Methadone Alternatives Compared
| Methadone | Clonidine | Methocarbamol |
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| Methadone | Clonidine | Methocarbamol |
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Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Prescription only
Clonidine can be used to lower blood pressure and extended-release forms are used to treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects... View more |
Prescription only
Methocarbamol is only given when other treatments for musculoskeletal pain have not worked. Its main side effect is drowsiness and it should not be used in children or seniors. Prescribed for Opiate... View more |
Related suggestions |
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| More about Methadone | More about Clonidine | More about Methocarbamol | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Methadone has an average rating of 8.7 out of 10 from a total of 606 ratings on Drugs.com. 84% of reviewers reported a positive effect, while 6% reported a negative effect. |
Clonidine has an average rating of 7.2 out of 10 from a total of 775 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
Methocarbamol has an average rating of 6.4 out of 10 from a total of 299 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Methadone side effects |
View all Clonidine side effects |
View all Methocarbamol side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Methadone prices |
View all Clonidine prices |
View all Methocarbamol prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Methadone Diskets, Methadose, Methadose Sugar-Free | Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | Carbacot, Robaxin, Tanlor | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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30 hours |
15 hours |
2 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 837 drugs are known to interact with Methadone:
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A total of 375 drugs are known to interact with Clonidine:
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A total of 346 drugs are known to interact with Methocarbamol:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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August 13, 1947 |
September 03, 1974 |
July 16, 1957 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient Resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.