Methadone Interactions
There are 837 drugs known to interact with methadone, along with 16 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 420 are major, 407 are moderate, and 10 are minor.
- View all 837 medications that may interact with methadone
- View methadone alcohol/food interactions (1)
- View methadone disease interactions (16)
Most frequently checked interactions
View interaction reports for methadone and the medicines listed below.
- Abilify (aripiprazole)
- Adderall (amphetamine / dextroamphetamine)
- Ambien (zolpidem)
- Ativan (lorazepam)
- Benadryl (diphenhydramine)
- Cymbalta (duloxetine)
- Dilaudid (hydromorphone)
- Flexeril (cyclobenzaprine)
- Klonopin (clonazepam)
- Lasix (furosemide)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- MiraLAX (polyethylene glycol 3350)
- Neurontin (gabapentin)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- OxyContin (oxycodone)
- Phenergan (promethazine)
- Prilosec (omeprazole)
- Prozac (fluoxetine)
- Seroquel (quetiapine)
- Soma (carisoprodol)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- Valium (diazepam)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
Methadone alcohol/food interactions
There is 1 alcohol/food interaction with methadone.
Methadone disease interactions
There are 16 disease interactions with methadone which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
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- Latest FDA alerts (5)
- Side effects
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- Drug class: Opioids (narcotic analgesics)
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Acetaminophen
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Oxycodone
Oxycodone is an opioid analgesic used to treat moderate to severe pain; it has a high potential for ...
Amvuttra
Amvuttra is used to treat polyneuropathy associated with hereditary transthyretin-mediated ...
Hydroxyzine
Hydroxyzine is an antihistamine used to treat itching, hives, and anxiety. It also acts as a ...
Tramadol
Tramadol is an opioid medication that may be used to treat moderate to moderately severe chronic ...
Cyclobenzaprine
Cyclobenzaprine is a muscle relaxant and works by blocking pain sensations. Includes ...
Duloxetine
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant used to ...
Meloxicam
Meloxicam is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Aspirin
Aspirin is used to treat mild to moderate pain and to reduce fever or inflammation. Learn about ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
