Comparing Clonidine vs Methadone
| Clonidine | Methadone |
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| Clonidine | Methadone |
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Prescription only
Clonidine can be used to lower blood pressure and treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects. Clonidine should not be stopped suddenly... View more |
Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Related suggestions Opiate Withdrawal
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| More about Clonidine | More about Methadone | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Clonidine has an average rating of 7.2 out of 10 from a total of 761 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 21% reported a negative effect. |
Methadone has an average rating of 8.7 out of 10 from a total of 599 ratings on Drugs.com. 85% of reviewers reported a positive effect, while 5% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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See also: clonidine side effects in more detail. |
See also: methadone side effects in more detail. |
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| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all clonidine prices |
View all methadone prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | Methadone Diskets, Methadose, Methadose Sugar-Free | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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15 hours |
30 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 373 drugs are known to interact with clonidine:
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A total of 725 drugs are known to interact with methadone:
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| First Approval Date | |||||||||||||||||
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September 03, 1974 |
August 13, 1947 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.