Methadone Drug Interactions
Currently displaying a list of 837 drugs known to interact with methadone.
- 420 major drug interactions
- 407 moderate drug interactions
- 10 minor drug interactions
Medications known to interact with methadone
Note: Showing generic names only.
5
A
- abacavir
- abametapir topical
- abarelix
- abiraterone
- acarbose
- acebutolol
- acetohexamide
- acetylcarbromal
- acrivastine
- adagrasib
- adalimumab
- adenosine
- albiglutide
- albuterol
- aldesleukin
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- almotriptan
- alogliptin
- alpelisib
- alprazolam
- alvimopan
- amifampridine
- amiloride
- aminoglutethimide
- amiodarone
- amisulpride
- amitriptyline
- amlodipine
- ammonium chloride
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- amyl nitrite
- anagrelide
- anakinra
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- arformoterol
- aripiprazole
- armodafinil
- arsenic trioxide
- asciminib
- ascorbic acid
- asenapine
- astemizole
- atazanavir
- atenolol
- atezolizumab
- atomoxetine
- atropine
- attapulgite
- avacopan
- avelumab
- azatadine
- azelastine nasal
- azilsartan medoxomil
- azithromycin
B
- baclofen
- baricitinib
- bedaquiline
- belladonna
- belzutifan
- benazepril
- bendroflumethiazide
- benzgalantamine
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betaxolol
- bexagliflozin
- bexarotene
- bicalutamide
- bimekizumab
- binimetinib
- biperiden
- bisacodyl
- bismuth subgallate
- bismuth subsalicylate
- bisoprolol
- bitolterol
- blinatumomab
- boceprevir
- bosentan
- bosutinib
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- cabozantinib
- canagliflozin
- canakinumab
- candesartan
- cannabidiol
- cannabis
- capivasertib
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- casanthranol
- cascara sagrada
- castor oil
- cemiplimab
- cenobamate
- ceritinib
- cetirizine
- cevimeline
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroquine
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chlorzoxazone
- cilostazol
- cimetidine
- ciprofloxacin
- cisapride
- citalopram
- clarithromycin
- clemastine
- clevidipine
- clidinium
- clobazam
- clofazimine
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clotrimazole
- clozapine
- cobicistat
- codeine
- conivaptan
- cosibelimab
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclosporine
- cyproheptadine
D
- dabrafenib
- danazol
- danicopan
- dantrolene
- dapagliflozin
- daridorexant
- darifenacin
- darunavir
- dasatinib
- daunorubicin
- daunorubicin liposomal
- deferasirox
- degarelix
- delavirdine
- deserpidine
- desflurane
- desipramine
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dicyclomine
- didanosine
- difelikefalin
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- dofetilide
- dolasetron
- donepezil
- dostarlimab
- doxazosin
- doxepin
- doxepin topical
- doxorubicin
- doxorubicin liposomal
- doxylamine
- dronabinol
- dronedarone
- droperidol
- dulaglutide
- duloxetine
- durvalumab
- duvelisib
E
- echinacea
- efavirenz
- elacestrant
- elafibranor
- elagolix
- eletriptan
- eliglustat
- elranatamab
- eluxadoline
- emapalumab
- empagliflozin
- enalapril
- enalaprilat
- encorafenib
- enflurane
- entacapone
- entrectinib
- enzalutamide
- epcoritamab
- epirubicin
- eplerenone
- eprosartan
- erdafitinib
- eribulin
- ertugliflozin
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- esomeprazole
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- etrasimod
- etravirine
- evening primrose
- exenatide
- ezogabine
F
- famotidine
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenoldopam
- fentanyl
- fexinidazole
- fingolimod
- flavoxate
- flecainide
- flibanserin
- fluconazole
- fluoxetine
- fluphenazine
- flurazepam
- flutamide
- fluvoxamine
- formoterol
- fosamprenavir
- fosaprepitant
- foscarnet
- fosinopril
- fosphenytoin
- fospropofol
- fostamatinib
- fostemsavir
- frovatriptan
- furazolidone
- furosemide
- futibatinib
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- gatifloxacin
- gemfibrozil
- gemifloxacin
- gepirone
- gilteritinib
- ginkgo
- givinostat
- givosiran
- glasdegib
- glimepiride
- glipizide
- glofitamab
- glyburide
- glycerin
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- golimumab
- goserelin
- granisetron
- grepafloxacin
- griseofulvin
- guanabenz
- guanadrel
- guanethidine
- guanfacine
- guselkumab
H
- halazepam
- halofantrine
- haloperidol
- halothane
- heroin
- histrelin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
I
- ibrutinib
- ibutilide
- idarubicin
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- indacaterol
- indapamide
- indinavir
- indocyanine green
- infliximab
- inotuzumab ozogamicin
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- iohexol
- iomeprol
- iopamidol
- ipilimumab
- iptacopan
- irbesartan
- isavuconazonium
- isocarboxazid
- isoetharine
- isoflurane
- isoniazid
- isoproterenol
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- istradefylline
- itraconazole
- ivabradine
- ivacaftor
- ivosidenib
K
L
- labetalol
- lactitol
- lactulose
- lamotrigine
- landiolol
- lansoprazole
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- lenvatinib
- lesinurad
- letermovir
- leuprolide
- levalbuterol
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- linagliptin
- lindane topical
- linezolid
- liraglutide
- lisdexamfetamine
- lisinopril
- lithium
- lixisenatide
- lofexidine
- lomefloxacin
- lomitapide
- lonafarnib
- lonapegsomatropin
- loperamide
- lorazepam
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
M
- macimorelin
- magnesium citrate
- magnesium hydroxide
- maprotiline
- mavacamten
- mavorixafor
- mazindol
- mebrofenin
- meclizine
- mefloquine
- melatonin
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaproterenol
- metaxalone
- metformin
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methoxyflurane
- methscopolamine
- methsuximide
- methyclothiazide
- methyldopa
- methylene blue
- metoclopramide
- metolazone
- metoprolol
- metreleptin
- metrizamide
- metronidazole
- metyrosine
- mibefradil
- miconazole
- midazolam
- midostaurin
- mifepristone
- miglitol
- milnacipran
- mineral oil
- minoxidil
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- moexipril
- molindone
- morphine
- morphine liposomal
- mosunetuzumab
- moxifloxacin
N
- nabilone
- nadolol
- nafcillin
- nalbuphine
- naloxone
- naltrexone
- naratriptan
- nateglinide
- nebivolol
- nefazodone
- nelfinavir
- nemolizumab
- neratinib
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nilutamide
- nimodipine
- nirogacestat
- nisoldipine
- nitisinone
- nitroglycerin
- nitroprusside
- nitrous oxide
- nivolumab
- norfloxacin
- nortriptyline
O
- ofloxacin
- olanzapine
- olaparib
- oliceridine
- olmesartan
- olodaterol
- olopatadine nasal
- olutasidenib
- omaveloxolone
- omeprazole
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- osimertinib
- oxaliplatin
- oxandrolone
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- oxytocin
- ozanimod
P
- pacritinib
- palbociclib
- paliperidone
- palonosetron
- panobinostat
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- pasireotide
- pazopanib
- peginterferon alfa-2a
- peginterferon alfa-2b
- pegvisomant
- pembrolizumab
- penbutolol
- pentamidine
- pentazocine
- pentobarbital
- perampanel
- perflutren
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenolphthalein
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenylbutazone
- phenytoin
- pimavanserin
- pimozide
- pindolol
- pioglitazone
- pirbuterol
- pirtobrutinib
- pitolisant
- polyethylene glycol 3350
- polyethylene glycol 3350 with electrolytes
- polythiazide
- ponatinib
- ponesimod
- posaconazole
- potassium acid phosphate
- pralsetinib
- pramipexole
- pramlintide
- prasugrel
- prazosin
- pregabalin
- pretomanid
- primaquine
- primidone
- probucol
- procainamide
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propantheline
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- ramelteon
- ramipril
- ranolazine
- rasagiline
- rauwolfia serpentina
- relugolix
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- repotrectinib
- reserpine
- retifanlimab
- revumenib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- rilpivirine
- risperidone
- ritlecitinib
- ritodrine
- ritonavir
- rivastigmine
- rizatriptan
- rolapitant
- romidepsin
- ropeginterferon alfa-2b
- ropinirole
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- salmeterol
- saquinavir
- sarecycline
- sarilumab
- satralizumab
- saxagliptin
- scopolamine
- secobarbital
- secukinumab
- selegiline
- selpercatinib
- semaglutide
- senna
- sertraline
- sevoflurane
- sibutramine
- sildenafil
- silodosin
- siltuximab
- siponimod
- sirolimus
- sitagliptin
- sodium oxybate
- sodium polystyrene sulfonate
- sofpironium topical
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sorafenib
- sotagliflozin
- sotalol
- sotorasib
- sparfloxacin
- sparsentan
- spironolactone
- st. john's wort
- stavudine
- stiripentol
- sufentanil
- sulfamethoxazole
- sulfinpyrazone
- sumatriptan
- sunitinib
- suvorexant
- suzetrigine
T
- tacrine
- tacrolimus
- talquetamab
- tamoxifen
- tamsulosin
- tapentadol
- tarlatamab
- tasimelteon
- tazemetostat
- tebentafusp
- teclistamab
- tecovirimat
- tedizolid
- telaprevir
- telavancin
- telithromycin
- telmisartan
- telotristat
- temazepam
- temsirolimus
- tepotinib
- terazosin
- terbinafine
- terbutaline
- terfenadine
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiotepa
- thiothixene
- tiagabine
- ticagrelor
- timolol
- timolol ophthalmic
- tirzepatide
- tislelizumab
- tizanidine
- tocilizumab
- tofacitinib
- tolazamide
- tolbutamide
- tolcapone
- tolterodine
- tolvaptan
- topiramate
- toremifene
- toripalimab
- torsemide
- tovorafenib
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- tremelimumab
- treosulfan
- triamterene
- triazolam
- trichlormethiazide
- triclabendazole
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- triptorelin
- trofinetide
- troglitazone
- troleandomycin
- trospium
- tryptophan
- tucatinib
U
V
- vadadustat
- valbenazine
- valerian
- valproic acid
- valsartan
- vandetanib
- vardenafil
- vasopressin
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- vimseltinib
- voclosporin
- vonoprazan
- vorasidenib
- voriconazole
- vortioxetine
- voxelotor
Z
Methadone alcohol/food interactions
There is 1 alcohol/food interaction with methadone.
Methadone disease interactions
There are 16 disease interactions with methadone which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
Report options
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- Drug class: Opioids (narcotic analgesics)
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
