Comparing Clonidine vs Methadone
| Clonidine | Methadone |
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| Clonidine | Methadone |
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Prescription only
Clonidine can be used to lower blood pressure and treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure lowering effects. Clonidine should not be stopped suddenly... View more |
Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Related suggestions Opiate Withdrawal
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| More about Clonidine | More about Methadone | ||||||||||||||||
| Generic Status | |||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Clonidine has an average rating of 7.1 out of 10 from a total of 728 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 22% reported a negative effect. |
Methadone has an average rating of 8.7 out of 10 from a total of 587 ratings on Drugs.com. 85% of reviewers reported a positive effect, while 5% reported a negative effect. |
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| Side Effects | |||||||||||||||||
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Commonly reported side effects include:
See also: clonidine side effects in more detail. |
See also: methadone side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all clonidine prices |
View all methadone prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR | Methadone Diskets, Methadose, Methadose Sugar-Free | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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15 hours |
30 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 365 drugs are known to interact with clonidine:
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A total of 691 drugs are known to interact with methadone:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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June 13, 2013 |
August 31, 2015 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.