Skip to main content

How does Lucemyra make you feel?

Medically reviewed by Sally Chao, MD. Last updated on May 2, 2024.

Official answer


Lucemyra (lofexidine) may make you feel the symptoms of acute opioid withdrawal less intensely, but it will not block them altogether. It reduces your withdrawal discomfort, but while taking Lucemyra, you may still feel some aches, pains and headaches, and may experience poor or disrupted sleep.

On top of the opioid withdrawal symptoms that may persist while taking Lucemyra, the drug may also cause side effects. Some potential side effects reported in studies include:

  • Trouble sleeping
  • Low blood pressure
  • Slow heart rate
  • Dizziness
  • Dry mouth
  • Sleepiness or feeling sedated

Other less common side effects include feeling faint or fainting, ringing in the ears and dry mouth.

Low blood pressure and slow heart rate are potentially severe side effects of Lucemyra. Patients should pay attention to signs of these problems, like dizziness, feeling lightheaded, and feeling faint while resting or when abruptly standing up. Staying hydrated and standing up slowly and carefully can lower the risks of fainting or complications related to low blood pressure.

Untreated opioid withdrawal may be life-threatening and can lead to many symptoms, such as:

  • Nausea
  • Vomiting
  • Diarrhea
  • Sweating
  • Watery eyes
  • Dilated pupils
  • Goosebumps on the skin
  • Stomach cramps
  • Pain
  • Anxiety/restlessness
  • Trouble sleeping
  • Hot or cold flashes
  • Muscle spasms and pain
  • Pounding heartbeat

Lucemyra can help mitigate these symptoms. However, it may not suppress all symptoms of opioid withdrawal equally.

Lucemyra may be taken for up to 14 days with dosing changes as needed, as the intense symptoms of opioid withdrawal will typically have dissipated by this point.

  1. U.S. Food and Drug Administration (FDA). LUCEMYRA™ (lofexidine) tablets. 2018. Available at: [Accessed April 15, 2021].
  2. Fishman M, Tirado C, Alam D, et al. Safety and Efficacy of Lofexidine for Medically Managed Opioid Withdrawal: A Randomized Controlled Clinical Trial. J Addict Med. 2019;13(3):169-176. doi:10.1097/ADM.0000000000000474
  3. Pergolizzi Jr. JV, Annabi H, Gharibo C, LeQuang JA. The Role of Lofexidine in Management of Opioid Withdrawal. Pain Ther. 2019;8(1):67-78. doi:10.1007/s40122-018-0108-7

Read next

Related medical questions

Drug information

Related support groups