Skip to Content

User Reviews for Megestrol

Also known as: Megace, Megace ES

The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Learn more about Megestrol.

Filter by:

User Ratings


Megestrol Rating Summary

5.7/10 Average Rating

6 Ratings with 8 User Reviews

What next?Compare all 15 medications used in the treatment of Endometrial Hyperplasia.

Reviews for Megestrol to treat Endometrial Hyperplasia

"I was diagnosed with complex endometrial hyperplasia with atypia on 8/9/17 and began megestrol on 8/12/17. I slowly began experiencing common symptoms such as weight gain and increased appetite, but then I slowly started experiencing increased mood swings, irritability, insomnia, itchy body, and shortness of breath. What made me finally call the doctor on 9/19/17, was me being up at 3am with the inability to breath. I was informed to discontinue due to allergic reactions. On 9/21/17 I began with joint pain and swelling on my hands and wrists. By Friday, 9/22/17, I couldn't function for myself at all. My entire left arm and both hands were useless and I ended up in the ER where I learned this is all allergic reactions as well."


Still fighting precancer (taken for 1 to 6 months) September 25, 2017

0 users found this comment helpful.
Did you? Yes  No  |  Report inappropriate

"Began taking this medication in April and still on it in August. I was bleeding heavily for 5 months. A biopsy revealed Hyperplasia with atypia. This medication stopped my period but gave me intense night sweats, headaches, breast pain and weight gain. I'll be having a hysterectomy in September."


Katydid22 August 6, 2016

6 users found this comment helpful.
Did you? Yes  No  |  Report inappropriate

Megace (megestrol): "This was by far the most horrible medication I've been on in my life. It did end the endometrial precancerous condition, but at great cost to my body and mind. The doctors also don't tell you it is a steriod. My side effects included: Joint pain everywhere - steriods eat away the joints over time High blood pressure - I didn't have it before this medication, and I do now Edema everywhere - including hands and face Hypoglycemia - had to drink orange juice and eat small meals to keep it under control. Nightmares and bad dreams - I never seemed to be able to get a deep sleep Fatigue Unable to truly experience joy or emotion except anger Emotionally brittle - had to lie down whenever I got upset (and more than this will allow me to type)"

A Rose by any other name (taken for 1 to 2 years) February 10, 2015

26 users found this comment helpful.
Did you? Yes  No  |  Report inappropriate

Megace (megestrol): "I took this after I had surgery on my ovaries. It gave me bad insomnia, hot flashes and really bad weight gain. Once I was off of it I was ok. I am once again on Megace for Hyperplasia and I am experiencing hot flashes and weight gain once again, but now within the month that I have been taking it my blood sugar is going up and I am fatigued all the time."


mackka December 3, 2014

16 users found this comment helpful.
Did you? Yes  No  |  Report inappropriate

"I have endometrial hyperplasia without atypia and my insurance refuses a hysterectomy. I have been on megestrol now for over 2 1/2 months. 40mgs twice a day. Hot flashes, insomnia and bleeding, BUT I have been shedding the excess tissue of my hyperplasia. I go back in 2 weeks for yet another biopsy and will see if the hyperplasia is gone. One other effect is very strong urine from this medicine. I had tried regular progesterone and I could not tolerate it. Major bleeding and egg sized clots. So far megesterol is working for me. Time will tell, but I am hopeful of being able to stop taking it."

60 year old October 8, 2013

23 users found this comment helpful.
Did you? Yes  No  |  Report inappropriate

"I've been on Megestrol for a little over 10 years. Started with 40mg at first for about 6 years now down to 20mg. This medication worked great for the endometrial hyperplasia, however there are side effects. The side effects I noticed were my hair was falling out, I have a weaker stomach, low sexual desire (dosage was changed to 20mg). My hair came back but the others are still there. Comparing the side effects to it's effectiveness, I still take Megestrol as of today."


jademoe125 (taken for 10 years or more) August 19, 2013

20 users found this comment helpful.
Did you? Yes  No  |  Report inappropriate

Megace (megestrol): "Took 20mgs. of Megase for 4 months then 10mgs. for another 3 months and had NO side effects whatsoever. (I actually managed to lose some weight while taking this medicine.) It took some time for my complex hyperplasia without atypia to clear up, but my latest biopsy was clear from all hyperplasias and now on a regime of 10mgs. of Provera and will go back for a follow up in another 2 months. (I was actually kind of worried to change to Provera as I did so well and had no negative side effects while taking the Megace.)"


LindaJBU (taken for 6 months to 1 year) December 30, 2012

40 users found this comment helpful.
Did you? Yes  No  |  Report inappropriate

Megace (megestrol): "At the six week point I began bleeding and have been bleeding heavily for two weeks. Also swelling of feet and ankles as well as a weird 'whooshing' sound in my ear. I think the Megestrol turned on me."


T-oski July 30, 2009

25 users found this comment helpful.
Did you? Yes  No  |  Report inappropriate