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Megestrol User Reviews & Ratings (Page 2)

Brand names: Megace ES

Megestrol has an average rating of 7.3 out of 10 from a total of 135 reviews on Drugs.com. 63% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Megestrol

Commonly mentioned side effects
  • Anonymous
  • Taken for 1 to 6 months
  • June 8, 2012

For Abnormal Uterine Bleeding "This medication has taken me on a roller coaster ride. I am oversensitive, moody, hypersensitive. I can't sleep and I have gained 8 lbs in 30 days. It does control the bleeding, but it is not worth putting up with the side effects."

2 / 10
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  • Anonymous
  • Taken for 6 months to 1 year
  • November 12, 2016

For Abnormal Uterine Bleeding "For several years, I have been experiencing very heavy and clot-filled periods, sometimes lasting as long as 21 days (the heavy part would occur from day 2-4), and I was bleeding past super large tampons and pads every 30 minutes (I would wear both). I was also experiencing chest pains and shortness of breath, which forced me to the hospital a few times. There were no heart issues, however, I was severely anemic and received several blood transfusions, my lowest blood level being 5.4. An ultrasound determined that I have fibroids and was prescribed megestrol acetate, and although I have light daily spotting and headaches, this is the best thing that has ever happened to me. When I do have a period, it's just slightly more than spotting."

9 / 10
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38 Report
  • A...
  • Taken for 1 to 2 years
  • February 10, 2015

Megestrol for Endometrial Hyperplasia "This was by far the most horrible medication I've been on in my life. It did end the endometrial precancerous condition, but at great cost to my body and mind. The doctors also don't tell you it is a steroid. My side effects included: joint pain everywhere - steroids eat away the joints over time, high blood pressure - I didn't have it before this medication, and I do now, edema everywhere - including hands and face, hypoglycemia - had to drink orange juice and eat small meals to keep it under control, nightmares and bad dreams - I never seemed to be able to get a deep sleep, fatigue, unable to truly experience joy or emotion except anger, emotionally brittle - had to lie down whenever I got upset (and more than this will allow me to type)."

2 / 10
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  • Chu...
  • February 10, 2011

For Unintentional Weight Loss (Underweight) "I had a lung infection (emphysema and an abscess), and I had always had very low weight. I have had appetite problems all my life. During my illness, I was down to 104 lbs, after taking megestrol, I am now up to 154 lbs and am doing fine. I credit megestrol with saving my life. I still take 20 mg every day to keep my appetite going. What a great medicine."

9 / 10
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  • Lin...
  • Taken for 6 months to 1 year
  • December 30, 2012

Megestrol for Endometrial Hyperplasia "Took 20 mgs of Megace for 4 months, then 10 mgs for another 3 months and had NO side effects whatsoever. (I actually managed to lose some weight while taking this medicine.) It took some time for my complex hyperplasia without atypia to clear up, but my latest biopsy was clear from all hyperplasias and now on a regime of 10 mgs of Provera and will go back for a follow-up in another 2 months. (I was actually kind of worried to change to Provera as I did so well and had no negative side effects while taking the Megace.)"

10 / 10
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  • Lad...
  • January 8, 2016

For Abnormal Uterine Bleeding "I usually never write reviews, but this medicine was great!!! I had been bleeding for two months, heavy bleeding and clotting!!! Thought I was dying! Prior to the day I was prescribed this medicine, I woke up in a pool of blood. I ran to the bathroom to clean myself up, and blood clots started coming out. My boyfriend rushed me to emergency. I was weak and exhausted from losing so much blood over those two months. My blood levels were very low. Of course, they kept me. They started me on Megestrol, and my bleeding slowed down that day!! After going home, my bleeding was completely gone by day three. And didn't return. I just saw my OB and was inserted an IUD (Mirena). So far, it sucks!"

9 / 10
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  • Reb...
  • Taken for 1 to 6 months
  • June 18, 2018

For Abnormal Uterine Bleeding "Prescribed for heavy bleeding with large clots. Bleeding went on for 15 days, lowering my hemoglobin. I went to the E.R. and was administered 3 units of blood. Megace was the only thing to work to stop the bleeding. That being said, it has lowered my blood pressure significantly, caused stomach pain, insomnia, gas, and constipation. I am not comfortable using Megace, but it has stopped the bleeding. I do not like the medication and wish I could take something else."

8 / 10
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30 Report
  • Dj2...
  • October 21, 2016

For Unintentional Weight Loss (Underweight) "I had lost about 40 pounds before I started taking megestrol. I am a big eater, my body just never gained the weight. The doctors had tried other medications, but none of them worked. On Oct 13, 2016, I went to the doctor and she prescribed me the megestrol. I had lost too much weight. About 3 weeks later, I had a doctor's appointment and had gained about 10 pounds! I was so happy. I finished up the rest of my prescription and went for the checkup I was to have a month after taking it. The doctor was very pleased with the results. She wrote out another prescription with refills, and I plan to keep taking it. It is the only thing that has worked for me and is the generic form. Try it."

10 / 10
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  • blu...
  • January 15, 2017

For Abnormal Uterine Bleeding "Got to say that this medicine was worth it so much. I was put on megestrol 20 mg for 20 days, and I had no side effects to this medicine. I started taking it, and by the 5th day, the heavy bleeding had stopped. This is the second time being put on megestrol 20 mg. I know everybody has a different opinion on this medication, and for what it's worth, I'm happy with the outcome every single time."

10 / 10
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  • Csh...
  • May 13, 2020

For Abnormal Uterine Bleeding "After 2 years of D&C, IV iron, and blood infusions on progesterone with no help, a fill-in doctor wrote me a script for megestrol. It changed my life. The other one made me emotional and unreasonable, carb craving and food obsessed all day, every day, to where I put on 20 lbs, bloat and gas, and an odd-smelling discharge. On this one, I have stepped down to 10 mg a day from 20 mg 3 times a day, and it's changed my life. No bleeding, no mood swings, my appetite is back to normal, and the bloat is gone. It's like I'm not taking progesterone at all. I understand that if you quit taking it, the second time doesn't work as well, so unless something drastic happens, I'm staying on it."

10 / 10
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  • Car...
  • Taken for 1 to 6 months
  • November 3, 2018

For Abnormal Uterine Bleeding "I started this drug exactly 4 weeks ago for stage 1 endometrial cancer. I’ve gained 17 pounds, mostly water. Trouble breathing, wheezing terribly. 4 doctors agreed this was the only option, now they are pushing me off of the other since my side effects started. Vision is blurred, and headaches are terrible. I was healthier with the cancer. This drug is horrible. It can cause scar tissue in your lungs on top of so many other things. It’s a very dangerous drug. Be careful. Pulmonologist in 2 days to go for a CT scan with contrast. This drug should be taken very seriously. The ER doctor said it could very well be a blood clot, but still wouldn’t do the CT scan. Ugh! It’s frustrating. Good luck."

2 / 10
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  • CeC...
  • Taken for less than 1 month
  • March 29, 2019

For Abnormal Uterine Bleeding "Ever since I got on the Depo shot, I've had issues. I've been bleeding heavily for months, now have blood clots, and the amount of fibroids has increased. I started 40 mg of megestrol once a day a week ago. It definitely slows down the bleeding, but it seems to wear off. If I take it early in the morning, I have no issues all during the day, barely going through a tampon, but come nighttime, it's heavy again. I just emailed my doctor about this. Maybe I need to use it twice a day, although I don't like the idea of adding more of this chemical/hormone to my body so as to not cause a higher risk of side effects. I'm very much considering ablation or even hysterectomy to just be rid of it all, I am terrified though."

8 / 10
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  • Ser...
  • March 15, 2021

For Unintentional Weight Loss (Underweight) "My doctor started me on this medication on February 17, 2021, due to failure to gain weight. I am pleased to say that I went from 98.12 pounds to 115.8 as of today (a few days short of taking it for a month). The downfall I’ve noticed with this is that I have horrible insomnia, more agitated than normal, and my hot flashes are the worst! Other than that, it seems to be doing what it’s supposed to do. Has anyone else gained 5 lbs a week being on this medication? Does the weight stay after you stop taking this medication? I am currently taking 10 ml once a day."

7 / 10
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  • Aid...
  • Taken for 1 to 6 months
  • March 24, 2017

For Unintentional Weight Loss (Underweight) "Always been 80 lbs since high school. No appetite, always ate in small portions. Taken this medication before, but the 1st time I took it in 2011, I gained weight, but I also gained esophagus spasms from all the gorging I did, so it's now permanently a side effect, yay. I started taking it again on Feb 22, 2017, weighed in at 80.6 lbs, as of today, March 23, 2017, I'm weighing in at 100.4. I haven't taken it in 3 days to see if I can keep the appetite and use it when needed. It's a great weight gain, but there are side effects. Mine include no period, no sex drive, severe cold night sweats, hot flashes, the esophagus spasms, and swelling of arms and legs when active. These are the pros that some may consider cons-constantly hyper."

9 / 10
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  • Luc...
  • Taken for 1 to 6 months
  • September 8, 2018

For Abnormal Uterine Bleeding "I was taking Megestrol last month for bleeding associated with a fibroid. It worked perfectly. Bleeding stopped. I stopped taking it. Bleeding started back, I started taking it again. It's not working. I have a terrible stomach ache and gas."

5 / 10
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  • mar...
  • March 2, 2016

For Abnormal Uterine Bleeding "I was prescribed 20 mg Megestrol tablets by my gynecologist for heavy uterine bleeding. I was to take 2 tablets a day. By the finish of the first day, I had slowed down to almost nothing. I took one pill the next day, and my bleeding stopped. It did its job, but not without causing me chest pains and making me feel awful. After the three pills, I stopped taking it, and my bleeding has not returned nearly a week later. Chest pains stopped after I stopped taking it. My doctor told me to resume use if bleeding starts up again, pending testing to see why I'm bleeding."

8 / 10
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  • kat...
  • May 8, 2014

For Unintentional Weight Loss (Underweight) "I took this for weight gain. In the beginning, I took it every day for a month. I went from 80 lbs to 115 lbs in one month. I overdid it. So, I stopped taking it and would only take it when my appetite would subside and just take it for a week, and when I was hungry again, I would stop. I would keep the appetite (a normal one) for about a month before needing more. However, I am going to stop taking it. I have no sex life with hubby. I have almost no desire. I don't know if it's from the medicines. It also gives me chills pretty bad. I think it makes me very fatigued as well but not 100 percent. From all I have read, this medicine stops the production of testosterone, which is why."

7 / 10
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  • jus...
  • Taken for 1 to 6 months
  • August 27, 2018

For Unintentional Weight Loss (Underweight) "I dropped from 114 lbs in February to 97 lbs in July. My new doctor realized from my charts that I had gone from 110 to 97 in a week because of 'stress'; I am 39. Anyhow, the doc gave me Megestrol 20 mg, 4 a day to help me gain weight, and I went from 97 lbs to 123 lbs!! It's a miracle! Although the weight goes to my butt and thighs, my belly is huge also!! I am happy about my weight gain; I am 5'6. Soon I am going to have to start toning up because this belly is not attractive. But this medicine does work! It took about 2 weeks for me to see weight gain, and after that, it didn't stop. I eat everything and stay hungry. Also, I've dropped the dose to 2-3 a day."

10 / 10
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  • I...
  • Taken for less than 1 month
  • December 5, 2016

For Anorexia "I have been skinny all my life. My normal weight was always around 99 lbs. But in 2014, I started gaining weight while I was on mirtazapine. I reached 127 lbs at my highest, and I was more than happy. Unfortunately, I lost the weight again after being always sick. Two months ago, I started getting really sick again and got hospitalized about a month ago with six different diagnoses. My weight went under 96 lbs. I spoke to a nutritionist, and she told me about Megace and told me to ask my primary care doctor for it. After I got out of the hospital, I went to see my doctor, and he prescribed it for me. Best thing ever. I've been on it now for about two weeks, and my appetite is great. I'm now at 110 and want 20 lbs more. It works!!!!!"

10 / 10
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  • Aal...
  • Taken for less than 1 month
  • September 19, 2019

For Abnormal Uterine Bleeding "After heavy bleeding for 3 weeks, the doctor prescribed 40 mg megestrol, once a day, for 7 days. Bleeding did not fully stop, but it was light enough to resume daily activities comfortably. I experienced increased appetite, but I have been actually losing weight. Energy levels were fine - probably better since the bleeding decreased. I also experienced some restlessness and trouble sleeping, but that could be attributed to other medical concerns on my mind."

6 / 10
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  • Lil...
  • Taken for 6 months to 1 year
  • March 23, 2019

For Unintentional Weight Loss (Underweight) "I was diagnosed with stage 4 metastatic colon cancer on 8/7/2017. Surgery was performed on 8/25/2017 to remove the large cancerous mass. The cancer has spread to my liver. After completing chemotherapy in 2/2018, I went into remission in 3/2018. I was having problems gaining weight due to my lack of appetite after chemotherapy. I wanted help to find a way to increase my appetite. Megestrol was the answer to my prayers. I weighed 108 lb in July 2018. I spoke with my oncologist, and he agreed and called in a prescription. As of 3/23/2019, I currently weigh 140 pounds. I have eliminated white bread and white rice. I have decreased the amount of Megestrol I take. I am fortunate to not have issues with blood clots or heart problems. If you do, please consult with your doctor about the side effects from taking Megestrol."

10 / 10
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  • Por...
  • Taken for less than 1 month
  • March 22, 2017

For Abnormal Uterine Bleeding "About two weeks ago, I had to be hospitalized because I was bleeding severely, and my blood level (which I may be saying wrong) dropped down to 5.4. I had to have a blood transfusion, and they gave me several rounds of medication within two days to see what would stop the bleeding. The one that worked was the Megestrol 40 mg. It says to take 4 times daily, and my doctor wants me to take the medication until my next appointment, which is 04/04/2017. I stopped bleeding the day that they gave it to me, and for about two days, I took as instructed, and now I take one pill every other day from fear that if I stop completely, the bleeding may come again. So far, I have not had any issues, and I've been taking it for about 2 weeks now."

10 / 10
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20 Report
  • Che...
  • Taken for 1 to 2 years
  • October 3, 2019

For Unintentional Weight Loss (Underweight) "I was on Megace for over a year. Worked well for me at first. Gained a lot of weight rapidly. I ended up having the side effects after long-term use, and my adrenal glands became suppressed. I was sick for a few months after that and lost some of the weight I gained."

4 / 10
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  • jad...
  • Taken for 10 years or more
  • August 19, 2013

For Endometrial Hyperplasia "I've been on Megestrol for a little over 10 years. Started with 40 mg at first for about 6 years, now down to 20 mg. This medication worked great for the endometrial hyperplasia, however, there are side effects. The side effects I noticed were my hair was falling out, I have a weaker stomach, low sexual desire (dosage was changed to 20 mg). My hair came back, but the others are still there. Comparing the side effects to its effectiveness, I still take Megestrol as of today."

10 / 10
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  • cha...
  • August 12, 2018

"Okay, so my doctor put me on megestrol only after putting me on progesterone for bleeding. The progesterone made me bleed like a stuck pig, so she moved me to megestrol, or rather, progesterone. The bleeding stopped for 2 to 3 weeks, so 'hello love life, I'm a happy girl.' Just have to wait to see how much it has worked as far as my hyperplasia situation. Hopefully, I won't need a hysterectomy. Anyway, for the past couple of weeks, the bleeding came back like a light. So 'goodbye love life,' and with it came heavy period pain. It was almost like I was ready to give birth, that's how bad the cramping is. My doctor said she has 'no idea why' I'm cramping because this is not a side effect. I know there's more women out there who have the same experience I have had. Does anybody else feel like a goddamn guinea pig?"

1 / 10
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