What is Miderizone used for?

Medically reviewed by Sally Chao, MD. Last updated on March 20, 2025.

Official Answer by Drugs.com

Miderizone (tolperisone) is a centrally acting muscle relaxant. It’s widely available in Europe and Asia and is marketed under different brand names, including:

Abbsa
Atmosgen
Arantoick
Besnoline
Isocalm
Kineorl
Menopatol
Metosomin
Minacalm
Mideton
Miodom
Muscalm
Musclex
Musocalm
Musolax
Myderison
Mydeton
Mydocalm
Naismeritin
Tolisartine
Tolson
Topxol
Tolfree
Userm

Miderizone is used to treat muscle spasticity due to muscular, vascular or neurological disorders. It comes as a 50 mg or 150 mg tablet that’s taken by mouth. Miderizone is usually taken with food.
The typical dosages are:

Adults: 50 mg to 150 mg, 3 times daily
Children:
- 5 years old and younger: 5 mg/kg daily in three divided doses
- 6 to 14 years of age: 2 to 4 mg/kg daily in three divided doses

Side effects of Miderizone are usually mild and may include:

Decreased urination
Sleepiness
Mood changes and confusion
Increased thirst
Decreased appetite
Nausea, vomiting, diarrhea or stomach cramps
Shortness of breath
Swelling
Weight gain
Skin rash
Dizziness
Rectal bleeding
Low potassium level

Tolperisone is not currently available in the United States. However, in 2017, Neurana Pharmaceuticals was granted approval to begin Phase 2 clinical studies of tolperisone in the United States.
Comparable centrally acting muscle relaxants currently available in the U.S. include:

References

Drugs.com. Miderizone 150 mg. 2022. Available at: https://www.drugs.com/international/miderizone-150-mg.html. [Accessed March 24, 2022].
Quasthoff S, Möckel C, Zieglgänsberger W, Schreibmayer W. Tolperisone. A typical representative of a class of centrally acting muscle relaxants with less sedative side effects. CNS Neurosci Ther. 2008;14(2):107-119. doi:10.1111/j.1527-3458.2008.00044.x. https://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2008.00044.x. [Accessed March 24, 2022].
Pill in trip. Medicine Search. Available at: https://pillintrip.com/advanced_search?components=3471. [Accessed March 24, 2022].
Ndrugs.com. Miderizone 150 mg uses. Available at: https://www.ndrugs.com/?s=miderizone%20150%20mg#generic. [Accessed March 24, 2022].
Practo.com. Tolperisone. 2017. Available at: https://www.practo.com/medicine-info/tolperisone-274-api. [Accessed March 24, 2022].
MIMS. Tolperisone. Available at: https://www.mims.com/hongkong/drug/info/tolperisone?mtype=generic. [Accessed March 24, 2022].
Cision PR Newswire. Neurana Pharmaceuticals Receives Notice of Allowance of Patents For Tolperisone, a Novel Skeletal Muscle Relaxant. May 25, 2017. Available at: https://www.prnewswire.com/news-releases/neurana-pharmaceuticals-receives-notice-of-allowance-of-patents-for-tolperisone-a-novel-skeletal-muscle-relaxant-300464196.html. [Accessed March 24, 2022].
Drugs.com. Skeletal muscle relaxants. March 20, 2018. Available at: https://www.drugs.com/drug-class/skeletal-muscle-relaxants.html. [Accessed March 24, 2022].
Drugs.com. Baclofen. September 1, 2021. Available at: https://www.drugs.com/baclofen.html. [Accessed March 28, 2022].
Drugs.com. Methocarbamol. April 14, 2020. Available at: https://www.drugs.com/methocarbamol.html. [Accessed March 28, 2022].
Drugs.com. Tizanidine. January 10, 2022. Available at: https://www.drugs.com/tizanidine.html. [Accessed March 28, 2022].

What is Miderizone used for?

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