Because no information is available on the use of guanfacine during breastfeeding and its possible negative effects on lactation, other agents may be preferred, especially while nursing a newborn or preterm infant.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Published information on the effects of guanfacine on serum prolactin or on lactation in nursing mothers was not found as of the revision date. Guanfacine decreases basal serum prolactin in men and nonnursing women. Serum prolactin continues to decrease for at least 7 years during continuous use.[1] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Hauger-Klevene JH, Balossi EC, Scornavacchi JC. Effects of guanfacine on growth hormone, prolactin, renin, lipoproteins and glucose in essential hypertension. Am J Cardiol. 1986;57:27E–31E. [PubMed: 3513527] [CrossRef]
Substance Identification
Substance Name
Guanfacine
CAS Registry Number
29110-47-2
Drug Class
Breast Feeding
Lactation
Milk, Human
Antihypertensive Agents
Adrenergic alpha-2 Receptor Agonists
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