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Clonidine Pregnancy and Breastfeeding Warnings

Clonidine is also known as: Catapres, Catapres-TTS, Clonidine ER, Duraclon, Jenloga, Kapvay, Nexiclon XR

Medically reviewed on March 23, 2018.

Clonidine Pregnancy Warnings

Animal studies have failed to reveal evidence of teratogenicity although an increased incidence of fetal resorption has been demonstrated. There are limited controlled data in human pregnancy. This drug passes the placental barrier and may lower the heart rate of the fetus. A transient rise in blood pressure in the newborn cannot be excluded postpartum.

AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

This drug should be used during pregnancy only if the benefit outweighs the risk.

AU TGA pregnancy category: B3
US FDA pregnancy category: C

Comments:
-If this drug is used during pregnancy careful monitoring of mother and child is recommended.

See references

Clonidine Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Excreted into human milk: Yes

Comments:
-Concentrations of this drug in human breast milk are approximately twice those found in maternal plasma.
-Other drugs may be preferred, especially while nursing a newborn or preterm infant, due to possible infant side effects and negative effects on lactation.

See references

References for pregnancy information

  1. "Product Information. CloNIDine Hydrochloride (cloNIDine)." Unichem Pharmaceuticals Inc, New Rochelle, NJ.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Cerner Multum, Inc. "Australian Product Information." O 0

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. "Product Information. CloNIDine Hydrochloride (cloNIDine)." Unichem Pharmaceuticals Inc, New Rochelle, NJ.
  4. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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