Methadone Drug Interactions

Currently displaying a list of 836 drugs known to interact with methadone.

Return to the list of commonly checked interactions in combination with this medicine.

Medications known to interact with methadone

Note: Showing generic names only.

Include all brand names and combination drug names.

There are 16 disease interactions with methadone which include:

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These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.