Lucemyra Dosage
Generic name: LOFEXIDINE HYDROCHLORIDE 0.2mg
Dosage form: tablet, film coated
Drug class: Antiadrenergic agents, centrally acting
Medically reviewed by Drugs.com. Last updated on Sep 19, 2024.
Dosing Information
The usual LUCEMYRA starting dosage is three 0.18 mg tablets taken orally 4 times daily during the period of peak withdrawal symptoms (generally the first 5 to 7 days following last use of opioid) with dosing guided by symptoms and side effects. There should be 5 to 6 hours between each dose. The total daily dosage of LUCEMYRA should not exceed 2.88 mg (16 tablets) and no single dose should exceed 0.72 mg (4 tablets).
LUCEMYRA treatment may be continued for up to 14 days with dosing guided by symptoms.
Discontinue LUCEMYRA with a gradual dose reduction over a 2- to 4-day period to mitigate LUCEMYRA withdrawal symptoms (e.g., reducing by 1 tablet per dose every 1 to 2 days). The LUCEMYRA dose should be reduced, held, or discontinued for individuals who demonstrate a greater sensitivity to LUCEMYRA side effects. Lower doses may be appropriate as opioid withdrawal symptoms wane.
LUCEMYRA can be administered in the presence or absence of food.
Dosage Recommendations for Patients with Hepatic Impairment
Recommended dosage adjustments based on the degree of hepatic impairment are shown in Table 1..
Mild Impairment | Moderate Impairment | Severe Impairment | |
---|---|---|---|
Child-Pugh score | 5-6 | 7-9 | > 9 |
Recommended dose | 3 tablets 4 times daily (2.16 mg per day) |
2 tablets 4 times daily (1.44 mg per day) |
1 tablet 4 times daily (0.72 mg per day) |
Dosage Recommendations for Patients with Renal Impairment
Recommended dosage adjustments based on the degree of renal impairment are shown in Table 2. LUCEMYRA may be administered without regard to the timing of dialysis.
Moderate Impairment | Severe Impairment, End-Stage Renal Disease, or on Dialysis | |
---|---|---|
Estimated GFR, mL/min/1.73 m2 | 30-89.9 | < 30 |
Recommended dose | 2 tablets 4 times daily (1.44 mg per day) |
1 tablet 4 times daily (0.72 mg per day) |
Frequently asked questions
- How does Lucemyra make you feel?
- Is Lucemyra (lofexidine) a controlled drug?
- How do you get Lucemyra (lofexidine)?
- How does Lucemyra work in the treatment of opioid withdrawal?
- How long does lofexidine typically take to work?
More about Lucemyra (lofexidine)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (45)
- Drug images
- Side effects
- Patient tips
- During pregnancy
- Generic availability
- FDA approval history
- Drug class: antiadrenergic agents, centrally acting
- Breastfeeding
- En español
Patient resources
Professional resources
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.