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Methocarbamol Disease Interactions

There are 2 disease interactions with methocarbamol:


Methocarbamol (Parenteral) (Includes Methocarbamol) ↔ Renal Dysfunction

Severe Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

The injectable formulation of methocarbamol is contraindicated for use in patients with impaired renal function due to the nephrotoxic potential of polyethylene glycol (PEG) 300 present in the vehicle. Quantities of PEG 300 much greater than that found in recommended doses of injectable methocarbamol have increased preexisting acidosis and urea retention in patients with renal impairment.


  1. "Product Information. Robaxin Injectable (methocarbamol)." Whitehall-Robbins, Madison, NJ.

Methocarbamol (Parenteral) (Includes Methocarbamol) ↔ Seizures

Moderate Potential Hazard, Moderate plausibility

Applies to: Seizures

Seizures have occurred during the intravenous administration of methocarbamol. In some cases, the patient had a known history of epilepsy, and the psychic trauma of the procedure may have been a contributing factor. Nevertheless, therapy with the injectable formulation of methocarbamol should be administered cautiously in patients with a history of epilepsy.


  1. "Product Information. Robaxin Injectable (methocarbamol)." Whitehall-Robbins, Madison, NJ.

methocarbamol drug Interactions

There are 701 drug interactions with methocarbamol

methocarbamol alcohol/food Interactions

There is 1 alcohol/food interaction with methocarbamol

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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