Comparing Buprenorphine vs Methadone
Buprenorphine | Methadone |
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Buprenorphine | Methadone |
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Prescription only
Buprenorphine is a potent analgesic that should be only used to treat moderate to severe pain or for the treatment of opioid addiction under strict conditions. Different formulations of the drug... View more |
Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Related suggestions |
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More about Buprenorphine | More about Methadone | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Buprenorphine has an average rating of 6.7 out of 10 from a total of 1122 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 26% reported a negative effect. |
Methadone has an average rating of 8.7 out of 10 from a total of 599 ratings on Drugs.com. 85% of reviewers reported a positive effect, while 5% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: buprenorphine side effects in more detail. |
See also: methadone side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all buprenorphine prices |
View all methadone prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Belbuca, Brixadi, Buprenex, Butrans, Sublocade | Methadone Diskets, Methadose, Methadose Sugar-Free | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
48 hours |
30 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 692 drugs are known to interact with buprenorphine:
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A total of 725 drugs are known to interact with methadone:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
December 29, 1981 |
August 13, 1947 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.