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Methadone Drug Interactions

A total of 1145 drugs are known to interact with methadone.

  • 449 major drug interactions
  • 679 moderate drug interactions
  • 17 minor drug interactions

Show all medications in the database that may interact with methadone.

Check for interactions with methadone

Type in a drug name and select a drug from the list.

Common medications checked in combination with methadone

Methadone alcohol/food interactions

There are 2 alcohol/food interactions with methadone

Methadone disease interactions

There are 16 disease interactions with methadone which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.