Comparing Clonidine vs Guanfacine
| Clonidine | Guanfacine |
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| Clonidine | Guanfacine |
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Prescription only
Clonidine can be used to lower blood pressure and extended-release forms are used to treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects... View more |
Prescription only
Guanfacine is used to treat high blood pressure and the extended-release form (brand name Intuniv) is approved for the treatment of ADHD. Guanfacine can cause sedation, especially on therapy... View more |
Related suggestions High Blood Pressure (Hypertension)
ADHD (Attention Deficit Hyperactivity Disorder)
Tourette's Syndrome
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| More about Clonidine | More about Guanfacine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Clonidine has an average rating of 7.2 out of 10 from a total of 776 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
Guanfacine has an average rating of 6.1 out of 10 from a total of 318 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 32% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Clonidine side effects |
View all Guanfacine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Clonidine prices |
View all Guanfacine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | Intuniv | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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15 hours |
18 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 378 drugs are known to interact with Clonidine:
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A total of 489 drugs are known to interact with Guanfacine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 03, 1974 |
October 27, 1986 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.