Megestrol for Endometrial Hyperplasia User Reviews

• A...
• Taken for 1 to 2 years
• February 10, 2015

Megace (megestrol) "This was by far the most horrible medication I've been on in my life. It did end the endometrial precancerous condition, but at great cost to my body and mind. The doctors also don't tell you it is a steriod. My side effects included: Joint pain everywhere - steriods eat away the joints over time High blood pressure - I didn't have it before this medication, and I do now Edema everywhere - including hands and face Hypoglycemia - had to drink orange juice and eat small meals to keep it under control. Nightmares and bad dreams - I never seemed to be able to get a deep sleep Fatigue Unable to truly experience joy or emotion except anger Emotionally brittle - had to lie down whenever I got upset (and more than this will allow me to type)"

• Linda...
• Taken for 6 months to 1 year
• December 30, 2012

Megace (megestrol) "Took 20mgs. of Megase for 4 months then 10mgs. for another 3 months and had NO side effects whatsoever. (I actually managed to lose some weight while taking this medicine.) It took some time for my complex hyperplasia without atypia to clear up, but my latest biopsy was clear from all hyperplasias and now on a regime of 10mgs. of Provera and will go back for a follow up in another 2 months. (I was actually kind of worried to change to Provera as I did so well and had no negative side effects while taking the Megace.)"

• 60...
• October 8, 2013

"I have endometrial hyperplasia without atypia and my insurance refuses a hysterectomy. I have been on megestrol now for over 2 1/2 months. 40mgs twice a day. Hot flashes, insomnia and bleeding, BUT I have been shedding the excess tissue of my hyperplasia. I go back in 2 weeks for yet another biopsy and will see if the hyperplasia is gone. One other effect is very strong urine from this medicine. I had tried regular progesterone and I could not tolerate it. Major bleeding and egg sized clots. So far megesterol is working for me. Time will tell, but I am hopeful of being able to stop taking it."

• jademoe
• Taken for 10 years or more
• August 19, 2013

"I've been on Megestrol for a little over 10 years. Started with 40mg at first for about 6 years now down to 20mg. This medication worked great for the endometrial hyperplasia, however there are side effects. The side effects I noticed were my hair was falling out, I have a weaker stomach, low sexual desire (dosage was changed to 20mg). My hair came back but the others are still there. Comparing the side effects to it's effectiveness, I still take Megestrol as of today."

• mackka
• December 3, 2014

Megace (megestrol) "I took this after I had surgery on my ovaries. It gave me bad insomnia, hot flashes and really bad weight gain. Once I was off of it I was ok. I am once again on Megace for Hyperplasia and I am experiencing hot flashes and weight gain once again, but now within the month that I have been taking it my blood sugar is going up and I am fatigued all the time."

• T-oski
• July 30, 2009

Megace (megestrol) "At the six week point I began bleeding and have been bleeding heavily for two weeks. Also swelling of feet and ankles as well as a weird 'whooshing' sound in my ear. I think the Megestrol turned on me."

• Gemini
• March 25, 2018

"I was diagnosed with complex endometrial hyperplasia about 2 weeks ago. I actually ended up in the ER from bloodloss. I almost died. Had to have 4 blood transfusions. Had an emergency D&C and test came back complex endometrial hyperplasia. I've been on this medication 40 mg twice a day now for 2 weeks. The only things I'm experiencing are constipation, insomnia, mood changes. My dr wants me back in 3 months to do a biopsy and also get an IUD. In 3 months we will see how I'm doing. I hope it goes away because my fiance and I want to have a baby but everything has been put on hold until the dr gives is the 'okay'. I only gave 7 stars because I haven't been on it long enough or had a check up yet to see how its working. But for me its been pretty mild. -Gemini"

• Katydid
• August 6, 2016

"Began taking this medication in April and still on it in August. I was bleeding heavily for 5 months. A biopsy revealed Hyperplasia with atypia. This medication stopped my period but gave me intense night sweats, headaches, breast pain and weight gain. I'll be having a hysterectomy in September."

• PAano
• July 29, 2020

"I have been struggling with endometrial hyperplasia for about 5 years now. This is my first time sticking to my recommended dosage because my husband and I are trying to conceive. I definitely have cravings and find myself eating and not even hungry so it has been important for me to really get a grip on it and try intermittent fasting. My weight is a main cause of my condition I believe. Other symptoms I have experienced are very light, mild vaginal cramping. Usually like a throbbing feeling. This may happen randomly for a moment and then I might not feel anything for days. Some pelvic and abdominal cramping but again faint and not often. I have a few days of old blood discharge after my first month, 1 day of spotting into the 2nd month. Going into month 3 now. Im taking 40mg 2x a day and have a D&C at the end of Aug to follow up."

• LMD
• Taken for 1 to 6 months
• December 9, 2019

"This is my story, had failed IVF. Abnormal uterine bleeding from the last miscarriage, on and off menstrual period, not heavy at all. I technically not ovulating and rarely menstruate. June 2019, I went to see RE for water ultrasound to R/U polyps, and yes my suspicious was right. Polyps removed, found advanced hyperplasia grade 1, placed on Megace 160mg daily. First month, October 2019, no bleeding, second month November, started spotting, and I called my doctors and was told it was normal. Until today, 12/9/2019, I am spotting. No heavy flow or clots. I read an article that this medication regulates period of there was amenorrhea but for those who are menopausal. So, now I am unsure at my age of 42, I am menopausal. I am very confused"

• SNicole
• March 15, 2021

"I have been taking this for about 2 weeks for hyperplasia with atypia. I had not really had any side effects until last night when I begin to have these awful leg cramps that made my legs feel tight and weak. My heart begin to race, I couldn't sleep (insomnia), and I just started feeling overall bad. I sent my doctor a message and awaiting a response. If these are the side effects, I don't know if I can continue these meds. I am supposed to take 40mg once per day for 3 months."

• Still...
• Taken for 1 to 6 months
• September 25, 2017

"I was diagnosed with complex endometrial hyperplasia with atypia on 8/9/17 and began megestrol on 8/12/17. I slowly began experiencing common symptoms such as weight gain and increased appetite, but then I slowly started experiencing increased mood swings, irritability, insomnia, itchy body, and shortness of breath. What made me finally call the doctor on 9/19/17, was me being up at 3am with the inability to breath. I was informed to discontinue due to allergic reactions. On 9/21/17 I began with joint pain and swelling on my hands and wrists. By Friday, 9/22/17, I couldn't function for myself at all. My entire left arm and both hands were useless and I ended up in the ER where I learned this is all allergic reactions as well."

• Viano
• Taken for 1 to 6 months
• August 6, 2018

"I do not need to gain weight as a matter of fact I was already overweight and now I'm gaining even more . Can I take something that won't make me gain so much weight ?"