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Estradiol / progesterone and Weight Gain: What Users Say

Brand names: Bijuva

Weight gain: mentioned by 7 users (14.9%)

Based on user experiences from 47 Estradiol / progesterone reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

weight gain 14.9%
hot flashes 12.8%
brain fog 8.5%
cramps 8.5%
heart palpitations 8.5%
bloating 6.4%
headaches 6.4%
irritability 6.4%
nausea 6.4%

Reviews for Estradiol / progesterone

Commonly mentioned side effects
  • Con...
  • Taken for 1 to 6 months
  • November 5, 2020

For Menopausal Disorders "I have just stopped this drug Bijuva. Took it for 4 months, and it did help greatly with my menopause issues. Then, about a month ago, I began feeling unwell. Headaches, fatigue, tension, weight gain, and even had a TIA at work! I almost died. The ER did every test they could think of... CAT, MRIs, heart scans, bloodwork, heavy metal tests, vitamin levels, thyroid, hormones, etc... Perfectly healthy! I still have brain fog, a constant headache, weakness, and moments of nausea and faintness. I truly have no idea if it is Bijuva, but I am not taking any chances."

4 / 10
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34 Report
  • Rob...
  • Taken for 1 to 6 months
  • July 21, 2021

For Postmenopausal Symptoms "I have been taking this medication for about 6 weeks, and while my hot flashes have stopped and I have just started sleeping through the night for the most part, over the last few weeks I have been gaining a pound, it seems almost daily, and have been retaining water, with some swelling to my feet. Also, I developed relentless GERD about 5 days ago that includes a metallic taste that seems to be coming from my throat. I am going to stop this medication, as I feel these issues are somehow related, and the weight gain itself makes it not worth it to me. I work really hard with diet and exercise, and that part is stressing me out."

6 / 10
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25 Report
  • Sle...
  • Taken for 2 to 5 years
  • May 19, 2021

For Postmenopausal Symptoms "I have been on Bijuva for 2 years. I decided on HRT because I couldn't take the hot flashes, mood swings, and brain fog any longer! I literally thought I was going crazy. I'm 48 and dealt with perimenopause effects for 10+ years. At 45, I was told I was postmenopausal. I started with meds from a compounding pharmacy. It worked for a while and stopped. The progesterone pearls kept me wide awake at night. Anyway, Bijuva has been a lifesaver for me. I still cramp and feel bloated, but all the other things are gone. I recently noticed a little weight gain, which is huge to me. I will be looking further into things. Good luck to all in this journey."

10 / 10
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24 Report

See also:

Frequently asked questions

  • jul...
  • Taken for 6 months to 1 year
  • January 9, 2023

For Perimenopausal Symptoms "I have been taking Bijuva for 6 months, it has helped hot flashes, joint aches, libido, and sleepless nights. The downside is I have gained weight, and I have had two episodes of quite heavy bleeding (the blood is clotted). I feel we are all guinea pigs at this time, as the doctors do not know the answers. I am not continuing with Bijuva."

4 / 10
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13 Report
  • Anonymous
  • September 10, 2020

For Menopausal Disorders "I have been taking Bijuva for four months now and starting to put things together on how I feel. It did help with the hot flashes, and in the beginning, I was sleeping through the night, but that has now stopped, so I have been overtired. I have put on weight. I am having daily nausea. I swear my memory is off, and today I went to the doctor since I have a small hernia, and he said he's concerned for my gallbladder, which is one of the worst side effects. I am stopping immediately."

2 / 10
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21 Report

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  • Na ...
  • Taken for 1 to 2 years
  • March 13, 2022

For Menopausal Disorders "Bijuva was perfect!!! I tried two other kinds before the Bijuva, and I didn't like them as they caused weight gain and yucky breast pain. So I got the Bijuva and was happy for a year, in fact, I lost weight on it as well, but then suddenly my doctor prescribed me Climara out of nowhere."

10 / 10
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7 Report
  • Ano...
  • Taken for 1 to 6 months
  • May 3, 2025

For Perimenopausal Symptoms "I have been taking Bijuva for 5 months now. At first, I was very excited as my night sweating stopped almost immediately, and I had been sleeping so well. Pain during intercourse was gone too. However, I have been gaining weight and lately feel sleepy during daytime as well. My stomach feels upset once in a while, and I am moodier than before. So I am thinking to stop taking it and hope that the night sweats won’t come back."

6 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.