Comparing Buprenorphine vs Methadone
| Buprenorphine | Methadone |
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| Buprenorphine | Methadone |
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Prescription only
Buprenorphine is a potent analgesic that should be only used to treat moderate to severe pain or for the treatment of opioid addiction under strict conditions. Different formulations of the drug... View more |
Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Related suggestions |
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| More about Buprenorphine | More about Methadone | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Buprenorphine has an average rating of 6.7 out of 10 from a total of 1149 ratings on Drugs.com. 57% of reviewers reported a positive effect, while 25% reported a negative effect. |
Methadone has an average rating of 8.7 out of 10 from a total of 606 ratings on Drugs.com. 84% of reviewers reported a positive effect, while 6% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Buprenorphine side effects |
View all Methadone side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Buprenorphine prices |
View all Methadone prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Belbuca, Brixadi, Buprenex, Butrans, Sublocade | Methadone Diskets, Methadose, Methadose Sugar-Free | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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48 hours |
30 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 717 drugs are known to interact with Buprenorphine:
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A total of 837 drugs are known to interact with Methadone:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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December 29, 1981 |
August 13, 1947 |
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| WADA Class View classifications | |||||||||||||||||
| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.