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Medications for Opiate Withdrawal

What is Opiate Withdrawal:  Opiate withdrawal is an acute state caused by cessation or dramatic reduction of use of opiate drugs that has been heavy and prolonged (several weeks or longer).

Opiates include heroin, morphine, codeine, Oxycontin, Dilaudid, methadone, and others. The reaction frequently includes sweating, shaking, headache, drug craving, nausea, vomiting, abdominal cramping, diarrhea, inability to sleep, confusion, agitation, depression, anxiety, and other behavioral changes.

Medications to treat Opiate Withdrawal

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
methadone Rx C 2 X 182 reviews
8.0

Generic name: methadone systemic

Brand names:  Methadose, Dolophine, Methadone Diskets

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Robaxin Off Label Rx C N X 6 reviews
6.0

Generic name: methocarbamol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
clonidine Off Label Rx C N X 160 reviews
8.0

Generic name: clonidine systemic

Brand names:  Catapres, Catapres-TTS

Drug class: antiadrenergic agents, centrally acting

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Catapres Off Label Rx C N X 25 reviews
8.0

Generic name: clonidine systemic

Drug class: antiadrenergic agents, centrally acting

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
Methadose Rx C 2 X 20 reviews
8.0

Generic name: methadone systemic

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
methocarbamol Off Label Rx C N X 21 reviews
7.0

Generic name: methocarbamol systemic

Brand names:  Robaxin, Robaxin-750

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Dolophine Rx C 2 X 5 reviews
9.0

Generic name: methadone systemic

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Methadone Diskets Rx C 2 X 17 reviews
9.0

Generic name: methadone systemic

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

 
Robaxin-750 Off Label Rx C N X 4 reviews
7.0

Generic name: methocarbamol systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

Off Label: Yes

 
Thorazine Rx N N X Add review
4.0

Generic name: chlorpromazine systemic

Drug class: phenothiazine antiemetics, phenothiazine antipsychotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph

 
Catapres-TTS Off Label Rx C N X 3 reviews
8.0

Generic name: clonidine systemic

Drug class: antiadrenergic agents, centrally acting

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
chlorpromazine Rx N N X 2 reviews
7.0

Generic name: chlorpromazine systemic

Brand name:  Thorazine

Drug class: phenothiazine antiemetics, phenothiazine antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
chlordiazepoxide Off Label Rx N 4 X 3 reviews
7.0

Generic name: chlordiazepoxide systemic

Drug class: benzodiazepines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 

Learn more about Opiate Withdrawal

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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