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Methadone Drug Interactions

A total of 1135 drugs (6188 brand and generic names) are known to interact with methadone.

  • 446 major drug interactions (2083 brand and generic names)
  • 672 moderate drug interactions (4043 brand and generic names)
  • 17 minor drug interactions (62 brand and generic names)

Show all medications in the database that may interact with methadone.

Check for interactions with methadone

Type in a drug name and select a drug from the list.

Common medications checked in combination with methadone

methadone alcohol/food Interactions

There are 2 alcohol/food interactions with methadone

methadone disease Interactions

There are 16 disease interactions with methadone which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.