Skip to main content

Methocarbamol Disease Interactions

There are 2 disease interactions with methocarbamol.


Methocarbamol (parenteral) (applies to methocarbamol) renal dysfunction

Major Potential Hazard, Moderate plausibility.

The injectable formulation of methocarbamol is contraindicated for use in patients with impaired renal function due to the nephrotoxic potential of polyethylene glycol (PEG) 300 present in the vehicle. Quantities of PEG 300 much greater than that found in recommended doses of injectable methocarbamol have increased preexisting acidosis and urea retention in patients with renal impairment.


  1. "Product Information. Robaxin (methocarbamol)." Whitehall-Robbins

Methocarbamol (parenteral) (applies to methocarbamol) seizures

Moderate Potential Hazard, Moderate plausibility.

Seizures have occurred during the intravenous administration of methocarbamol. In some cases, the patient had a known history of epilepsy, and the psychic trauma of the procedure may have been a contributing factor. Nevertheless, therapy with the injectable formulation of methocarbamol should be administered cautiously in patients with a history of epilepsy.


  1. "Product Information. Robaxin (methocarbamol)." Whitehall-Robbins

Methocarbamol drug interactions

There are 327 drug interactions with methocarbamol.

Methocarbamol alcohol/food interactions

There is 1 alcohol/food interaction with methocarbamol.

Report options

Share by QR Code
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.