraid of me losing to much blood, and I am having a partial hysterectomy (soon) . The megace actually made me loose 10lbs lbs within the first couple weeks! Also it's been 2 months I've been on the medication twice a day. I'll update after my hospital visit tomorrow.”

10 / 10
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Pdenn · December 14, 2019

For Abnormal Uterine Bleeding: “I'm going through perimenopause. I had a period for 11 months straight. I ended up in the ER hemorrhaging. I was given 10 units of blood. I was passing blood clots the size of basketballs. I thought I had cancer. They gave me a DNC preparing for a emergency hysterectomy. The DNC stopped it. Praise God. They sent me home with megastrol. It worked for a few weeks until my prescription ran out. My doctor put me back on it and I continued spotting. Nothing ever heavy. She kept changing my prescription 3 weeks on one week off. 2 weeks on 2 weeks off. I was getting frustrated it wasn't working. It wasn't causing any bad side effects. No weight gain. I felt great. At one point I bled a regular period for 72 days straight. My doctor was going to switch my medicine. Something told me to continue to stay on megastrol. Finally after being on the pill for 4 months. It finally worked and I'm 3 cycles of a normal period. So don't give up if it doesn't work right away.”

7 / 10
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Ame3 · August 25, 2010

For Abnormal Uterine Bleeding: “I began using this medicine after having very heavy bleeding for 2 month straight. My periods were pretty regular until then. I was in tears when I went to see my doctor. He gave me this pill and it stopped the bleeding within 1 day. It was great. Took it for about 5 days. It has now been 4 weeks and have not seen a sign of its return. I did not have any severe side effects on it except that I was a little emotionally edgy for about 3 days or so. I just kept to myself and made no important decisions for the week. Hope this helps.”

8 / 10
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Lovelyk86 · Taken for less than 1 month · September 6, 2018

For Abnormal Uterine Bleeding: “I was prescribed megestrol 40mg, 2 pills a day, after having a very heavy period for 3 months straight with tennis ball sized clots and horrific pelvic pain. I’m now on day two and the bleeding is almost non existent! I'm down to just some very light spotting. I will take the tummy ache, headache and gassy feeling over bleeding to the point of soaking through an ultra tampon and overnight pad in 30min. My hysterectomy will be my long term fix, but we had to stop the bleeding before the surgery. Can’t wait for October to permanently end periods once and for all.”

10 / 10
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Anonymous · August 22, 2019

For Abnormal Uterine Bleeding: “I have had a heavy period all month of August. I couldn’t take it any more and went to the doctor yesterday. She prescribed megestrol and I took it standing in the pharmacy it instantly stopped my flow and I am so thankful for this med”

10 / 10
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Too Thin · Taken for 1 to 6 months · July 11, 2012

For Weight Loss: “Been very thin all my life (high metabolism). I'm 40 & 5'5 weighing at 92 lbs. I was too thin and wanting to gain weight. A friend suggested Megace. I took 1 teaspoon 3 times a day. I gained 7 lbs in the first week. After 3 weeks I am up to 117lbs where I wanted to be. I feel and look much healthier. Con was my appetite was insatiable. I only wanted to eat ALL DAY. I always had food with me if I went out. I ended up with a food baby (that's what I call it) belly. I looked pregnant. That went away when I stopped taking it. It did stop my periods but when I'd stop taking it the periods would always return. It did make me very thirsty all the time as well. Other than that I love it! Take 1 tsp every other 2-3 days now to maintain the weight.”

10 / 10
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JulieinColorado · April 22, 2014

For Abnormal Uterine Bleeding: “I have large fibroids and had such heavy bleeding that I had to have a blood transfusion. I have been taking Megestrol for 7 months and it has reduced my period to just spotting for a few days. A God send, since my iron and blood levels have gone up to normal. I cut the dose in half to 200 mg/day and it still works. Unfortunately, I have experienced weight gain, depression, fleeting pains in my body, worsened vision, joint stiffness, and more susceptibility to Candida. On the higher dose (400mg/day), I had some spontaneous bruising and ankle swelling. I am having a hysterectomy soon and will stop using this but thankfully the benefits outweighed the risks for me--at least short term.”

8 / 10
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KD · November 7, 2019

For Abnormal Uterine Bleeding: “Feb 2017 I started having abnormal uterine bleeding. Huge clots, bright red blood. After 10 days of increased bleeding I saw my OB. I was put on Megestrol and told I needed a biopsy to clear out cancer. It was highly suggested that I get a Uterine Ablation . I did months later which did not work. I had to continue on the Megestrol. It did sometimes stop the bleeding in the very beginning but then from time to time I would get some very light bleeding. This summer I decided to stop taking the Rx to see what would happen. For about 2.5 months no bleeding and no pills! I was so excited and thought it was all behind me and then one day the blood showed up again. I tried not to panic and waited 2 days before resuming the pills. It's Nov 2019 and I am still having bleeding issues. It seems the Megestrol does not completely work anymore. I still bleed sometimes light and sometimes a little more. It's so frustrating to deal with this.”

8 / 10
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annaelxabeth · Taken for 1 to 6 months · February 9, 2022

For Weight Loss: “I was put on megestrol because I needed to gain some weight and I had very low appetite. I gained about 30 lbs in one month on 5 ml daily. My appetite was great. However I had some not so great side effects. My nose and mouth were very dry, my period never came, I had low energy and rapid breathing most of the time and developed what I believe is Cushing’s syndrome. My face BALLOONED up from moon face and I gained a significant amount of stomach weight. I have now been off the medication for about a week and most symptoms have resided still waiting on swelling to go down. But appetite is still good. Needed to be done. But side effects are brutal. I also had frequent urination and sweating when I would wake up. I also had difficulties staying asleep and falling asleep.”

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Alisha · Taken for 1 to 6 months · March 22, 2020

For Weight Loss: “The M.D at my former job put me on this medication because I’ve always been super thin, unable to get over 110 for some reason. I also have PCOS. And experience horrible periods however I started this medicine on 03/06/2020 and so far it has given me a serious appetite, and I can see a change in my weight to my face, stomach, thighs, and my butt. I’m not exactly sure how much weight as I don’t have a scale at home yet but I can certainly tell a difference. I also have not gotten my period which I was due for right after starting this medicine. No negative side effects yet, I absolutely am happy with results so far! Will keep my weight posted :)”

10 / 10
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K Ellen · Taken for 1 to 6 months · December 25, 2020

For Abnormal Uterine Bleeding: “Ive been on 40 mgs Megace a day for the last 3 months for endometrial hyperplasia. Im 61 years old. I'm not seeing any difference in bleeding. I had a constant period since I started and they are very heavy sometimes. I'm trying to tough it out until my next biopsy, but don't have high hopes. I've been more depressed since I've been on it too. I wish I could have the positive experience others have shared.”

1 / 10
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Bonnie-Lynn · March 4, 2009

Megace (megestrol) for Abnormal Uterine Bleeding: “I have been on Megace for the past three months. I have just finished it and have had no side effects at all except a little rash under my left breast line but that could also be the dry electrical heating as well but otherwise I haven't any breakthrough bleeding or weight gain or anything else. I go back to my doctor on March 20th, 2009 in two weeks and we will see what she says. I guess I went to her because of severe lower back aches and frequent bleeding as well as a lot of abdominal pain. I had no problems at all on Megace.”

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anna · October 16, 2018

For Weight Loss: “I'm 65 yr old female, for about a year I've been losing weight, no appetite, a couple bites and I'm full I never get hungry, I went a week ago to my primary care doctor I weighed 88 lbs my doctor wrote me a prescription for megestrol acet its been a week, I weighed myself after one week now I went from 88 lbs to 94 pounds my appetite is better . Wish I could heard of this medicine sooner, my goal is 120.00 thank god for my doc”

10 / 10
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Soulcr8 · January 26, 2012

Megace (megestrol) for Cachexia: “I've been down 3 surgeries in 11 months. Lost 60lbs and could not eat. I have been on Megace for 10 day's and I have gained 17 lbs. UNREAL! I have eaten $200 in groceries and have no plans to stop. MEGACE has beyond a doubt saved my life. Side effects are little to none. Dry mouth/more frequent urination/"Incredible appetite"! I am in it for the weight gain. Today I feel so good and strong, I caught myself running home from the store. ”

9 / 10
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Carm · December 8, 2019

For Abnormal Uterine Bleeding: “I've been experiencing extended cycles. I'm pretty proactive so when it lasts longer than 10 days I contact my gyn. She put me on provera which works well for the most part but sometimes spotting would return and when it's gone bleeding returns with a vengeance. Because of all that she put me on Megestrol to see if it works better. Last night was my first time. It worked quickly and the bleeding went from excessive to minimal. However, this morning full return. I've taken again and I'm waiting to see if it stops. I'm only on 20mg once a day so no side effects. I just really want the bleeding to stop and figure out why. I do have polyps and have had them removed but we suspect a return. Doing s biopsy then hopefully D&C or polypectomy. If anyone has any advice or input it's much appreciated. Thanks to all who shared. I don't want a hysterectomy. PCOS if also a high potential but no exact diagnosis”

8 / 10
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TaraGator · December 8, 2009

Megace (megestrol) for Endometrial Cancer: “I have been taking Megace, in conjunction with Xeloda for the past year to help treat my Stage 3 Ovarian Cancer. Since my tumor is estrogen feeding, this medication takes the estrogen out of my system. Tumors have CONSIDERABLY shrunk since I've been on this medication.”

10 / 10
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JayeD48 · April 24, 2016

For Abnormal Uterine Bleeding: “I had heavy bleeding for several years but within the last 3 years I ended up in the Hospital twice in which I had to get several Blood Transfusions. I have only 1 Fibroid the size of a dime. I've had an DNC and Ablation surgeries. I was prescribed Megestrol in January after leaving the Hospital. I was told to take 2 pills a day instead of 4. In February when menstrual came on it has not went off since, even though it is light. So I was told to take 4 a day, no change. I am getting tired of wearing pads everyday. The side effects are some mood swings, every night about 3 times I wake up drenched in sweat. I've gained over 20lbs. I really do not want a Hysterectomy, but it seems I have no choice.”

1 / 10
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Jeylady · Taken for 1 to 6 months · January 16, 2017

For Weight Loss: “I have been skinny all my life , but due some medical issues i lost some more weight and ended up at 95lbs (5'4). During my hospital stay a Nutritionist told me about Megace and said i can try it and see if it helps me. After I got out of the hospital I went to pick up the Medication and started it right away. I started by the end of November 2017 and gained over 27 lbs so far. I cant be happier.No side effects at all beside not getting my period. I definitely recommend MEGACE.”

10 / 10
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Cshells · May 13, 2020

For Abnormal Uterine Bleeding: “After 2 years of dandc, IV iron, and blood infusions on progesterone with no help, a fill in dr wrote me a script for megestrol. It changed my life. The other one made me emotional and unreasonable, carb craving and food obsessed all day every day to where I put on 20 lbs, bloat and gas and an odd smelling discharge. On this one I have stepped down to 10mg a day from 20mg 3 times a day and its changed my life. No bleeding, no mood swings, my appetite is back to normal and the bloat is gone. It's like I'm not taking a progesterone at all. I understand that if you quit taking it, the second time doesn't work as well so unless something drastic happens I'm staying on it.”

10 / 10
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Storm1204 · April 1, 2017

For Abnormal Uterine Bleeding: “I was prescribed this because of heavy bleeding with my period because of a fibroid. At first I was amazed because as soon as my period started I took them and it stopped within a few hours or a day. Then I started bleeding again after two weeks. I took it again. Two weeks later, spotting again. Now my period was heavy, but it was predictable before megace. The only time I was ever late was when I was pregnant. But now, its all over the place, when I don't take the megace at the start of bleeding, it will be nonstop. I've had a light period for the past two weeks! Doesn't work anymore and causes weight gain. I hate it.”

1 / 10
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A Rose by any other name · Taken for 1 to 2 years · February 10, 2015

Megace (megestrol) for Endometrial Hyperplasia: “This was by far the most horrible medication I've been on in my life. It did end the endometrial precancerous condition, but at great cost to my body and mind. The doctors also don't tell you it is a steriod. My side effects included: Joint pain everywhere - steriods eat away the joints over time High blood pressure - I didn't have it before this medication, and I do now Edema everywhere - including hands and face Hypoglycemia - had to drink orange juice and eat small meals to keep it under control. Nightmares and bad dreams - I never seemed to be able to get a deep sleep Fatigue Unable to truly experience joy or emotion except anger Emotionally brittle - had to lie down whenever I got upset (and more than this will allow me to type)”

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Anonymous · Taken for 1 to 6 months · June 8, 2012

For Abnormal Uterine Bleeding: “This medication has taken me on a roller coaster ride. I am over sensitive, moody, hypersensitive. I can't sleep and I have gained 8lbs in 30 days. It does control the bleeding but it is not worth putting up with the side effects.”

2 / 10
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Anonymous · Taken for 6 months to 1 year · November 12, 2016

For Abnormal Uterine Bleeding: “For several years, I have been experiencing very heavy and clot filled periods, sometimes lasting as long as 21 days (the heavy part would occur from day 2-4) and I was bleeding past super large tampons and pads every 30 minutes (I would wear both). I was also experiencing chest pains and shortness of breath, which forced me to the hospital a few times. There were no heart issues, however, I was severely anemic and received several blood transfusions, my lowest blood level being 5.4. An ultrasound determined that I have fibroids and was prescribed megastrol acetate and although I have light daily spotting and headaches, this is the best thing that has ever happened to me. When I do have a period, it's just slightly more than spotting.”

9 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.