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What is Miderizone used for?

Medically reviewed by Sally Chao, MD. Last updated on March 30, 2022.

Official answer

by Drugs.com

Miderizone (tolperisone) is a centrally acting muscle relaxant. It’s widely available in Europe and Asia and is marketed under different brand names, including:

  • Abbsa
  • Atmosgen
  • Arantoick
  • Besnoline
  • Isocalm
  • Kineorl
  • Menopatol
  • Metosomin
  • Minacalm
  • Mideton
  • Miodom
  • Muscalm
  • Musclex
  • Musocalm
  • Musolax
  • Myderison
  • Mydeton
  • Mydocalm
  • Naismeritin
  • Tolisartine
  • Tolson
  • Topxol
  • Tolfree
  • Userm

Miderizone is used to treat muscle spasticity due to muscular, vascular or neurological disorders. It comes as a 50 mg or 150 mg tablet that’s taken by mouth. Miderizone is usually taken with food.
The typical dosages are:

  • Adults: 50 mg to 150 mg, 3 times daily
  • Children:
    • 5 years old and younger: 5 mg/kg daily in three divided doses
    • 6 to 14 years of age: 2 to 4 mg/kg daily in three divided doses

Side effects of Miderizone are usually mild and may include:

  • Decreased urination
  • Sleepiness
  • Mood changes and confusion
  • Increased thirst
  • Decreased appetite
  • Nausea, vomiting, diarrhea or stomach cramps
  • Shortness of breath
  • Swelling
  • Weight gain
  • Skin rash
  • Dizziness
  • Rectal bleeding
  • Low potassium level

Tolperisone is not currently available in the United States. However, in 2017, Neurana Pharmaceuticals was granted approval to begin Phase 2 clinical studies of tolperisone in the United States.
Comparable centrally acting muscle relaxants currently available in the U.S. include:

References
  1. Drugs.com. Miderizone 150 mg. 2022. Available at: https://www.drugs.com/international/miderizone-150-mg.html. [Accessed March 24, 2022].
  2. Quasthoff S, Möckel C, Zieglgänsberger W, Schreibmayer W. Tolperisone. A typical representative of a class of centrally acting muscle relaxants with less sedative side effects. CNS Neurosci Ther. 2008;14(2):107-119. doi:10.1111/j.1527-3458.2008.00044.x. https://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2008.00044.x. [Accessed March 24, 2022].
  3. Pill in trip. Medicine Search. Available at: https://pillintrip.com/advanced_search?components=3471. [Accessed March 24, 2022].
  4. Ndrugs.com. Miderizone 150 mg uses. Available at: https://www.ndrugs.com/?s=miderizone%20150%20mg#generic. [Accessed March 24, 2022].
  5. Practo.com. Tolperisone. 2017. Available at: https://www.practo.com/medicine-info/tolperisone-274-api. [Accessed March 24, 2022].
  6. MIMS. Tolperisone. Available at: https://www.mims.com/hongkong/drug/info/tolperisone?mtype=generic. [Accessed March 24, 2022].
  7. Cision PR Newswire. Neurana Pharmaceuticals Receives Notice of Allowance of Patents For Tolperisone, a Novel Skeletal Muscle Relaxant. May 25, 2017. Available at: https://www.prnewswire.com/news-releases/neurana-pharmaceuticals-receives-notice-of-allowance-of-patents-for-tolperisone-a-novel-skeletal-muscle-relaxant-300464196.html. [Accessed March 24, 2022].
  8. Drugs.com. Skeletal muscle relaxants. March 20, 2018. Available at: https://www.drugs.com/drug-class/skeletal-muscle-relaxants.html. [Accessed March 24, 2022].
  9. Drugs.com. Baclofen. September 1, 2021. Available at: https://www.drugs.com/baclofen.html. [Accessed March 28, 2022].
  10. Drugs.com. Methocarbamol. April 14, 2020. Available at: https://www.drugs.com/methocarbamol.html. [Accessed March 28, 2022].
  11. Drugs.com. Tizanidine. January 10, 2022. Available at: https://www.drugs.com/tizanidine.html. [Accessed March 28, 2022].

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