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User Reviews for Zanaflex

Condition Avg. Rating Reviews Compare
Muscle Spasm  
94 reviews 50 medications
Cluster Headaches  Off-label
6 reviews 36 medications

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Zanaflex

Hazel · Taken for less than 1 month April 23, 2021

For Muscle Spasm: “Doesn’t help my lower back pain at all. Take 4mg every 8 hours, cannot tell any difference.”

1 / 10
Anonymous January 31, 2021

For Muscle Spasm: “1/10”

1 / 10
Catz · Taken for 10 years or more November 20, 2020

For Muscle Spasm: “I have been taking 4mg Zanaflex for years after a terrible car accident. After trying other muscle relaxers I can say this one is the best for me. Make sure you are ready for bed because you will go to bed. It does not make you groggy in the morning.”

10 / 10
Rin February 26, 2020

For Muscle Spasm: “I have been on this medication Zanaflex for a few months due to degenerative disc disease in my neck, spine and lower back...I also have arthritis in my neck and back with severe muscle spasms. This medicine has helped me so much. It's not addictive and not a controlled substance which is fantastic. I wont take pain pills....I take 4mg 3 times a day and it helps me sleep.”

10 / 10
Star · Taken for 10 years or more October 18, 2019

For Muscle Spasm: “I have been on this medication Zanaflex for 17 years, it has always helped, I've never developed a tolerance to it. It does put me to sleep but with my condition I need to rest. I have yet to find a drug that does what this drug does. I have tried flexerill, robaxin and baclofen none of them do what zanaflex does”

10 / 10
southernbeauty · Taken for 1 to 6 months October 4, 2013

For Muscle Spasm: “Zanaflex has really helped me. I had major hip surgery last year and have had a very difficult time bouncing back. After the surgery I became very weak, lost significant amounts of muscle definition and tone, which resulted in a weakened lower back and core. I now live in excruciating pain, my L5 & S1 has completely compressed with my sciatic nerve in the middle. I have extreme nerve pain, and hypersensitivity down my right leg. Daily chores are very difficult, and my love for fitness now feels like a daunting chore. My doctor switched me from Soma to Zanaflex. At first I didn't like it because it made me extremely drowsy and would knock me out. Now I am used to the side effects and can honestly say that this medication is the best muscle relaxer I have ever taken. It reduces back pain, loosens up the tightness, and compliments my oxycodone very nicely. I can finally "function" again, and exercise, lift weights, and do my daily duties as a house wife & mother.”

10 / 10
Hailan · Taken for less than 1 month May 3, 2019

For Muscle Spasm: “I just started on zanaflex and I've never experienced such an effective muscle relaxer. I have MS and get really painful spasms and cramps. Have been on Baclofen for years (which hasn't been particularly helpful) and have also tried flexeril and skelaxin, which also did nothing. After taking the zanaflex, I actually felt my muscles relaxing (imagine that!) and could feel blood moving/tingling through my system. Was wonderful. The only problem is that, as others have said, it makes you REALLY drowsy, so I can't take the recommended 4mg dose 3x a day. I'm taking a quarter tablet twice in the daytime and then a full tablet late in the evening when I'm winding down for bed. I will also note that I had been assuming that the occasional slurred speech I was experiencing was a sign of my worsening MS, and now I'm reading reviews showing that Baclofen sometimes does that (!). So, I'm eager to get off that for a bit and see if this might be a better option for me long-term.”

9 / 10
Joshua Tree · Taken for 1 to 2 years October 5, 2016

For Muscle Spasm: “I just had L5-S1 Lumbar Herniated Disc Surgery.. 3 weeks after the surgery, I started leaning to the left due to fluid infection surrounding the disc.. My Dr gave me Oxycodone and Tizanidine for the excruciating pain.. Tizanidine / Zanaflex is definitely a 10 when it come to Sciatica and Spasms! Only lasts 3-4 hours, but it works best when combined with pain meds.. Hope y'all find this helpful..”

10 / 10
LAFS · Taken for 10 years or more April 4, 2014

For Muscle Spasm: “I have Multiple Sclerosis and was excited to begin Zanaflex as soon as it was approved in 1996. I had studied it for quite some time as it was in use in 47 countries before the US. I Love it and have had great results to this day with it. I'm not sure if it is very well presented or explained to patients; however, this is a very unique skeletal muscle relaxant & it actually targets the actual nerves of the patient. When you begin treatment it is important to note that for the 1st 2-3 weeks it is taking effect in your system. Great medicine!”

10 / 10
Old Grandma · Taken for 6 months to 1 year October 15, 2017

For Muscle Spasm: “I am a retired nurse and was in a near fatal MVA several years ago putting an end to my career of nursing. I broke many bones and had to have some bones pieced together with screws and steel plates. My overall health is good but mobility issues were a problem as I had gained a lot of weight because of my activity level was severely decreased. I became severely depressed, couldn't sleep because the pain was so severe and only worsened as time went by. I couldn't use my hands at times because the spasms would be so bad that I at times was dropping items of whatever I was holding in my hands. My legs cramped so bad at night that it was almost impossible to get adequate sleep, My doctor started me then on Zanaflex. It has helped tremendously .”

Maggie August 9, 2020

For Muscle Spasm: “I am prescribed this for neck spasms that cause debilitating chronic headaches and migraines. I read reviews on here that terrified me. This drug does make you feel a little weird the first time you take it, but it's not that serious. Don't skip trying it just because of scary reviews online. I try not to take it everyday. I am prescribed 2mg up to 3 times a day but I only take one. I have definitely noticed my number of headache days go down dramatically. I used to have them for up to 4 days in a row and over 15 days a month. My neck still hurts extremely bad. I believe that the zanaflex is relaxing the muscles on my scalp and face which stops most headaches from occuring. But as I said my neck is still bad me. It's better than having neck pain and severe headaches almost every day. But I'm going to ask my doctor for another treatment to help my neck. Ibuprofen doesn't cut it and I'm not supposed to take it everyday as I am susceptible to ulcers.”

6 / 10
CaDomino · Taken for 6 months to 1 year August 25, 2018

For Muscle Spasm: “I have severe muscle spasms in my neck. My doctor prescribed this when I was in her office in total agony. It was like heaven. I take 4mg tabs, but I can't do 3x a day, so I break one in half if needed, but I feel so good when I wake up. This drug has made a world of difference in my life.”

10 / 10
dailey61 · Taken for 10 years or more March 30, 2015

For Muscle Spasm: “I first was given Zanaflex about 14 years ago. I had had lower back surgery and some time later started taking it for muscle spasms, with me not playing with muscle relaxers, afraid of damaging my heart, because your heart is a muscle..therefore, I'm real careful with taking relaxants. I love it, it helps alot..and since I'm much older, I'm even more careful. But recently I was in a car accident and hurt my neck and my left shoulder, I was given robaxin which is a skeletal relaxer/ muscle really helps with this new pain. But, I'm not taking the zanaflex and the robin for now. I give zanaflex a ten. It works Great! Hope I was able to help someone.”

10 / 10
crazydude81 · Taken for less than 1 month October 19, 2018

For Muscle Spasm: “It works well to relieve pain, but at the cost of an astronomical exhaustion. This drug makes me so tired that walking to the fridge is a tremendous task. I could sleep on the floor. Probably the most effective muscle relaxer I've taken, but my quality of life - even 24 hours later - is nil.”

6 / 10
DinFlorida April 30, 2008

For Muscle Spasm: “I have severe herniated discs in my lower back and FINALLY a drug that helps. Percocet is great for getting through the day with pain, but Zanaflex helps me sleep pain free all night and my back is no longer stiff with pain in the morning. I only take it at night about 2mg or 4mg depending on pain and sleep like a baby. This after 10yrs of suffering with chronic back pain. I am new to this drug about 2months now.. crossing fingers it will work”

10 / 10
joyce · Taken for 1 to 6 months May 2, 2013

For Muscle Spasm: “I have chronic pain from several herniated discs and spinal stenosis. I also have fibromyalgia. I began taking Zanaflex last month and the relief is wonderful. I no longer hurt and spasm all night and now I can sleep instead. I take 4mg tabs 2 at bedtime and go immediately to bed as it makes me drowsy right away and I become dizzy if I stay up. I wake up rested with no hangover at all and feel good the next day. I take narcotics during the day for pain relief and the addition of this to my regimen is great. I love it.”

10 / 10
egg plant · Taken for 5 to 10 years April 22, 2015

For Muscle Spasm: “I've been on these for about 8 years. They work good on low back pain, DJD and bulging disc on my neck. Along with other pain killers it works good, but don't drive while on them. They do make you sleepy fast and also they tend to lower your blood pressure and you will get dizzy standing up. You can get a good night sleep on them. I take one 4 mg 2 times a day.”

9 / 10
Lilspark77 July 19, 2014

For Muscle Spasm: “After a bad car accident I've been prescribed several medications all of which had side effects that made them not possible to function with. Zanaflex is great, it starts working in about an hour after ingestion, it does make me sleepy so I take it one hour before bed and have a wonderful sleep. I wake up with out any grogginess the next morning. The only reason I didn't rate it a 10 is that if I took it during the day I would be drowsy.”

9 / 10
O.Lou · Taken for 1 to 2 years May 3, 2014

For Muscle Spasm: “I found this to be a wonderful muscle relaxant with very few, if any, negative side effects. It worked well for me during many bouts of chronic back pain that kept me awake at night. It did make me a little bit sleepy and dizzy, but nothing that bothered me very much at all. At night, this wasn't even a concern, but I could easily take it during the day at work and perform and feel fine. This isn't exactly a "pain" medication but I did find that it worked almost as well for my particular back pain as the narcotic medicines I was also prescribed.”

8 / 10
MonkeyTech January 5, 2016

For Muscle Spasm: “I have been taking zanaflex for about 2 years. The best thing about this medicine is it helps me sleep and for me there is no grogginess in the morning. I'm totally alert. Not like with other muscle relaxants. However the medicine usually last about 3-4 hours so it's quite common to wake up in the middle of the night. I give it an 8 because it does work really well for me however I wish the effects would last a little longer to get a full nights rest and also because I can't take it in the day because it knocks me out.....cold.”

8 / 10
kalopa.lady October 27, 2009

For Muscle Spasm: “I have used this medicine along with narcotic pain killers for a cervical disc protrusion. When I weaned off the pain killers, the Zanaflex really helped with the withdrawal symptoms (RLS, anxiety, sleeplessness) I was experiencing. This medicine still helps with the muscle spasms I get and it doesn't make me tired either, probably due to the high tolerance levels I have from years of abuse, however it really saved me during the Norco withdrawals - and have been off all narcotics for a few months now.”

10 / 10
Turkey · Taken for 6 months to 1 year September 6, 2012

For Muscle Spasm: “Zanaflex is great for muscle spasms as I have them from Osteoarthritis in my spine, also spinal stenosis. If you are on any heart meds, please use the interactions checker because it may cause severe drops in blood pressure. I am taking Lisinopril, Hydrochlorothiazide and Metoprolol for heart arrhythmias and my blood pressure was dropping to dangerous levels. All of my specialists knew what medicines I was taking, but none of them noticed the interactions. I checked them myself here at and found the RED FLAGS myself, so be careful.”

7 / 10
Tater · Taken for 1 to 2 years August 10, 2018

For Muscle Spasm: “I've been on this medication for about a year now I'm prescribed 4mg three times a day. I can't take the whole 4mg during the day or else I'll be to sedated so I break it in half. It has worked well for me especially when I can't sleep and I take a whole dose. I try not to take it everyday so I keep a low tolerance to it. I have fibromyalgia along with other health issues.”

6 / 10
PastorCindy · Taken for 10 years or more July 27, 2017

For Muscle Spasm: “I have been taking Tizanadine for 10 yrs. for severe muscle spasticity in neck and back due to RSD/CRPS, plus spinal stenosis, bulging discs, and previous car accident neck and spine injuries. Dose: 4 mg, 3 daily, usually 4 mg in the morning and 8 mg at night. I have found it very helpful. At first, it was very sedating, but not after a year or so. It does help me sleep. Works best with the help of pain meds and Baclofen cream. I had a serious drug interaction with SSRI antidepressants (particularly Luvox): actually passed out in my soup at a restaurant the first time I took them together. Hope this helps.”

Belinda36203 · Taken for 6 months to 1 year January 17, 2015

For Muscle Spasm: “I was prescribed Zanaflex for muscle spasms and to help me sleep. I have been diagnosed with fibromyalgia, osteo/degenerative arthritis, sciatica, and an unspecified autoimmune disorder. It was prescribed as 3-4mg tablets at bedtime but that was too high a dose for me. Sometimes, I have the side effect of really low BP, although I have been taking HIGH BP meds for 5+ years. It doesn't happen all the time (when I take it) but it is very scary when it does happen. I have black outs, feel incredibly high, and can't hold my eyes open, at times. The blood pressure drops have happened, in the past, when I was not on Zanaflex, but this medication just seems to make it worse and I am not going to take it anymore. The side effects are too scary.”

6 / 10
Another surgery soon October 29, 2014

For Muscle Spasm: “I've been on various pain meds and muscle relaxants for years. Soma was working till these past 6 months. I have severe Spinal Stenosis, Degenerative Disc Disease, Arthritis, Fibromyalgia, Had Cervical Fusion in C5 & C in Jan 1st 2014, had Lumbar fusion in L5 & L4 about 5 years ago & now have Severe Herniated Disc's again at the L5 S1 region with nasty nerve pain radiating down Entire right leg to toes, along with Nasty Muscle Spasms & will be having another surgery soon. Been taking this for 3 days & doing great so far!”

9 / 10
Anonymous May 31, 2008

For Muscle Spasm: “Wonderful drug! Now available in Generic so doesn't cost an arm and a leg. I have severe disc and arthritic problems in my neck with severe muscle spasms and this really helps. At first when starting this medication it can cause a serious dopey feeling but this can be eased by gradually increasing the dose until benefits are produced. I am on 4mg 3 x a day and allowed to use 8 mg 3 x a day if my muscles are extremely spastic. Do not drive when taking this medication until you understand its effects.”

10 / 10
OodlesOPoodles · Taken for 1 to 6 months March 25, 2017

For Cluster Headaches: “Absolutely love this medication. I suffer from chronic migraines and daily headaches. I take 4mg of Zanaflex at breakfast, 2mg at lunch, and 4mg at bedtime. I'll take 6mg during a migraine attack and it helps tremendously with the pain, helps me sleep, and actually helps with the nausea. Zanaflex made me very drowsy at first and still does taken at doses of 4mg. Overall, incredibly helpful drug!”

9 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.