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How is Sublocade administered?

Medically reviewed by Last updated on Jan 12, 2021.

Official Answer


Sublocade is given by a health care provider, once monthly by subcutaneous injection in the abdominal (stomach) region. Use only the syringe and safety needle included in the packaging.

Sublocade (buprenorphine), from Indivior, is an extended-release, once-monthly injection for opioid use disorder (OUD). It is used in adult patients already on a stable dose of transmucosal (absorbed via mucus membrane) buprenorphine for a minimum of 7 days. Sublocade may reduce the burden of taking daily medication for patients in recovery.

What is the dose of Sublocade?

Sublocade is available in a prefilled syringe as a 100 mg per 0.5 mL or 300 mg per 1.5 mL strength of buprenorphine. The recommended dose of Sublocade following stabilization with transmucosal buprenorphine is 300 mg monthly for the first two months followed by a maintenance dose of 100 mg monthly. The provider may choose to increase the maintenance dose to 300 mg monthly for patients who tolerate the 100 mg dose, but do not have an acceptable clinical response, as shown by self-reported use of illicit opioids or positive opioid urine drug screens.

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